Multipl Skleroz Hastalığının Engellilik Seviyesine Göre Maliyetleri: Sistematik Derleme Çalışması

Yıl 2021, Cilt: 30 Sayı: 2, 101 - 118, 30.06.2021

Selin Kalender Vahit Yiğit

https://doi.org/10.17827/aktd.876840

Öz

Amaç: Bu çalışma MS hastalarının engellilik seviyeleri ile hastalığın toplam maliyetleri arasındaki ilişkinin ortaya konulmasını amaçlamaktadır. Gereç ve Yöntem: Bu amaçla literatürde hastaların EDSS (Expanded Disability Status Scale) ile belirlenen engellilik seviyelerine göre toplam maliyetlerinin değerlendirildiği hastalık maliyeti (Cost of Illness) çalışmalarının sistematik derlemesi yapılmıştır. Çalışma kapsamında literatür taraması PubMed veri tabanı üzerinde gerçekleştirilmiştir. Çalışmaya Ocak 2000-Aralık 2019 yılları arasında İngilizce olarak yayınlanan, hasta bireyler üzerinde gerçekleştirilen ve doğrudan-dolaylı maliyetlerin hesaplandığı araştırma makaleleri dahil edilmiştir. Tarama 825 yayın ile sonuçlanmıştır. Belirlenen dahil etme kriterleri çerçevesinde maliyetlerin hastaların engellilik seviyelerine göre hesaplandığı 52 çalışma değerlendirme kapsamına alınmış ve sonuçları analiz edilerek karşılaştırılmıştır. Bulgular: Hastalığın toplam maliyetleri (doğrudan+dolaylı) hastaların engellilik seviyelerinin artması ile birlikte (hafif seviye engellilik 26.925 $; orta seviye engellilik 44.429 $; şiddetli seviye engellilik 66.792 $) yükselmektedir. Doğrudan maliyetler içerisinde ilaç tedavi (DMT’ler ve diğer ilaçlar) maliyetleri (%4-%90), dolaylı maliyetler içerisinde ise üretim kayıpları (%3-%68) ana maliyet bileşenini oluşturmaktadır. Sonuç: Çalışmalar arasındaki çeşitli metodolojik farklılıklara rağmen elde edilen sonuçlar, MS’in yükselen maliyetleri nedeniyle önemli ve öncelikli olarak ele alınması gereken bir sağlık sorunu olduğunu ortaya koymaktadır.

Anahtar Kelimeler

Multipl skleroz, hastalık maliyeti, sistematik derleme

Costs of Multiple Sclerosis According to the Level of Disability: A Systematic Review Study

Öz

This study aims to reveal the relationship between the disability levels of MS patients and the total costs of the disease.
For this purpose, a systematic review of Cost of Illness studies on MS in the literature, in which the total costs of
patients are evaluated according to their disability levels determined the EDSS (Expanded Disability Status Scale), has
been performed. Within the scope of the study, the literature search was carried out on the PubMed database. The
study included research articles published in English between January 2000 and December 2019, performed on
sick individuals and calculating direct and indirect costs. The search resulted in 825 publications. 52 studies in which
costs were calculated according to the disability levels of the patients within the framework of the inclusion criteria
were included in the evaluation and their results were analyzed and compared. The total annual costs of the disease
(direct + indirect) increase with the increase in the disability level of the patients (mild disability $ 26,925; moderate
disability $ 44,429; severe disability $ 66,792). Among the direct costs, drugs (Disease modifying drugs and others)
costs (4-90%) and within indirect costs, production losses (3-68%) are the main cost components. Despite the various
methodological differences between the studies, the results obtained reveal that MS is an important and priority
health problem due to its rising costs.

Anahtar Kelimeler

Multiple sclerosis, cost of illness, systematic review

Kaynakça

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