Prevention of Oxidative Stress in Ovarian Torsion Detorsion: Data from Experimental Studies

Yıl 2024, Cilt: 33 Sayı: 4, 262 - 266, 31.12.2024

Yurdun Kuyucu , Samet Kara , Kezban Kartlaşmış , Ayşe Nur Çakır Güngör

https://doi.org/10.17827/aktd.1604053

Öz

Ovarian torsion is twisting of the ovary around the ligaments that support it. It is a rare, but an important gynecological emergency. Detorsion of the ovary surgically is preferred in patients to preserve the fertility. Ovarian detorsion causes tissue damage in response to excessive reactive oxygen species and accumulation of the activated neutrophils. In this review, antioxidant and anti-inflammatory agents that have been investigated in the literature to prevent the ovarian injury due to oxidative stress are summarised.

Anahtar Kelimeler

Ovary, torsion detorsion, oxidative stress

Over Torsiyon Detorsiyonunda Oksidatif Stresin Önlenmesi: Deneysel Çalışmalardan Elde Edilen Veriler

Öz

Over torsiyonu, overin kendisini destekleyen ligamentler etrafında dönmesidir. Nadir görülen ancak önemli bir jinekolojik acil durumdur. Doğurganlığı korumak için hastalarda overin cerrahi olarak detorsiyonu tercih edilir. Over detorsiyonu, aşırı reaktif oksijen türlerinin ve aktif nötrofillerin birikimine yanıt olarak doku hasarına neden olur. Bu derlemede, oksidatif strese bağlı over hasarını önlemek için literatürde araştırılan antioksidan ve antienflamatuvar ajanlar özetlenmiştir.

Anahtar Kelimeler

Over, torsiyon detorsiyon, oksidatif stres

Kaynakça

• 1. Huang C, Hong MK, Ding DC. A review of ovary torsion. Tzu Chi Medical Journal 2017; 29(3): 143-147.
• 2. Dasgupta R, Renaud E, Goldin AB, et al. Ovarian torsion in pediatric and adolescent patients: A systematic review. Journal of Pediatric Surgery 2018; 53: 1387–1391.
• 3. Tielli A, Scala A, Alison M, et al. Ovarian torsion: diagnosis, surgery, and fertility preservation in the pediatric population. European Journal of Pediatrics 2022; 181:1405–1411.
• 4. Demir Çaltekin M, Özkut MM, Çaltekin İ, et al. The protective effect of JZL184 on ovarian ischemia reperfusion injury and ovarian reserve in rats. J Obstet Gynaecol Res 2021; 47(8): 2692-2704.
• 5. Kara M, Daglioglu YK, Kuyucu Y, Tuli A, Tap O. The effect of edaravone on ischemia–reperfusion injury in rat ovary. European Journal of Obstetrics & Gynecology and Reproductive Biology 2012; 162: 197–202.
• 6. Gencer M, Karaca T, Güngör AN, et al. The protective effect of quercetin on IMA levels and apoptosis in experimental ovarian ischemia-reperfusion injury. Eur J Obstet Gynecol Reprod Biol 2014: 177: 135-40.
• 7. Chang-Patel EJ, Palacios-Helgeson LK, Gould CH. Adnexal torsion: a review of diagnosis and management strategies. Curr Opin Obstet Gynecol 2022; 34(4): 196-203.
• 8. A Kazez, SK Ozel, N Akpolat, M Goksu. The efficacy of conservative treatment for late term ovarian torsion. Eur J Pediatr Surg 2007; 17(2):110-4.
• 9. Bayir Y, Karagoz Y, Karakus E, et al. Nigella Sativa reduces tissue damage in rat ovaries subjected to torsion and detorsion: oxidative stress, proinflammatory response and histopathological evaluation. Gynecol Obstet Invest 2012; 74(1): 41-9.
• 10. Trocha M, Merwid-Ląd A, Pieśniewska M, et al. Age-related differences in function and structure of rat livers subjected to ischemia/reperfusion. Arch Med Sci 2018; 14 (2): 388–395.
• 11. Prillaman HM, Turner TT. Rescue of testicular function after acute experimental torsion. J Urol 1997;157 (1): 340-5.
• 12. Laganà AS, Sofo V, Salmeri FM, et al. Oxidative stress during ovarian torsion in pediatric and adolescent patients: changing the perspective of the disease. Int J Fertil Steril 2016; 9(4): 416-23.
• 13. Trocha M, Merwid-Ląd A, Chlebda E, et al. Influence of ezetimibe on selected parameters of oxidative stress in rat liver subjected to ischemia/reperfusion. Arch Med Sci 2014;10 (4): 817-24.
• 14. Quercetin protects against lipopolysaccharide-induced acute lung injury in rats through suppression of inflammation and oxidative stress. Arch Med Sci 2015; 11 (2): 427-32.
• 15. Barghi B, Shokoohi M, Khaki AA, Khaki A, Moghimian M, Soltani M. Eugenol improves tissue damage and oxidative stress in adult female rats after ovarian torsion/detorsion. J Obstet Gynaecol 2021; 41(6): 933-938.
• 16. Turkler C, Kiremitli T, Onat T, et al. Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries? Arch Med Sci 2019; 18 (5): 1364-1371.
• 17. Gungor AN, Turkon H, Albayrak A, et al. Does Omegaven have beneficial effects on a rat model of ovarian ischemia/reperfusion? Eur J Obstet Gynecol Reprod Biol 2014; 181:240-5.
• 18. Hascalik S, Celik O, Turkoz Y, Hascalik M, Cigremis Y, Mizrak B. Resveratrol, a red wine constituent polyphenol, protects from ischemia–reperfusion damage of the ovaries. Gynecol Obstet Invest 2004; 57(4): 218–23.
• 19. Oral A, Odabasoglu F, Halici Z, et al.Protective effects of montelukast on ischemia-reperfusion injury in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. Fertil Steril 2011; 95(4): 1360-6.
• 20. Usta U, Inan M, Erbas H, Aydogdu N, Oz Puyan F, Altaner S. Tissue damage in rat ovaries subjected to torsion and detorsion: effects of L-carnitine and N-acetyl cysteine. Pediatr Surg Int 2008; 24(5): 567-73.
• 21. Cadirci E, Oral A, Odabasoglu F, et al. Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. Naunyn Schmiedebergs Arch Pharmacol 2010; 381(5): 455-66.
• 22. Akdemir A, Erbas O, Gode F, et al. Protective effect of oxytocin on ovarian ischemia-reperfusion injury in rats. Peptides 2014; 55: 126-30.
• 23. Sakin O, Anğın AD, Akalın EE, Cikman MS, Basak K, Kaptanagasi AO. Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary. Ginekol Pol 2019; 90(9): 513-519.
• 24. Bostancı MS, Budak Ö, Çakiroğlu H, Gök K, Köse O, Çokluk E. The effect of protection of platelet-rich plasma against experimental ischemia/reperfusion injury in the rat ovary on in vitro fertilization outcomes. J Obstet Gynaecol Res 2022; 48(6): 1390-1398.
• 25. Güler MC, Tanyeli A, Erdoğan DG, et al. Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation. Iran J Basic Med Sci 2021; 24(7): 935-942.
• 26. Dayangan Sayan C, Karaca G, Sema Ozkan Z, et al. What is the protective effect of metformin on rat ovary against ischemia-reperfusion injury? J Obstet Gynaecol Res 2018; 44(2): 278-285.
• 27. Türk E, Karaca İ, Ozcinar E, et al. The effect of hypothermia on adnexal torsion/detorsion injury in a rat ovary model. J Pediatr Surg 2015; 50(8): 1378-81.
• 28. Eken MK, Ersoy GS, Kaygusuz EI, et al. Etanercept protects ovarian reserve against ischemia/reperfusion injury in a rat model. Arch Med Sci 2019; 15(4): 1104-1112.
• 29. Celik E, Oguzturk H, Sahin N, Turtay MG, Oguz F, Ciftci O. Protective effects of hesperidin in experimental testicular ischemia/reperfusion injury in rats. Arch Med Sci 2016; 12(5): 928-934.
• 30. Cakir Gungor AN, Gencer M, Karaca T, et al. The effect of hesperetin on ischemia-reperfusion injury in rat ovary. Arch Gynecol Obstet 2014; 290 (4): 763-9.
• 31. Süzen Çaypınar S, Karakaş S, Kaya C, Sakız D, Sezer S, Ekin M. The effect of medical ozone therapy in addition to ovarian detorsion in ischemia reperfusion model. J Obstet Gynaecol 2022; 42(7): 3164-3171.