The Schizophrenia hypothesis: Tyrosine hydroxylase pathway

Yıl 2025, Cilt: 34 Sayı: 1, 25 - 30, 31.03.2025

Osman Ozdemir

https://doi.org/10.17827/aktd.1574857

Öz

It has been previously reported that there was no significant difference in tyrosine hydroxylase activity between schizophrenia patients and controls. In that case, where does an excessive dopamine come from in the patients with psychosis. It should be come back here and this hypothesis must be rehandle and reconsider over and over. On the other hand, as expected, high tyrosine hydroxylase activity showed in basal ganglia, putamen, caudate nucleus and nucleus accumbens, in patient with schizophrenia compared to controls.

Anahtar Kelimeler

Tyrosine hydroxylase pathway, dopamine, phosphorylation, schizophrenia, hypothesis

Şizofreni hipotezi: Tirozin hidroksilaz yolağı

Öz

Daha önce şizofreni hastaları ve kontroller arasında tirozin hidroksilaz aktivitesinde önemli bir fark olmadığı bildirilmişti. O zaman psikoz hastalarında aşırı dopamin nereden geliyor? Buraya geri dönülmeli ve bu hipotez tekrar tekrar ele alınmalı ve yeniden düşünülmelidir. Öte yandan, beklendiği gibi, şizofreni hastalarında kontrollerle karşılaştırıldığında bazal ganglionlarda, putamende, kaudat çekirdekte ve çekirdek akumbenste yüksek tirozin hidroksilaz aktivitesi gösterildi.

Anahtar Kelimeler

Tirozin hidroksilaz yolağı, dopamin, fosforilasyon, şizofreni, hipotez

Kaynakça

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