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TARE Tedavilerinde CBCT ve SPECT/CT Doz Uygulama Korelasyonu

Yıl 2025, Cilt: 34 Sayı: 1, 61 - 67, 31.03.2025
https://doi.org/10.17827/aktd.1604220

Öz

AMAÇ: Çalışmamızda Tare tedavilerinde Cone Beam Computed Tomography (CBCT)’nin ve Tek Foton Emisyonlu Bilgisayarlı Tomografi/X-Işını Bilgisayarlı Tomografi (SPECT/CT) doz uygulama korelasyonunun incelenmesi amaçlanmıştır.
GEREÇ-YÖNTEM: Transarterial radyoembolizasyon (TARE) tedavilerinde kullanılan mikroalbümin agregat (MAA) ile etkinliğini incelemek için kullanılan yaygın yöntemlerden CBCT ve SPECT/CT’nin özellikleri ve kullanım avantajları yönünden incelenmiştir. CBCT ve SPECT/CT’nin doz uygulamaları arasında yapılan literatür çalışmaları ışığında değerlendirilmiştir.
SONUÇ: Son yıllarda gelişen teknoloji ile ileri seviye uygulamalar ile hastalarda maksimum etki minimum yan etki olacak şekilde planlamalar yapılarak fayda sağladığı söylenebilir. Çalışmalarda son yıllarda CBCT ve SPECT/CT arasında korelasyon bulunduğu birlikte planlandığında verim oranının arttığı görülmüştür. TARE tedavilerinde CBCT önemli bir tedavi destekleyici sistem olup tedavinin etkin ve güvenilir bir şekilde yapılmasına yardımcı olmaktadır. Ayrıca ikili planlanlama stratejilerinin yapay zeka destekli çalışmalar ile desteklenmesi tedavi şeklinde oluşabilecek endikasyonları minimize edeceği düşünülmektedir.

Etik Beyan

Bu çalışma, halka açık olan ve üniversite kütüphanesinden erişilebilen yayınlardan yararlanılarak hazırlanmıştır.

Kaynakça

  • 1. Kobe A, Zgraggen J, Messmer F, Puippe G, Sartoretti T, Alkadhi H, et al. Prediction of treatment response to transarterial radioembolization of liver metastases: Radiomics analysis of pre-treatment cone-beam CT: A proof of concept study. Eur J Radiol Open. 2021;8:100375.
  • 2. Rodríguez-Fraile M, Ezponda A, Grisanti F, Morán V, Calvo M, Berián P, et al. The joint use of 99m Tc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning. EJNMMI Res. 2021;11:1-11.
  • 3. Ertreo M, Choi H, Field D, Lischalk JW, Cohen E, Lynskey GE, et al. Comparison of cone-beam tomography and cross-sectional imaging for volumetric and dosimetric calculations in resin yttrium-90 radioembolization. Cardiovasc Intervent Radiol. 2018;41:1857-1866.
  • 4. O’Connor PJ, Pasik SD, van der Bom IM, Bishay V, Radaelli A, Kim E. Feasibility of yttrium-90 radioembolization dose calculation utilizing intra-procedural open trajectory cone beam CT. Cardiovasc Intervent Radiol. 2020;43:295-301.
  • 5. Zhang Y, Tehrani JN, Wang J. A biomechanical modeling guided CBCT estimation technique. IEEE Trans Med Imaging. 2016;36(2):641-652.
  • 6. Lau WY, Kennedy AS, Kim YH, Lai HK, Lee RC, Leung TW, et al. Patient selection and activity planning guide for selective internal radiotherapy with yttrium-90 resin microspheres. Int J Radiat Oncol Biol Phys. 2012;82(1):401-407.
  • 7. Gandhi SJ, Babu S, Subramanyam P, Sundaram PS. Tc-99m macro aggregated albumin scintigraphy–Indications other than pulmonary embolism: A pictorial essay. Indian J Nucl Med. 2013;28(3):152-162.
  • 8. Fukuoka M, Kobayashi T, Satoh T, Tanaka A, Akiko K. Studies of quality control of 99mTc-labelled macroaggregated albumin—Part 1. Aggregation of non-mercaptalbumin and its conformation. Nucl Med Biol. 1993;20(5):643-648.
  • 9. Villalobos A, Cheng B, Wagstaff W, Sethi I, Bercu Z, Schuster DM, et al. Tumor-to-normal ratio relationship between planning Technetium-99 macroaggregated albumin and posttherapy Yttrium-90 Bremsstrahlung SPECT/CT. J Vasc Interv Radiol. 2021;32(5):752-760.
  • 10. Canziani L, Marenco M, Cavenaghi G, Manfrinato G, Taglietti A, Girella A, et al. Chemical and Physical Characterisation of Macroaggregated Human Serum Albumin: Strength and Specificity of Bonds with 99mTc and 68Ga. Molecules. 2022;27(2):404.
  • 11. Chen G, Lu Z, Jiang H, Lin KH, Mok GS. Voxel-S-value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT. Sci Rep. 2023;13(1):4020.
  • 12. Tabotta F, Gnesin S, Dunet V, Ponti A, Digklia A, Boughdad S, et al. 99mTc-macroaggregated albumin SPECT/CT predictive dosimetry and dose-response relationship in uveal melanoma liver metastases treated with first-line selective internal radiation therapy. Sci Rep. 2023;13(1):13118.
  • 13. Doyle PW, Workman CS, Grice JV, McGonigle TW, Huang S, Borgmann AJ, et al. Predictive Dosimetry and Outcomes of Hepatocellular Carcinoma Treated by Yttrium-90 Resin Microsphere Radioembolization: A Retrospective Analysis Using Technetium-99m Macroaggregated Albumin SPECT/CT and Planning Software. J Vasc Interv Radiol. 2024;35(5):689-698.
  • 14. Kumar M, Shanavas M, Sidappa A, Kiran M. Cone beam computed tomography-know its secrets. J Int Oral Health. 2015;7(2):64.
  • 15. Walter C, Schmidt JC, Rinne CA, Mendes S, Dula K, Sculean A. Cone beam computed tomography (CBCT) for diagnosis and treatment planning in periodontology: systematic review update. Clin Oral Investig. 2020;24:2943-2958.
  • 16. Fiore F, Somma F, D’Angelo R, Tarotto L, Stoia V. Cone beam computed tomography (CBCT) guidance is helpful in reducing dose exposure to pediatric patients undergoing radiofrequency ablation of osteoid osteoma. Radiol Med. 2022;127(2):183-190.
  • 17. Alshomrani F. Cone-Beam Computed Tomography (CBCT)-Based Diagnosis of Dental Bone Defects. Diagnostics. 2024;14(13):1404.
  • 18. Rashid A, Feinberg L, Fan K. The Application of Cone Beam Computed Tomography (CBCT) on the Diagnosis and Management of Maxillofacial Trauma. Diagnostics. 2024;14(4):373.
  • 19. Ritt P. Recent developments in SPECT/CT. Semin Nucl Med. 2022;52(3):276-285.
  • 20. Dietze MM, Kunnen B, Van Der Velden S, Steenbergen JL, Koppert WJ, Viergever MA, et al. Performance of a dual-layer scanner for hybrid SPECT/CBCT. Phys Med Biol. 2019;64(10):105020.
  • 21. Römer W, Reichel N, Vija HA, Nickel I, Hornegger J, Bautz W, et al. Isotropic reconstruction of SPECT data using OSEM3D: correlation with CT. Acad Radiol. 2006;13(4):496-502.
  • 22. Geworski L, Knoop BO, de Cabrejas ML, Knapp WH, Munz DL. Recovery correction for quantitation in emission tomography: a feasibility study. Eur J Nucl Med. 2000;27:161-169.
  • 23. Malina-Altzinger J, Klaeser B, Suter VG, Schriber M, Vollnberg B, Schaller B. Comparative evaluation of SPECT/CT and CBCT in patients with mandibular osteomyelitis and osteonecrosis. Clin Oral Investig. 2019;23:4213-4222.
  • 24. Ritt P, Sanders J, Kuwert T. SPECT/CT technology. Clin Transl Imaging. 2014;2:445-457.
  • 25. Lewandowski RJ, Sato KT, Atassi B, Ryu RK, Nemcek AA, Kulik L, et al. Radioembolization with 90 Y microspheres: angiographic and technical considerations. Cardiovasc Intervent Radiol. 2007;30:571-592.
  • 26. Kim, Y., Kim, C., Lee, E., & Lee, J. W. (2024). Coronal plane in opportunistic screening of osteoporosis using computed tomography: comparison with axial and sagittal planes. Skeletal Radiology, 53(6), 1103-1109.
  • 27. Karssemakers, L. H. E., Nolte, J. W., Rehmann, C., Raijmakers, P. G., & Becking, A. G. (2023). Diagnostic performance of SPECT–CT imaging in unilateral condylar hyperplasia. International Journal of Oral and Maxillofacial Surgery, 52(2), 199-204.
  • 28. Karssemakers, L. H. E., Besseling, L. M. P., Schoonmade, L. J., Su, N., Nolte, J. W., Raijmakers, P. G., & Becking, A. G. (2024). Diagnostic accuracy of bone SPECT and SPECT/CT imaging in the diagnosis of unilateral condylar hyperplasia: A systematic review and meta-analysis. Journal of Cranio-Maxillofacial Surgery, 52(4), 447-453.
  • 29. Anzola, L. K., Venegas, N., Jaramillo, M. C., Moreno, S., Hinojosa, M., Amador, E., ... & Mut, F. (2024). Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia. Diagnostics, 14(22), 2548.
  • 30. Zhang, Y., Jiang, Z., Zhang, Y., & Ren, L. (2024). A review on 4D cone‐beam CT (4D‐CBCT) in radiation therapy: Technical advances and clinical applications. Medical physics, 51(8), 5164-5180.
  • 31. Bailey DL, Willowson KP. An evidence-based review of quantitative SPECT imaging and potential clinical applications. J Nucl Med. 2013;54:83–89. doi: 10.2967/jnumed.112.111476.
  • 32. Kim, J. Y., Lee, C., Park, Y. L., Lee, J. H., Ryu, Y. H., & Huh, J. K. (2024). Diagnostic criteria for temporomandibular joint osteoarthritis using standardized uptake value in single-photon emission computed tomography–computed tomography. Scientific Reports, 14(1), 31569.

CBCT and SPECT/CT Dose Application Correlation in TARE Treatments

Yıl 2025, Cilt: 34 Sayı: 1, 61 - 67, 31.03.2025
https://doi.org/10.17827/aktd.1604220

Öz

PURPOSE: Our study aimed to investigate the correlation between Cone Beam Computed Tomography (CBCT) and Single Photon Emission Computed Tomography/X-Ray Computed Tomography (SPECT/CT) dose application in Tare treatments.
MATERIAL-METHOD: The features and usage advantages of CBCT and SPECT/CT, which are common methods used to examine the effectiveness of microalbumin aggregate (MAA) used in transarterial radioembolization (TARE) treatments, were examined. The dose applications of CBCT and SPECT/CT were evaluated in the light of literature studies.
CONCLUSION: In recent years, it can be said that with the advanced applications and developing technology, it is beneficial to make plans in a way that will provide maximum effect and minimum side effects to patients. In recent years, studies have shown that there is a correlation between CBCT and SPECT/CT and that when planned together, the efficiency rate increases. CBCT is an important treatment support system in TARE treatments and helps to perform the treatment effectively and reliably. In addition, it is thought that supporting dual planning strategies with artificial intelligence-supported studies will minimize the indications that may occur in the form of treatment.

Kaynakça

  • 1. Kobe A, Zgraggen J, Messmer F, Puippe G, Sartoretti T, Alkadhi H, et al. Prediction of treatment response to transarterial radioembolization of liver metastases: Radiomics analysis of pre-treatment cone-beam CT: A proof of concept study. Eur J Radiol Open. 2021;8:100375.
  • 2. Rodríguez-Fraile M, Ezponda A, Grisanti F, Morán V, Calvo M, Berián P, et al. The joint use of 99m Tc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning. EJNMMI Res. 2021;11:1-11.
  • 3. Ertreo M, Choi H, Field D, Lischalk JW, Cohen E, Lynskey GE, et al. Comparison of cone-beam tomography and cross-sectional imaging for volumetric and dosimetric calculations in resin yttrium-90 radioembolization. Cardiovasc Intervent Radiol. 2018;41:1857-1866.
  • 4. O’Connor PJ, Pasik SD, van der Bom IM, Bishay V, Radaelli A, Kim E. Feasibility of yttrium-90 radioembolization dose calculation utilizing intra-procedural open trajectory cone beam CT. Cardiovasc Intervent Radiol. 2020;43:295-301.
  • 5. Zhang Y, Tehrani JN, Wang J. A biomechanical modeling guided CBCT estimation technique. IEEE Trans Med Imaging. 2016;36(2):641-652.
  • 6. Lau WY, Kennedy AS, Kim YH, Lai HK, Lee RC, Leung TW, et al. Patient selection and activity planning guide for selective internal radiotherapy with yttrium-90 resin microspheres. Int J Radiat Oncol Biol Phys. 2012;82(1):401-407.
  • 7. Gandhi SJ, Babu S, Subramanyam P, Sundaram PS. Tc-99m macro aggregated albumin scintigraphy–Indications other than pulmonary embolism: A pictorial essay. Indian J Nucl Med. 2013;28(3):152-162.
  • 8. Fukuoka M, Kobayashi T, Satoh T, Tanaka A, Akiko K. Studies of quality control of 99mTc-labelled macroaggregated albumin—Part 1. Aggregation of non-mercaptalbumin and its conformation. Nucl Med Biol. 1993;20(5):643-648.
  • 9. Villalobos A, Cheng B, Wagstaff W, Sethi I, Bercu Z, Schuster DM, et al. Tumor-to-normal ratio relationship between planning Technetium-99 macroaggregated albumin and posttherapy Yttrium-90 Bremsstrahlung SPECT/CT. J Vasc Interv Radiol. 2021;32(5):752-760.
  • 10. Canziani L, Marenco M, Cavenaghi G, Manfrinato G, Taglietti A, Girella A, et al. Chemical and Physical Characterisation of Macroaggregated Human Serum Albumin: Strength and Specificity of Bonds with 99mTc and 68Ga. Molecules. 2022;27(2):404.
  • 11. Chen G, Lu Z, Jiang H, Lin KH, Mok GS. Voxel-S-value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT. Sci Rep. 2023;13(1):4020.
  • 12. Tabotta F, Gnesin S, Dunet V, Ponti A, Digklia A, Boughdad S, et al. 99mTc-macroaggregated albumin SPECT/CT predictive dosimetry and dose-response relationship in uveal melanoma liver metastases treated with first-line selective internal radiation therapy. Sci Rep. 2023;13(1):13118.
  • 13. Doyle PW, Workman CS, Grice JV, McGonigle TW, Huang S, Borgmann AJ, et al. Predictive Dosimetry and Outcomes of Hepatocellular Carcinoma Treated by Yttrium-90 Resin Microsphere Radioembolization: A Retrospective Analysis Using Technetium-99m Macroaggregated Albumin SPECT/CT and Planning Software. J Vasc Interv Radiol. 2024;35(5):689-698.
  • 14. Kumar M, Shanavas M, Sidappa A, Kiran M. Cone beam computed tomography-know its secrets. J Int Oral Health. 2015;7(2):64.
  • 15. Walter C, Schmidt JC, Rinne CA, Mendes S, Dula K, Sculean A. Cone beam computed tomography (CBCT) for diagnosis and treatment planning in periodontology: systematic review update. Clin Oral Investig. 2020;24:2943-2958.
  • 16. Fiore F, Somma F, D’Angelo R, Tarotto L, Stoia V. Cone beam computed tomography (CBCT) guidance is helpful in reducing dose exposure to pediatric patients undergoing radiofrequency ablation of osteoid osteoma. Radiol Med. 2022;127(2):183-190.
  • 17. Alshomrani F. Cone-Beam Computed Tomography (CBCT)-Based Diagnosis of Dental Bone Defects. Diagnostics. 2024;14(13):1404.
  • 18. Rashid A, Feinberg L, Fan K. The Application of Cone Beam Computed Tomography (CBCT) on the Diagnosis and Management of Maxillofacial Trauma. Diagnostics. 2024;14(4):373.
  • 19. Ritt P. Recent developments in SPECT/CT. Semin Nucl Med. 2022;52(3):276-285.
  • 20. Dietze MM, Kunnen B, Van Der Velden S, Steenbergen JL, Koppert WJ, Viergever MA, et al. Performance of a dual-layer scanner for hybrid SPECT/CBCT. Phys Med Biol. 2019;64(10):105020.
  • 21. Römer W, Reichel N, Vija HA, Nickel I, Hornegger J, Bautz W, et al. Isotropic reconstruction of SPECT data using OSEM3D: correlation with CT. Acad Radiol. 2006;13(4):496-502.
  • 22. Geworski L, Knoop BO, de Cabrejas ML, Knapp WH, Munz DL. Recovery correction for quantitation in emission tomography: a feasibility study. Eur J Nucl Med. 2000;27:161-169.
  • 23. Malina-Altzinger J, Klaeser B, Suter VG, Schriber M, Vollnberg B, Schaller B. Comparative evaluation of SPECT/CT and CBCT in patients with mandibular osteomyelitis and osteonecrosis. Clin Oral Investig. 2019;23:4213-4222.
  • 24. Ritt P, Sanders J, Kuwert T. SPECT/CT technology. Clin Transl Imaging. 2014;2:445-457.
  • 25. Lewandowski RJ, Sato KT, Atassi B, Ryu RK, Nemcek AA, Kulik L, et al. Radioembolization with 90 Y microspheres: angiographic and technical considerations. Cardiovasc Intervent Radiol. 2007;30:571-592.
  • 26. Kim, Y., Kim, C., Lee, E., & Lee, J. W. (2024). Coronal plane in opportunistic screening of osteoporosis using computed tomography: comparison with axial and sagittal planes. Skeletal Radiology, 53(6), 1103-1109.
  • 27. Karssemakers, L. H. E., Nolte, J. W., Rehmann, C., Raijmakers, P. G., & Becking, A. G. (2023). Diagnostic performance of SPECT–CT imaging in unilateral condylar hyperplasia. International Journal of Oral and Maxillofacial Surgery, 52(2), 199-204.
  • 28. Karssemakers, L. H. E., Besseling, L. M. P., Schoonmade, L. J., Su, N., Nolte, J. W., Raijmakers, P. G., & Becking, A. G. (2024). Diagnostic accuracy of bone SPECT and SPECT/CT imaging in the diagnosis of unilateral condylar hyperplasia: A systematic review and meta-analysis. Journal of Cranio-Maxillofacial Surgery, 52(4), 447-453.
  • 29. Anzola, L. K., Venegas, N., Jaramillo, M. C., Moreno, S., Hinojosa, M., Amador, E., ... & Mut, F. (2024). Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia. Diagnostics, 14(22), 2548.
  • 30. Zhang, Y., Jiang, Z., Zhang, Y., & Ren, L. (2024). A review on 4D cone‐beam CT (4D‐CBCT) in radiation therapy: Technical advances and clinical applications. Medical physics, 51(8), 5164-5180.
  • 31. Bailey DL, Willowson KP. An evidence-based review of quantitative SPECT imaging and potential clinical applications. J Nucl Med. 2013;54:83–89. doi: 10.2967/jnumed.112.111476.
  • 32. Kim, J. Y., Lee, C., Park, Y. L., Lee, J. H., Ryu, Y. H., & Huh, J. K. (2024). Diagnostic criteria for temporomandibular joint osteoarthritis using standardized uptake value in single-photon emission computed tomography–computed tomography. Scientific Reports, 14(1), 31569.
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Derleme
Yazarlar

Serdar Davran 0009-0005-4097-7777

Ferhat Can Pişkin 0000-0003-4092-1077

Ebru Şimşek 0000-0003-0351-3883

Hıdır Şimşek Bu kişi benim 0000-0001-9136-0543

Erken Görünüm Tarihi 25 Mart 2025
Yayımlanma Tarihi 31 Mart 2025
Gönderilme Tarihi 24 Aralık 2024
Kabul Tarihi 18 Şubat 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 34 Sayı: 1

Kaynak Göster

AMA Davran S, Pişkin FC, Şimşek E, Şimşek H. TARE Tedavilerinde CBCT ve SPECT/CT Doz Uygulama Korelasyonu. aktd. Mart 2025;34(1):61-67. doi:10.17827/aktd.1604220