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Gonartroz Ağrısında Alternatif Tıp Tedavileri

Yıl 2025, Cilt: 34 Sayı: 3, 243 - 252, 30.09.2025
https://doi.org/10.17827/aktd.1548783

Öz

Osteoartrit, eklem kıkırdağının peyderpey bozulmasıyla karakterize en yaygın bir eklem hastalığıdır; osteoartritte yalnızca eklem kıkırdağı değil aynı zamanda sinoviyum, subkondral kemik, eklem kapsülü, bağlar, periartiküler kaslar ve sinirler de dahil olmak üzere eklem çevresindeki tüm dokular da etkilenir ve ağrıya katkıda bulunur. Dizde görüldüğünde gonartroz olarak adlandırılır. Hastalığın ileri evrelerinde nihai tedavi cerrahidir ancak bu evreden önce hastalar tekrar tekrar hekimlere başvurur ve yıllarca çeşitli ağrı giderici yöntemleri denerler. Sonuç olarak tıbbi tedavi seçenekleri tükenebilir ve bazen çaresizce alternatif yöntemlere başvururlar.
Bu derlemede gonartroz hastalarında ağrının azaltılmasına yönelik alternatif tıp yöntemleri gözden geçirilmiştir. Doku içi madde enjeksiyonu ile proloterapi, kimyasal dengeleri değiştirme potansiyeli olan radyoterapi ve ozon uygulamaları etki mekanizmalarının mantık dahilinde olması ve güvenli yan etki profilleri açısından makul bulunmuştur. Ancak, potansiyel enfeksiyon riskleri nedeniyle ıslak hacamat ve sülük tedavisi uygun görülmemiştir. Akupunktur ve refleksoloji gibi etki mekanizmaları mantıktan uzak ve bilimsel olarak desteklenemeyen kadim uygulamalar eleştirilmiştir. Homeopati bir nevi şarlatanlık olarak ele alınmış, abartılı vaatlerle her şeyi tedavi ettiğini iddia eden ilaçlara karşı dikkatli olunması tavsiye edilmiştir.
Gerçekler ve yalanların iç içe girmesini eleştiren makale, hekimlerin etik sorumluluğunun bilimsel gerçeklere göre hareket etmenin yanısıra, hastaların endişelerini gidermeyi, onları rahatlatmayı ve tatmin etmeyi de içerdiğine vurgu yapmaktadır. Derleme, alternatif tıbbın yalnızca bu gibi teskin edici bazı amaçlar için değerlendirilmesi gerektiği sonucuna varmakta aslen ihtiyatlı ve kanıta dayalı yaklaşımları önermektedir.

Kaynakça

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  • 3. Tıbbi Deontoloji Nizamnamesi (1960, 19 Şubat). Resmî Gazete (Karar No: 12578, Sayı: 10436). https://www.resmigazete.gov.tr/arsiv/10436.pdf
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  • 9. Micke O, Ugrak E, Bartmann S, et al. Radiotherapy for calcaneodynia, achillodynia, painful gonarthrosis, bursitis trochanterica, and painful shoulder syndrome - Early and late results of a prospective clinical quality assessment. Radiat Oncol. 2018;13(1):71.
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  • 25. Hashemi M, Jalili P, Mennati S, et al. The Effects of Prolotherapy With Hypertonic Dextrose Versus Prolozone (Intraarticular Ozone) in Patients With Knee Osteoarthritis. Anesth Pain Med. 2015;5(5)
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  • 33. Akcali, D., İnan, N., Vurallı, D., Dayanır, H., & Babacan, A. (2016). Gonartroz Hastalarında İntraartiküler Ozon Enjeksiyonunun Ağrıya Etkisi. Gazi Medical Journal, 27(3).
  • 34. Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S, Kesiktas FN. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Knee Surg Sports Traumatol Arthrosc. 2017;25(2):485-492.
  • 35. Sconza C, Respizzi S, Virelli L, et al. Oxygen–ozone therapy for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2020;36(1):277-286.
  • 36. Wang H, Zhang J, Chen L. The efficacy and safety of medical leech therapy for osteoarthritis of the knee: A meta-analysis of randomized controlled trials. International Journal of Surgery. 2018;54:53-61.
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  • 38. Park JH, Yim BK, Lee JH, Lee S, Kim TH. Risk associated with bee venom therapy: a systematic review and meta-analysis. PLoS ONE. 2015;10(5)
  • 39. Jagua-Gualdrón A, Peña-Latorre JA, Fernadez-Bernal RE. Apitherapy for osteoarthritis: perspectives from basic research. Complement Med Res. 2020;27(3):184-192.
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Alternative Medicine for Gonarthrosis Pain

Yıl 2025, Cilt: 34 Sayı: 3, 243 - 252, 30.09.2025
https://doi.org/10.17827/aktd.1548783

Öz

Osteoarthritis is the most common joint disorder characterized by the gradual deterioration of articular cartilage, in osteoarthritis, not only the joint cartilage, but also all surrounding tissues, including the synovium, subchondral bone, joint capsule, ligaments, periarticular muscles, and nerves are affected and contribute to the pain. The knee is the most common location for this disease, known as gonarthrosis. In late stages of the disease surgery is the ultimate treatment however before that stage patients seek pain relieving methods for years resulting in repeated trips to physicians. Eventually, they may run out of treatment options and feel desperate.
This review investigates the methods of alternative-medicine for alleviating pain in gonarthrosis patients. Alternative treatments, including prolotherapy with intra-tissue substance injection, radiotherapy, and ozone therapy for modifying chemical balances, are explored for their plausibility and safe side effect profiles. However, the review discourages wet-cupping and leech therapy due to potential infection risks. Ancient practices like acupuncture and reflexology, lacking scientific backing for their mechanisms of action, criticized. Homeopathy is categorically dismissed as quackery, and caution is advised against cure-all drugs with extravagant promises.
Navigating the intricate interplay of facts and lies, the article underscores the ethical responsibility of physicians, emphasizing the application of scientific truths and the art of medicine which also consist of addressing the patients concerns, reassuring and satisfying them. The review concludes that alternative-medicine should be considered within the medical realm solely for those specific purposes, urging a cautious and evidence-based approach.

Kaynakça

  • 1. Alternative medicine. Wikipedia. February 20, 2024. Accessed March 6, 2024. https://en.wikipedia.org/wiki/Alternative_medicine.
  • 2. Wang WY, Zhou H, Wang YF, Sang BS, Liu L. Current policies and measures on the development of traditional chinese medicine in china. Pharmacological Research. 2021;163:105187.
  • 3. Tıbbi Deontoloji Nizamnamesi (1960, 19 Şubat). Resmî Gazete (Karar No: 12578, Sayı: 10436). https://www.resmigazete.gov.tr/arsiv/10436.pdf
  • 4. Dove APH, Cmelak A, Darrow K, et al. The use of low-dose radiation therapy in osteoarthritis: a review. International Journal of Radiation Oncology*Biology*Physics. 2022;114(2):203-220.
  • 5. Hautmann MG, Rechner P, Neumaier U, et al. Radiotherapy for osteoarthritis—an analysis of 295 joints treated with a linear accelerator. Strahlenther Onkol. 2020;196(8):715-724.
  • 6. Álvarez B, Montero Á, Aramburu F, et al. Radiotherapy for ostheoarticular degenerative disorders: When nothing else works. Osteoarthritis and Cartilage Open. 2020;1(3-4)
  • 7. Mücke R, Seegenschmiedt MH, Heyd R, et al. [Radiotherapy in painful gonarthrosis. Results of a national patterns-of-care study]. Strahlenther Onkol. 2010;186(1):7-17.
  • 8. Keller S, Müller K, Kortmann RD, et al. Efficacy of low-dose radiotherapy in painful gonarthritis: experiences from a retrospective East German bicenter study. Radiat Oncol. 2013;8:29
  • 9. Micke O, Ugrak E, Bartmann S, et al. Radiotherapy for calcaneodynia, achillodynia, painful gonarthrosis, bursitis trochanterica, and painful shoulder syndrome - Early and late results of a prospective clinical quality assessment. Radiat Oncol. 2018;13(1):71.
  • 10. Montero A, Sabater S, Rödel F, et al. Is it time to redefine the role of low-dose radiotherapy for benign disease? Ann Rheum Dis. 2020;79(3):e34-e34.
  • 11. Mahler EAM, Minten MJ, Leseman-Hoogenboom MM, et al. Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis: a randomised, double-blinded, sham-controlled trial. Ann Rheum Dis. Published online October 26, 2018:annrheumdis-2018-214104.
  • 12. van den Ende CHM, Minten MJM, Leseman-Hoogenboom MM, et al. Long-term efficacy of low-dose radiation therapy on symptoms in patients with knee and hand osteoarthritis: follow-up results of two parallel randomised, sham-controlled trials. The Lancet Rheumatology. 2020;2(1):e42-e49.
  • 13. Minten MJM, Mahler E, den Broeder AA, Leer JWH, van den Ende CH. The efficacy and safety of low-dose radiotherapy on pain and functioning in patients with osteoarthritis: a systematic review. Rheumatol Int. 2016;36(1):133-142.
  • 14. Weissmann T, Rückert M, Putz F, et al. Low-dose radiotherapy of osteoarthritis: from biological findings to clinical effects—challenges for future studies. Strahlenther Onkol. 2023;199(12):1164-1172.
  • 15. Niewald M, Moumeniahangar S, Müller LN, et al. ArthroRad trial: randomized multicenter single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis—final results after 12-month follow-up. Strahlenther Onkol. 2024;200(2):134-142.
  • 16. Arias-Vázquez PI. Intra-articular injections for treating knee osteoarthritis: a classification according to their mechanism of action. J Clin Rheumatol. Published online April 10, 2024.
  • 17. Rabago D, Slattengren A, Zgierska A. Prolotherapy in primary care practice. Prim Care. 2010;37(1):65-80.
  • 18. Sells P, Vayster A, Hinkelman A, et al. The efficacy of phenol-glucose-glycerin mixtures as a prolotherapy proliferative substance on fibroblast tissue culture. The Journal of Pain. 2024;25(4):22.
  • 19. Vomer RP, Larick RS, Milon R, York E. The effect of intra-articular hypertonic dextrose prolotherapy on pain, quality of life, and functional outcomes scores in patients with knee osteoarthritis. Cureus. Published online November 1, 2023.
  • 20. Avşar MT, Okudan RN, Gümüş ZZ, Samanci̇ R. Efficacy of prolotherapy with periarticular 5% dextrose in the treatment of knee joint osteoarthritis. International Journal of Traditional and Complementary Medicine Research. 2021;2(3):162-166.
  • 21. Sit RW, Chung VCh, Reeves KD, et al. Hypertonic dextrose injections (prolotherapy) in the treatment of symptomatic knee osteoarthritis: A systematic review and meta-analysis. Sci Rep. 2016;6:252-47.
  • 22. Bae G, Kim S, Lee S, Lee WY, Lim Y. Prolotherapy for the patients with chronic musculoskeletal pain: systematic review and meta-analysis. Anesth Pain Med. 2021;16(1):81-95.
  • 23. Hassan F, Trebinjac S, Murrell WD, Maffulli N. The effectiveness of prolotherapy in treating knee osteoarthritis in adults: a systematic review. Br Med Bull. 2017;122(1):91-108.
  • 24. Wee TC, Neo EJR, Tan YL. Dextrose prolotherapy in knee osteoarthritis: A systematic review and meta-analysis. Journal of Clinical Orthopaedics and Trauma. 2021;19:108-117.
  • 25. Hashemi M, Jalili P, Mennati S, et al. The Effects of Prolotherapy With Hypertonic Dextrose Versus Prolozone (Intraarticular Ozone) in Patients With Knee Osteoarthritis. Anesth Pain Med. 2015;5(5)
  • 26. Waluyo Y, Artika SR, Insani Nanda Wahyuni, Gunawan AMAK, Zainal ATF. Efficacy of prolotherapy for osteoarthritis: a systematic review. JRM. 2023;55:jrm00372.
  • 27. Chen Y-W, Lin Y-N, Chen H-C, Liou T-H, Liao C-D, Huang S-W. Effectiveness, Compliance, and Safety of Dextrose Prolotherapy for Knee Osteoarthritis: A Meta-Analysis and Metaregression of Randomized Controlled Trials. Clinical Rehabilitation. 2022;36(6):740-752.
  • 28. Hassan F, Murrell WD, Refalo A, Maffulli N. Alternatives to biologics in management of knee osteoarthritis: a systematic review. Sports Medicine and Arthroscopy Review. 2018;26(2):79-85.
  • 29. Chen L, Li D, Zhong J, Qiu B, Wu X. Erratum to "Therapeutic Effectiveness and Safety of Mesotherapy in Patients with Osteoarthritis of the Knee". Evid Based Complement Alternat Med. 2018
  • 30. Mammucari M, Gatti A, Maggiori S, Sabato AF. Role of mesotherapy in musculoskeletal pain: opinions from the italian society of mesotherapy. Evid Based Complement Alternat Med. 2012;:43-69.
  • 31. Faetani L, Ghizzoni D, Ammendolia A, Costantino C. Safety and efficacy of mesotherapy in musculoskeletal disorders: A systematic review of randomized controlled trials with meta-analysis. J Rehabil Med. 2021;53(4):jrm00182.
  • 32. Lopes de jesus CC, Dos santos FC, De jesus LMOB, Monteiro I, Sant'ana MSSC, Trevisani VFM. Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: A randomized, double-blinded, placebo-controlled study. PLoS ONE. 2017;12(7)
  • 33. Akcali, D., İnan, N., Vurallı, D., Dayanır, H., & Babacan, A. (2016). Gonartroz Hastalarında İntraartiküler Ozon Enjeksiyonunun Ağrıya Etkisi. Gazi Medical Journal, 27(3).
  • 34. Duymus TM, Mutlu S, Dernek B, Komur B, Aydogmus S, Kesiktas FN. Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options. Knee Surg Sports Traumatol Arthrosc. 2017;25(2):485-492.
  • 35. Sconza C, Respizzi S, Virelli L, et al. Oxygen–ozone therapy for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2020;36(1):277-286.
  • 36. Wang H, Zhang J, Chen L. The efficacy and safety of medical leech therapy for osteoarthritis of the knee: A meta-analysis of randomized controlled trials. International Journal of Surgery. 2018;54:53-61.
  • 37. Curcio J, Lloyd CM. Leech me alone! Atraumatic hemarthrosis after hirudotherapy. Cureus. Published online February 7, 2020.
  • 38. Park JH, Yim BK, Lee JH, Lee S, Kim TH. Risk associated with bee venom therapy: a systematic review and meta-analysis. PLoS ONE. 2015;10(5)
  • 39. Jagua-Gualdrón A, Peña-Latorre JA, Fernadez-Bernal RE. Apitherapy for osteoarthritis: perspectives from basic research. Complement Med Res. 2020;27(3):184-192.
  • 40. Gu JH, Kim E, Park YC, Jung IC, Lee EJ. A systematic review of bee venom acupuncture for knee osteoarthritis. J Korean Med Rehabil. 2017;27(3):47-60.
  • 41. Mohamed AA, Zhang X, Jan YK. Evidence-based and adverse-effects analyses of cupping therapy in musculoskeletal and sports rehabilitation: A systematic and evidence-based review. BMR. 2023;36(1):3-19.,
  • 42. Azizkhani M, Ghorat F, Soroushzadeh SMA, Karimi M, Yekaninejad S. The effect of cupping therapy on non-specific neck pain: a systematic review and meta-analysis. Iran Red Crescent Med J. 2017;20(7).
  • 43. Derry C, Derry S, McQuay H, Moore R. Systematic review of systematic reviews of acupuncture published 1996–2005. Clin Med. 2006;6(4):381-386.
  • 44. Araya-Quintanilla F, Cuyúl-Vásquez I, Gutiérrez-Espinoza H. Does acupuncture provide pain relief in patients with osteoarthritis knee? An overview of systematic reviews. Journal of Bodywork and Movement Therapies. 2022;29:117-126.
  • 45. Ezzo J, Berman B, Hadhazy VA, Jadad AR, Lao L, Singh BB. Is acupuncture effective for the treatment of chronic pain? A systematic review. Pain. 2000;86(3):217-225.
  • 46. Madsen MV, Gotzsche PC, Hrobjartsson A. Acupuncture treatment for pain: systematic review of randomised clinical trials with acupuncture, placebo acupuncture, and no acupuncture groups. BMJ. 2009;338:a3115-a3115.
  • 47. Kaptchuk TJ. Placebo effects in acupuncture. Medical Acupuncture. 2020;32(6):352-356.
  • 48. Faydaoğlu, E., & Sürücüoğlu, M. S. (2011). Geçmişten Günümüze Tıbbi ve Aromatik Bitkilerin Kullanılması ve Ekonomik Önemi. Kastamonu University Journal of Forestry Faculty, 11(1), 52-67.
  • 49. Külekçi̇oğlu S. Traditional and complementary medicine use for knee osteoarthritis. The European Research Journal. 2022;8(5):619-628.
  • 50. Long L, Soeken K, Ernst E. Herbal medicines for the treatment of osteoarthritis: a systematic review. Rheumatology. 2001;40(7):779-793.
  • 51. Dragos D, Gilca M, Gaman L, et al. Phytomedicine in joint disorders. Nutrients. 2017;9(1):70.
  • 52. Ganguly A. Topical Phytotherapy is the Nobel Approach for Revision of Total Knee Replacement: A Unique Case Study J Orthopedics Rheumatol. 2018; 5(1): 6.
  • 53. Terzi̇ A, Gebressalesie HT, Yildirim Y. Aromatherapy interventions in elderly person: a systematic review. J Tradit Complem Med. 2020;3(3):293-303.
  • 54. Borkens Y, Endruscheit U, Lübbers CW. Homeopathy—A lively relic of the prescientific era. Wien Klin Wochenschr. 2024;136(5-6):177-184.
  • 55. Smith K. Against homeopathy – a utilitarian perspective. Bioethics. 2012;26(8):398-409.
  • 56. Leemhuis H, Seifert R. Prescriptions of homeopathic remedies at the expense of the German statutory health insurance from 1985 to 2021: scientific, legal and pharmacoeconomic analysis. Naunyn-Schmiedeberg’s Arch Pharmacol. Published online March 2, 2024.
  • 57. Shaw DM. Homeopathy is where the harm is: five unethical effects of funding unscientific 'remedies'. J Med Ethics. 2010;36(3):130-1.
  • 58. Ernst E. A systematic review of systematic reviews of homeopathy. British Journal of Clinical Pharmacology. 2002;54(6):577-582.
  • 59. Ernst E. Homeopathy: what does the “best” evidence tell us? Medical Journal of Australia. 2010;192(8):458-460.
  • 60. Mathie RT, Ramparsad N, Legg LA, et al. Randomised, double-blind, placebo-controlled trials of non-individualised homeopathic treatment: systematic review and meta-analysis. Syst Rev. 2017;6(1):63.
  • 61. Wikipedia, the free encyclopedia. Patent medicine. Available at: https://en.wikipedia.org/wiki/Patent_medicine#Ingredients_and_their_uses. Accessed March 4, 2024
  • 62. Nural N, Çakmak S. Status of using complementary and alternative treatments of individuals with chronic disease. J Tradit Complem Med. 2018;1(1):1-9.
  • 63. Forestier R, Erol Forestier FB, Francon A. Spa therapy and knee osteoarthritis: A systematic review. Annals of Physical and Rehabilitation Medicine. 2016;59(3):216-226.
  • 64. Lee YS, Jung WM, Bingel U, Chae Y. The context of values in pain control: understanding the price effect in placebo analgesia. The Journal of Pain. 2020;21(7-8):781-789. (pahalı placebo daha yararlı)
  • 65. Kaptchuk TJ, Miller FG. Placebo effects in medicine. N Engl J Med. 2015;373(1):8-9.
  • 66. Colloca L. The placebo effect in pain therapies. Annu Rev Pharmacol Toxicol. 2019;59:191-211.
Toplam 66 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Cerrahi (Diğer)
Bölüm Derleme
Yazarlar

Ahmet Issın 0000-0002-3084-0372

Erken Görünüm Tarihi 24 Eylül 2025
Yayımlanma Tarihi 30 Eylül 2025
Gönderilme Tarihi 20 Eylül 2024
Kabul Tarihi 24 Temmuz 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 34 Sayı: 3

Kaynak Göster

AMA Issın A. Gonartroz Ağrısında Alternatif Tıp Tedavileri. aktd. Eylül 2025;34(3):243-252. doi:10.17827/aktd.1548783