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VÜCUT BİLEŞİMLERİ SAPTANAN ÖĞRENCİLERİN İMMÜN SİSTEMLERİNİN LÖKOSİT FORMÜLÜ İLE DEĞERLENDİRİLMESİ

Yıl 2017, Cilt: 1 Sayı: 1, 5 - 9, 31.07.2017

Öz

Amaç:
Bu çalışma aile
ortamından uzak olup mevcut beslenme alışkanlıklarına bağlı olarak vücut
bileşimleri değişen üniversite öğrencilerinin immün sistemlerini
değerlendirmeyi amaçlamaktadır.

Materyal
ve Metot:
Vücut analizleri yapılan 46
üniversite öğrencisinin toplam vücut yağ yüzdesine ilişkin değerler
kaydedilerek normal, düşük ve yüksek yağ yüzdesine sahip olan 3 grup
oluşturuldu. Bu gruplardaki her bir öğrenciden kan alınarak frotileri
hazırlandı ve formül lökositleri çıkarıldı.

Bulgular: Yapılan
istatistiki değerlendirme sonucunda diğer gruplara göre yağ yüzdesi yüksek olan
grubun monosit oranında önemli bir artış olduğu görüldü (p<0,05).







Sonuç: Bu hücre sayısındaki artış yağ dokusundaki makrofaj
birikimine ve dolayısıyla da inflamasyonun olduğuna işaret etmektedir

Kaynakça

  • 1. Kelly J. Understanding the immun system how it works. 1st ed. Nih Publication; 2007.p.1-54.
  • 2. Parkin J, Cohen B. An overview of the immun system. Immunology. 2001; 357:1777-1789.
  • 3. Strandberg L. Interactions between nutrition, obesity and the immune system. Intellecta Infolog, Gothenburg University, Sweden; 2009.p.1-72.
  • 4. Büyükçoşkun N. http://www.tip.uludag.edu.tr/temel-tip-bilimleri/fizyoloji/edinsel-bagişiklik-mekanizmasi.pdf.2009-2010. (Erişim tarihi: 14 Haziran 2017)
  • 5. Delves PJ, Roitt IM. The immune system. Part 1. N Engl J Med. 2000;343:3-49.
  • 6. Delves PJ, Roitt IM. The immune system. Part 2. N Engl J Med. 2000;343:108-117.
  • 7. Schrauwen P, Westerterp, KR. The role of high-fat diets and physical activity in the regulation of body weight. Br J Nutr. 2000;84:417-427.
  • 8. Dönmez M, Cankurtaran M, İlseven S, Sancak N, İpekçioğlu P, Turan AR. Diyet lifleri ve insan sağlığı üzerindeki etkileri. Ulusal Meslek YO Öğrenci Sempozyumu, Düzce, 2010.
  • 9. Duncan BB, Schmidt MI. Chronic activation of the innate immune system may underlie the metabolic sendrom. Sao Paulo Med J. 2001; 119(3: 122-127.
  • 10. Mehta S, Farmer JA. Obesity and inflammation: a new look at an old problem. Curr Atheroscler Rep. 2007;9(2):134-138.
  • 11. Sorisky A, Gagnon A. Clinical implications of adipose tissue. Canadian Journal of Diabetes. 2002;26(3):232-240
  • 12. Wisse BE, Kim F, Schwartz MW. Physiology . An integrative viwe of obesity. Science. 2007;318(5852):928-929.
  • 13. Stanley S, Wynne K, Mcgowan B, Bloom S. Hormonal regulation of food intake. Physiol Rev. 2005;85:1131-1158.
  • 14. Li Q, Chen R, Moriya J, Yamakawa J, Sumino H, Kanda T, et al. Novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity. The Journal of International Medical Researc. 2008,36:625-629.
  • 15. Hekimoğlu A. Leptin ve fizyopatolojik olaylardaki rolü. Dicle Tıp Dergisi. 2006;33(4): 259-267.
  • 16. Considine RV, Sinha MK, Heinman ML, Kriaucianus A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal weight and obese human. N Engl J Med. 1996 334: 292-295.
  • 17. Fantuzzi G, Faggioni R. Leptin in the regulation of immunityi inflammation, and hematopoiesis. J Leukoc Biol. 2000; 68: 437-446.
  • 18. Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000; 269: 543-546.
  • 19. Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodefiency of malnutrion. The Faseb Journal. 2001; 15: 2565-2571.
  • 20. Martin- Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol. 2000; 199: 15-24.
  • 21. Cousin B, Munoz O, Andre M, Fontanilles AM, Dani C, Cousin JL et al. A role for preadipocytes as macrophage-like cells. Faseb J. 1999; 13(2): 305-312.
  • 22. Robker RL, Collins RG, Beaudet AL, Mersmann HJ, Smith CW. Leukocyte migration in adipose tissue of mice null for ICAM-1 and Mac-1 adhesion receptors. Obes Res. 2004; 12(6): 936-940.
  • 23. Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring HU. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia. 1997; 40: 1358-1362.
  • 24.Sur E, Çelik İ, Öznurlu Y, Aydın MF. Genç ve ergin sülünlerin (Phasianus Colchicus) perifer kan lökosit oranları ile lenfositlerin alfa-naftil asetat estreaz (ANAE) aktivitelerinin belirlenmesi. Vet Bil Derg. 2004; 20(3): 87-93.
  • 25. Konuk T. Pratik Fizyoloji. AÜ Vet Fak Yayın, Ankara. 1981.p.378.
  • 26. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nature. 2005; 5: 953-964.
  • 27. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet induced resistance to leptin action. Nat Med. 1995; 1: 1311-1314.
  • 28. Maffei M, Fei H, Lee GH, Dani C, Leroy P, Zhang Y et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA. 1995; 92: 6957-6960.
  • 29. Gainsford T, Wilson TA, Metcalf D, Haldman E, Mc Farlane C, Nf A et al. Leptin can induce proliferation, differantiation, and functional activation of hemopoetic cells. Proc Natl Acad Sci USA. 1996;93:14564-14568.
  • 30. Zarkesh E, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A et al. High-dose leptin activates human leucocytes via receptor expression on monocytes. J Immunol. 2001; 167:4593-4599.

EVALUATION OF THE IMMUNE SYSTEMS OF STUDENTS DETECTING BODY COMPOUNDS WITH LEUKOCYTE FORMULA

Yıl 2017, Cilt: 1 Sayı: 1, 5 - 9, 31.07.2017

Öz

Aim: The purpose of this study is to evaluate the effects
of body composition on the immune system in students who are distant from the
families and, depending on changing dietary habits.

Material and Method: The body analyzes of 46
university students were made. As a result of the analysis, the values related
to the total body fat percentage were recorded and 3 groups having normal, low
and high fat percentage were formed. Blood samples were taken from these
students. Smear was pulled, and formula leukocytes were calculated.

Results: In the group with high fat percentage, statistically
significant increase in the monocytes was found to be different (p<0.05)
compared to the other groups.

Conclusion: High monocyte counts of
high body fat percentage indicate macrophage accumulation and inflammation in
fat tissue.

Kaynakça

  • 1. Kelly J. Understanding the immun system how it works. 1st ed. Nih Publication; 2007.p.1-54.
  • 2. Parkin J, Cohen B. An overview of the immun system. Immunology. 2001; 357:1777-1789.
  • 3. Strandberg L. Interactions between nutrition, obesity and the immune system. Intellecta Infolog, Gothenburg University, Sweden; 2009.p.1-72.
  • 4. Büyükçoşkun N. http://www.tip.uludag.edu.tr/temel-tip-bilimleri/fizyoloji/edinsel-bagişiklik-mekanizmasi.pdf.2009-2010. (Erişim tarihi: 14 Haziran 2017)
  • 5. Delves PJ, Roitt IM. The immune system. Part 1. N Engl J Med. 2000;343:3-49.
  • 6. Delves PJ, Roitt IM. The immune system. Part 2. N Engl J Med. 2000;343:108-117.
  • 7. Schrauwen P, Westerterp, KR. The role of high-fat diets and physical activity in the regulation of body weight. Br J Nutr. 2000;84:417-427.
  • 8. Dönmez M, Cankurtaran M, İlseven S, Sancak N, İpekçioğlu P, Turan AR. Diyet lifleri ve insan sağlığı üzerindeki etkileri. Ulusal Meslek YO Öğrenci Sempozyumu, Düzce, 2010.
  • 9. Duncan BB, Schmidt MI. Chronic activation of the innate immune system may underlie the metabolic sendrom. Sao Paulo Med J. 2001; 119(3: 122-127.
  • 10. Mehta S, Farmer JA. Obesity and inflammation: a new look at an old problem. Curr Atheroscler Rep. 2007;9(2):134-138.
  • 11. Sorisky A, Gagnon A. Clinical implications of adipose tissue. Canadian Journal of Diabetes. 2002;26(3):232-240
  • 12. Wisse BE, Kim F, Schwartz MW. Physiology . An integrative viwe of obesity. Science. 2007;318(5852):928-929.
  • 13. Stanley S, Wynne K, Mcgowan B, Bloom S. Hormonal regulation of food intake. Physiol Rev. 2005;85:1131-1158.
  • 14. Li Q, Chen R, Moriya J, Yamakawa J, Sumino H, Kanda T, et al. Novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity. The Journal of International Medical Researc. 2008,36:625-629.
  • 15. Hekimoğlu A. Leptin ve fizyopatolojik olaylardaki rolü. Dicle Tıp Dergisi. 2006;33(4): 259-267.
  • 16. Considine RV, Sinha MK, Heinman ML, Kriaucianus A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal weight and obese human. N Engl J Med. 1996 334: 292-295.
  • 17. Fantuzzi G, Faggioni R. Leptin in the regulation of immunityi inflammation, and hematopoiesis. J Leukoc Biol. 2000; 68: 437-446.
  • 18. Ahima RS, Flier JS. Leptin. Annu Rev Physiol. 2000; 269: 543-546.
  • 19. Faggioni R, Feingold KR, Grunfeld C. Leptin regulation of the immune response and the immunodefiency of malnutrion. The Faseb Journal. 2001; 15: 2565-2571.
  • 20. Martin- Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol. 2000; 199: 15-24.
  • 21. Cousin B, Munoz O, Andre M, Fontanilles AM, Dani C, Cousin JL et al. A role for preadipocytes as macrophage-like cells. Faseb J. 1999; 13(2): 305-312.
  • 22. Robker RL, Collins RG, Beaudet AL, Mersmann HJ, Smith CW. Leukocyte migration in adipose tissue of mice null for ICAM-1 and Mac-1 adhesion receptors. Obes Res. 2004; 12(6): 936-940.
  • 23. Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring HU. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia. 1997; 40: 1358-1362.
  • 24.Sur E, Çelik İ, Öznurlu Y, Aydın MF. Genç ve ergin sülünlerin (Phasianus Colchicus) perifer kan lökosit oranları ile lenfositlerin alfa-naftil asetat estreaz (ANAE) aktivitelerinin belirlenmesi. Vet Bil Derg. 2004; 20(3): 87-93.
  • 25. Konuk T. Pratik Fizyoloji. AÜ Vet Fak Yayın, Ankara. 1981.p.378.
  • 26. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nature. 2005; 5: 953-964.
  • 27. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet induced resistance to leptin action. Nat Med. 1995; 1: 1311-1314.
  • 28. Maffei M, Fei H, Lee GH, Dani C, Leroy P, Zhang Y et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA. 1995; 92: 6957-6960.
  • 29. Gainsford T, Wilson TA, Metcalf D, Haldman E, Mc Farlane C, Nf A et al. Leptin can induce proliferation, differantiation, and functional activation of hemopoetic cells. Proc Natl Acad Sci USA. 1996;93:14564-14568.
  • 30. Zarkesh E, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A et al. High-dose leptin activates human leucocytes via receptor expression on monocytes. J Immunol. 2001; 167:4593-4599.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Bölüm Makaleler
Yazarlar

Fatma Çolakoğlu

Yayımlanma Tarihi 31 Temmuz 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 1 Sayı: 1

Kaynak Göster

APA Çolakoğlu, F. (2017). VÜCUT BİLEŞİMLERİ SAPTANAN ÖĞRENCİLERİN İMMÜN SİSTEMLERİNİN LÖKOSİT FORMÜLÜ İLE DEĞERLENDİRİLMESİ. Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 1(1), 5-9.