Dirençli Gram pozitif bakteriyel enfeksiyonlarinda kullanilan oksazolidinon grubu bir antibiyotik: linezolid

Yıl 2019, Cilt: 1 Sayı: 1, 14 - 17, 22.01.2019

Taliha Karakök Sami Kınıklı Salih Cesur

https://doi.org/10.38053/agtd.495940

Öz

Günümüzde metisiline dirençli Staphylococcus
aureus ve vankomisine dirençli enterokoklar,penisiline dirençli pnömokoklar  gibi dirençli gram pozitif bakteriyel
enfeksiyonların tedavisi önemli bir sorundur. Dirençli gram pozitif bakteriyel
enfeksiyonların tedavisinde kullanılan linezolid oksazolidinon grubunda bir
antibiyotiktir. Etki mekanizması ribozom 50 S ünitesine bağlanarak protein
sentezini inisiasyon fazında inhibe eder. Bakteriostatik etkilidir. En önemli
yan etkisi 4 haftadan uzun süre ile kullanımda hematolojik yan etkilere
(trombositopeni ve anemi) neden olmasıdır. Bu yazıda linezolidin etki
spektrumu, endikasyonları ve yan etkileri özetlenmiştir. 

Anahtar Kelimeler

Linezolid, etki spektrumu, endikasyon, yan etkileri

Linezolide, a member of oxazolidinones group antibiotics which is used in resistant Gram positive infections

Öz

Management of infections
due to resistant gram positive microorganisms such as metisilin resistant Staphylococcus aureus, vancomycin
resistant enterococcus, penicillin resistant pneumococcus is a new challenge
for physicians by increasingly rates of antibiotic resistance. Linezolid which
is an agent used for the treatment of these resistant gram positive bacterial
infections is a member of oxazolidinones. The mechanism of action is involving inhibition of the
initiation of bacterial protein synthesis coupling ribosomal 50 S unit. It is
bacteriostatic against most bacteria. The most important adverse effect is
hematologic toxicity (thrombocytopenia and anemia) especially in longer usage
more than four weeks. Antimicrobial spectrum, clinical use and adverse effects
of linezolid is summarized in this review.

 

Anahtar Kelimeler

Linezolide, spectrum of antimicrobial activity, indication, side effects

Kaynakça

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