Diabetic cardiomyopathy in veterinary medicne

Öz

Diabetes mellitus (DM) is an important endocrine disorder in humans and animals, developing due to insulin deficiency or resistance to the effect of insulin, causing disturbances in carbohydrate, fat and protein metabolism, characterized by polyuria, polydipsia, polyphagia, weight loss, fatigue due to hyperglycemia, etc. clinical symptoms.In studies conducted on diabetic patients in the field of human medicine, the presence of ventricular dysfunction has been detected in patients who do not have a potential cause to predispose to coronary artery disease, hypertension and other cardiovascular diseases.The disorders caused by DM on the heart are expressed as diabetic cardiomyopathy (DCM).DCM is characterized by diastolic dysfunction, myocardial dilatation and decreased left ventricular function and is one of the important causes of morbidity and mortality in diabetic patients.Based on this prevalence result in human medicine, studies and researches on diabetic cardiomyopathy have been started in the field of veterinary medicine in recent years.The aim of this review is to provide information about DCM in cats and dogs, to examine and emphasize the relationship between diabetes mellitus and heart diseases, to increase the number of studies in this field and to draw attention to the need to add cardiac examination to routine controls in practice.

Anahtar Kelimeler

• diabetes
• cardiomyopathy
• heart
• veterinary medicine

Veteriner hekimlikte diyabetik kardiyomiyopati

Öz

Diabetes mellitus (DM) insanlarda ve hayvanlarda sık karşılaşılan, insülin eksikliğine veya insülinin etkisine gösterilen dirence bağlı olarak gelişen, karbonhidrat, yağ ve protein metabolizmalarında bozukluğa sebep olan, poliüri, polidipsi, polifaji, kilo kaybı, hiperglisemiye bağlı halsizlik vb. klinik semptomlarla karakterize önemli bir endokrin bozukluktur. Beşeri hekimlik alanında diyabetik hastalar üzerinde yapılan çalışmalarda koroner arter hastalığına, hipertansiyona ve diğer kardiyovasküler hastalıklara zemin hazırlayacak potansiyel bir nedeni olmayan hastalarda ventriküler disfonksiyon varlığı tespit edilmiştir.. DM’nin kalp üzerinde yaptığı bozukluklar diyabetik kardiyomiyopati (DKM) olarak ifade edilir. DKM, diyastolik disfonksiyon, miyokardiyal dilatasyon ve sol ventrikül fonksiyonlarında azalma ile karakterize olup diyabetik hastalarda morbidite ve mortalitenin önemli sebeplerindendir. Beşeri tıptaki bu prevalans sonucuna dayanarak son yıllarda veteriner hekimlik alanında da diyabetik kardiyomiyopatiyle ilgili çalışma ve araştırmalar yapılmaya başlanmıştır. Bu derlemenin amacı kedi ve köpeklerde DKM hakkında bilgi vermek, diabetes mellitus ile kalp hastalıkları arasındaki ilişkiyi irdelemek ve vurgulamak, bu alandaki çalışmaların arttrılmasına ve DM hastalarının kalp muayenesinin pratikte rutin kontrollere eklenmesi gerektiği konusuna dikkat çekmektir.

Anahtar Kelimeler

• diyabet
• kardiyomiyopati
• kalp
• veteriner hekimlik

Kaynakça

1. Al Hroob, A. M., Abukhalil, M. H., Hussein, O. E., & Mahmoud, A. M. (2019). Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallate. Biomedicine & Pharmacotherapy, 109, 2155-2172. https://doi.org/10.1016/j.biopha.2018.11.086
2. Aragno, M., Mastrocola, R., Alloatti, G., Vercellinatto, I., Bardini, P., Geuna, S., Catalano, M. G., Danni, O., & Boccuzzi, G. (2008). Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats. Endocrinology, 149 (1), 380-388. https://doi.org/10.1210/en.2007-0877
3. Boucher, J., Tseng, Y.H., & Kahn, C.R. (2010). Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. Journal of Biological Chemistry, 285(22), 17235- 17245. https://doi.org/10.1074/jbc.M110.118620
4. Broussard, J. L., Nelson, M. D., Kolka, C. M., Bediako, I. A., Paszkiewicz, R. L., Smith, L., Szczepaniak E.W., Stefanovski, D., Szczepaniak L.S., & Bergman, R. N. (2016). Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity. Diabetologia, 59(1), 197-207. https://doi.org/10.1007/s00125-015-3767-5
5. Çayır, A., & Turan, M. (2015). Diabetes mellitusla ilişkili kardiyak bozukluklar. Ankara Medical Journal, 15(4), 231-234 . https://doi.org/10.17098/amj.97668
6. Dobromylskyj, M. J., & Little, C. J. (2021). Necropsy findings in a cat with diabetes mellitus and heart failure. Journal of Feline Medicine and Surgery Open Reports, 7(2), 1-7. https://doi.org/10.1177/20551169211055383
7. Fall, T., Hamlin, H. H., Hedhammar, Å., Kämpe, O., & Egenvall, A. (2007). Diabetes mellitus in a population of 180,000 insured dogs: incidence, survival, and breed distribution. Journal of Veterinary Internal Medicine, 21(6), 1209-1216. https://doi.org/10.1111/j.1939-1676.2007.tb01940.x
8. Freeman, L.M., Rush, J.E., Cunningham, S.M., & Bulmer, B.J. (2014) A randomized study assessing the effect of diet in cats with hypertrophic cardiomyopathy. Journal of Veterinary Internal Medicine, 28, 847-856. https://doi.org/10.1111/jvim.12352

9. Kim, Y. H., Kim, J. H., & Park, C. (2018). Evaluation of tissue Doppler ultrasonographic and strain imaging for assessment of myocardial dysfunction in dogs with type 1 diabetes mellitus. American journal of veterinary research, 79(10), 1035-1043. https://doi.org/10.2460/ajvr.79.10.1035
10. Kitpipatkun, P., Matsuura, K., Shimada, K., Uemura, A., Goya, S., Yoshida, T., Ma., D., Takahashi, & K., Tanaka, R. (2020). Key factors of diastolic dysfunction and abnormal left ventricular relaxation in diabetic rats. Journal of Medical Ultrasonics, 47(3), 347-356. https://doi.org/10.1007/s10396-020-01021-x
11. Little, C. J. L., & Gettinby, G. (2008). Heart failure is common in diabetic cats: findings from a retrospective case‐controlled study in first‐opinion practice. Journal of Small Animal Practice, 49(1), 17-25. https://doi.org/10.1111/j.1748-5827.2007.00466.x
12. Miao, Y., Zhang, W., Zhong, Y., Zhong, M., & Ma, X. (2014). Diastolic function of the right ventricle is impaired in experimental type 2 diabetic rat models. Turkish journal of medical sciences, 44(3), 448-453. https://doi.org/10.3906/sag-1212-12
13. Mir, S. H., & Darzi, M. M. (2009). Histopathological abnormalities of prolonged alloxan‐induced diabetes mellitus in rabbits. International Journal of Experimental Pathology, 90(1), 66-73. https://doi.org/10.1111/j.1365-2613.2008.00615.x
14. Patil, M. B., & Burji, N.P. (2012). Echocardiographic evaluation of diastolic dysfunction in asymptomatic type 2 diabetes mellitus. J Assoc Physicians India, 60(23), 6.
15. Pereira, N. J., Matos, J. N., Toaldo, M. B., Bartoszuk, U., Summerfield, N., Riederer, A., & Glaus, T. M. (2017). Cats with diabetes mellitus have diastolic dysfunction in the absence of structural heart disease. The Veterinary Journal, 225, 50-55. https://doi.org/10.1016/j.tvjl.2017.04.017
16. Rand, J. S. (2013). Pathogenesis of feline diabetes. Veterinary Clinics: Small Animal Practice, 43(2), 221-231. https://doi.org/10.1016/j.cvsm.2013.01.003
17. Soares, F. A., Machado, L., Carvalho, G. L., González, F. H., & Poppl, Á. G. (2018). Cardiac troponin I, fructosamine, and cardiovascular parameters in dogs with diabetes mellitus. Austral journal of veterinary sciences, 50(3), 129-133. http://dx.doi.org/10.4067/S0719-81322018000300129
18. Şahinduran, Ş., & Vurkaç, N. (2018). Köpeklerde diabetes mellitus. Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 6(1), 43-50. https://doi.org/10.24998/maeusabed.329298
19. Türe, M., Balık, H., & Akın, A. (2019). Diyabetes Mellitus ve Kardiyovasküler Sistem. In: Haspolat YK., Aktar G., Kaya İ., Ege S. (Ed.) Çocuk ve Ergenlerde Diyabetes Mellitus (pp.143). Orient Yayınları.
20. Wilson, A. J., Gill, E. K., Abudalo, R. A., Edgar, K. S., Watson, C. J., & Grieve, D. J. (2018). Reactive oxygen species signalling in the diabetic heart: emerging prospect for therapeutic targeting. Heart, 104(4), 293-299. http://dx.doi.org/10.1136/heartjnl-2017-311448
21. Van den Brom, C.E., Bosmans,J.W., Vlasblom, R., Handoko, L.M., Huisman, M.C., Lubberink, M., Molthoff, C.F., Lammertsma, A.A., Ouwens, M.D., Diamant, M., & Boer, C. (2010). Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle. Cardiovasc Diabetol, 9, 25–31. https://doi.org/10.1186/1475-2840-9-25
22. Vichit, P., Rungsipipat, A., & Surachetpong, S. D. (2018). Changes of cardiac function in diabetic dogs. Journal of Veterinary Cardiology, 20(6), 438-450. https://doi.org/10.1016/j.jvc.2018.08.001
23. Yüce, İ., Tanboğa, İ.H., Bayraktutan, Ü., Aksakal, E.,Oğul, H., Yalçın, A., Kızrak, Y., & Kantarcı, A. (2013). Assessment of left-ventricular diastolic function in diabetic patients: the role of cardiac MR imaging. Turkish Journal of Medical Sciences, 43(1), 118-124. https://doi.org/10.3906/sag-1205-21
24. Zamora, M., & Villena, J. A. (2019). Contribution of impaired insulin signaling to the pathogenesis of diabetic cardiomyopathy. International Journal of Molecular Sciences, 20(11), 2833. https://doi.org/10.3390/ijms20112833