Araştırma Makalesi

An analysis of genetic transmission in a father and son with osteosarcoma

Cilt: 40 Sayı: 5 20 Ocak 2007
  • Fusun Tokatli
  • Fusun Tokatli
  • Rusen Cosar
  • Semsi Altaner
  • Funda Pala
  • Kazim Uygun
  • Cem Uzal
  • Erol Yalniz
Acta Orthopaedica et Traumatologica Turcica Kapak
Acta Orthopaedica et Traumatologica Turcica
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An analysis of genetic transmission in a father and son with osteosarcoma

Öz

Familial osteosarcoma is a rare hereditary disease. We present a 37-year-old father and a 17-year-old son who developed osteosarcoma in the left and right distal femurs, respectively, at a three-year interval. They were treated with chemotherapy followed by surgery. Both had positive immunostaining for p53 tumor suppressor gene and HER-2/neu oncogene. The son also exhibited deletion of the retinoblastoma 1 gene. Pulmonary metastasis was detected in the father at the time of diagnosis and 13 months after primary treatment, whereas no distant metastasis was present in the child. The father died 39 months after the diagnosis from primary symptoms, but the son led a disease-free survival a year after completion of treatment. Genetic abnormalities documented in the father and son corroborate the presence of specific genetic alterations in the pathogenesis of osteosarcoma.

Anahtar Kelimeler

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Fusun Tokatli Bu kişi benim

Fusun Tokatli Bu kişi benim

Rusen Cosar Bu kişi benim

Semsi Altaner Bu kişi benim

Funda Pala Bu kişi benim

Kazim Uygun Bu kişi benim

Erol Yalniz Bu kişi benim

Yayımlanma Tarihi

20 Ocak 2007

Gönderilme Tarihi

7 Mart 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2006 Cilt: 40 Sayı: 5

IZ

https://izlik.org/JA54RX73CJ

Kaynak Göster

RIS / Bibtex
APA
Tokatli, F., Tokatli, F., Cosar, R., Altaner, S., Pala, F., Uygun, K., Uzal, C., & Yalniz, E. (2007). An analysis of genetic transmission in a father and son with osteosarcoma. Acta Orthopaedica et Traumatologica Turcica, 40(5), 407-410. https://izlik.org/JA54RX73CJ
AMA
1.Tokatli F, Tokatli F, Cosar R, vd. An analysis of genetic transmission in a father and son with osteosarcoma. Acta Orthopaedica et Traumatologica Turcica. 2007;40(5):407-410. https://izlik.org/JA54RX73CJ
Chicago
Tokatli, Fusun, Fusun Tokatli, Rusen Cosar, vd. 2007. “An analysis of genetic transmission in a father and son with osteosarcoma”. Acta Orthopaedica et Traumatologica Turcica 40 (5): 407-10. https://izlik.org/JA54RX73CJ.
EndNote
Tokatli F, Tokatli F, Cosar R, Altaner S, Pala F, Uygun K, Uzal C, Yalniz E (01 Ocak 2007) An analysis of genetic transmission in a father and son with osteosarcoma. Acta Orthopaedica et Traumatologica Turcica 40 5 407–410.
IEEE
[1]F. Tokatli vd., “An analysis of genetic transmission in a father and son with osteosarcoma”, Acta Orthopaedica et Traumatologica Turcica, c. 40, sy 5, ss. 407–410, Oca. 2007, [çevrimiçi]. Erişim adresi: https://izlik.org/JA54RX73CJ
ISNAD
Tokatli, Fusun - Tokatli, Fusun - Cosar, Rusen - Altaner, Semsi - Pala, Funda - Uygun, Kazim - Uzal, Cem - Yalniz, Erol. “An analysis of genetic transmission in a father and son with osteosarcoma”. Acta Orthopaedica et Traumatologica Turcica 40/5 (01 Ocak 2007): 407-410. https://izlik.org/JA54RX73CJ.
JAMA
1.Tokatli F, Tokatli F, Cosar R, Altaner S, Pala F, Uygun K, Uzal C, Yalniz E. An analysis of genetic transmission in a father and son with osteosarcoma. Acta Orthopaedica et Traumatologica Turcica. 2007;40:407–410.
MLA
Tokatli, Fusun, vd. “An analysis of genetic transmission in a father and son with osteosarcoma”. Acta Orthopaedica et Traumatologica Turcica, c. 40, sy 5, Ocak 2007, ss. 407-10, https://izlik.org/JA54RX73CJ.
Vancouver
1.Fusun Tokatli, Fusun Tokatli, Rusen Cosar, Semsi Altaner, Funda Pala, Kazim Uygun, Cem Uzal, Erol Yalniz. An analysis of genetic transmission in a father and son with osteosarcoma. Acta Orthopaedica et Traumatologica Turcica [Internet]. 01 Ocak 2007;40(5):407-10. Erişim adresi: https://izlik.org/JA54RX73CJ