Araştırma Makalesi
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Dev hücreli kemik tümörü: Lokal nüks ile ilişkili olan cerrahi dışı faktörler

Yıl 2014, , 136 - 140, 18.04.2014
https://doi.org/10.3944/AOTT.2014.2714

Öz

Amaç: Bu çalışmanın amacı, dev hücreli tümör tanısı konulmuş hastalarda nüks oranını belirlemek ve nüks oranlarına etki eden faktörleri değerlendirmekti.

Çalışma planı: 2000–2009 döneminde dev hücreli tümör (DHT) tanısı konulan 41 hastaya (22 kadın, 19 erkek; yaş ortalaması 34.22±9.7) cerrahi ve adjuvan tedaviler uygulandı. Ortalama takip süresi 40.17±22.08 aydı. DHT’nin ortalama çapı 8.51±3.69 cm idi. Campanacci ve ark. tarafından geliştirilen sınıflandırmaya göre, 18 hastanın tümörü evre II; 23 hastanın evre III olarak sınıflandı. Lezyonun cerrahi sınırı, hastaların %60.9’unda intralezyonal rezeksiyon ve küretaj; %39.1’inde ise marjinal veya geniş rezeksiyondu.

Bulgular: 41 hastanın 9’unda (%22) tümörün tekrarlandığı görüldü. Lokal nüks ile cinsiyet (p=0.436), yaş (p=0.310), tümör lokalizasyonu (p=0.940), rezeksiyon genişliği (p=0.400) ve kullanılan dolgu materyeli tipi (PMMA veya otogreft) (p=0.680) arasında bir ilişki bulunmadı. Diğer taraftan lokal nüks ile Campanacci evre III sınıfında olma (p=0.028), ve tümörün büyüklüğü (p=0.034) arasında anlamlı bir ilişki saptandı.

Çıkarımlar: Sonuçlarımız Campanacci evrelemesinde III evrede olmanın ve tümör büyüklüğünün DHT rezeksiyonu sonrasında lokal nüks açısından risk faktörü olduğunu düşündürmektedir.

Kaynakça

  • Jaffe HL, Lichtenstein L, Portis RB. Giant cell tumor of bone: its pathologic appearance, grading, supposed variants, and treatment. Arch Pathol 1940;30:993-1031.
  • Prosser GH, Baloch KG, Tillman RM, Carter SR, Grimer RJ. Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone? Clin Orthop Relat Res 2005;435:211-8.
  • Dahlin DC. Caldwell Lecture. Giant cell tumor of bone: highlights of 407 cases. AJR Am J Roentgenol 1985;144:955-60.
  • Saiz P, Virkus W, Piasecki P, Templeton A, Shott S, Gitelis S. Results of giant cell tumor of bone treated with intralesional excision. Clin Orthop Relat Res 2004;424:221-6.
  • Capanna R, Fabbri N, Bettelli G. Curettage of giant cell tumor of bone. The effect of surgical technique and adjuvants on local recurrence rate. Chir Organi Mov 1990;75(1 Suppl):206.
  • Saglik Y, Yildiz Y, Karakas A, Ogüt H, Erekul S. Giant cell tumor of bone. Bull Hosp Jt Dis 1999;58:98-104.
  • O’Donnell RJ, Springfield DS, Motwani HK, Ready JE, Gebhardt MC, Mankin HJ. Recurrence of giant-cell tumors of the long bones after curettage and packing with cement. J Bone Joint Surg Am 1994;76:1827-33.
  • Turcotte RE, Wunder JS, Isler MH, Bell RS, Schachar N, Masri BA, et al. Giant cell tumor of long bone: a Canadian Sarcoma Group study. Clin Orthop Relat Res 2002;397:248-58.
  • Su YP, Chen WM, Chen TH. Giant-cell tumors of bone: an analysis of 87 cases. Int Orthop 2004;28:239-43.
  • Malawer MM, Bickels J, Meller I, Buch RG, Henshaw RM, Kollender Y. Cryosurgery in the treatment of giant cell tumor. A long-term followup study. Clin Orthop Relat Res 1999;359:176-88.
  • Zhen W, Yaotian H, Songjian L, Ge L, Qingliang W. Giant-cell tumour of bone. The long-term results of treatment by curettage and bone graft. J Bone Joint Surg Br 2004;86:212-6.
  • Ghert MA, Rizzo M, Harrelson JM, Scully SP. Giant-cell tumor of the appendicular skeleton. Clin Orthop Relat Res 2002;400:201-10.
  • Ward WG Sr, Li G 3rd. Customized treatment algorithm for giant cell tumor of bone: report of a series. Clin Orthop Relat Res 2002;397:259-70.
  • Jones KB, DeYoung BR, Morcuende JA, Buckwalter JA. Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J 2006;26:69-76.
  • Masui F, Ushigome S, Fujii K. Giant cell tumor of bone: a clinicopathologic study of prognostic factors. Pathol Int 1998;48:723-9.
  • Campanacci M. Giant cell tumor. In: Campanacci M, editor. Bone and soft tissue tumors. 2nd ed. New York: Springer-Verlag; 1999. p. 99-142.

Giant cell tumors of bone: nonsurgical factors associated with local recurrence

Yıl 2014, , 136 - 140, 18.04.2014
https://doi.org/10.3944/AOTT.2014.2714

Öz

Objective: To determine the rate of giant cell tumor (GCT) recurrence and evaluate the factors associated with its recurrence in patients who underwent surgery and submitted to only one adjuvant method.

Methods: Forty–one patients (22 female, 19 male; mean age: 34.22±9.70 years) with GCT, who underwent surgical and one adjuvant treatment, were evaluated after a mean follow-up period of 40.17±22.08 months. The average tumor size was 8.51 ± 3.69 cm. The tumors in 18 patients (43.9%) were grade II and in 23 patients (56.1%) grade III, according to the system developed by Campanacci et al. The surgical margin was intralesional resection and curettage in 60.9% of the patients, and marginal or wide resection in 39.1%.

Results: Nine (22%) of the 41 patients had recurrence. None of the gender (p=0.436), age (p=0.310), site of the tumor (p=0.940), surgical margins (p=0.400) and the type of the filling material (PMMA or autograft) (p=0.680) had an association with recurrence. However, Campanacci grade III (p=0.028) and the size of the tumor (p=0.034) was associated with the recurrence.

Conclusion: Tumor size and tumor grade III according to the Campanacci system appear to be risk factors for local recurrence after the local resection of GCT.

Kaynakça

  • Jaffe HL, Lichtenstein L, Portis RB. Giant cell tumor of bone: its pathologic appearance, grading, supposed variants, and treatment. Arch Pathol 1940;30:993-1031.
  • Prosser GH, Baloch KG, Tillman RM, Carter SR, Grimer RJ. Does curettage without adjuvant therapy provide low recurrence rates in giant-cell tumors of bone? Clin Orthop Relat Res 2005;435:211-8.
  • Dahlin DC. Caldwell Lecture. Giant cell tumor of bone: highlights of 407 cases. AJR Am J Roentgenol 1985;144:955-60.
  • Saiz P, Virkus W, Piasecki P, Templeton A, Shott S, Gitelis S. Results of giant cell tumor of bone treated with intralesional excision. Clin Orthop Relat Res 2004;424:221-6.
  • Capanna R, Fabbri N, Bettelli G. Curettage of giant cell tumor of bone. The effect of surgical technique and adjuvants on local recurrence rate. Chir Organi Mov 1990;75(1 Suppl):206.
  • Saglik Y, Yildiz Y, Karakas A, Ogüt H, Erekul S. Giant cell tumor of bone. Bull Hosp Jt Dis 1999;58:98-104.
  • O’Donnell RJ, Springfield DS, Motwani HK, Ready JE, Gebhardt MC, Mankin HJ. Recurrence of giant-cell tumors of the long bones after curettage and packing with cement. J Bone Joint Surg Am 1994;76:1827-33.
  • Turcotte RE, Wunder JS, Isler MH, Bell RS, Schachar N, Masri BA, et al. Giant cell tumor of long bone: a Canadian Sarcoma Group study. Clin Orthop Relat Res 2002;397:248-58.
  • Su YP, Chen WM, Chen TH. Giant-cell tumors of bone: an analysis of 87 cases. Int Orthop 2004;28:239-43.
  • Malawer MM, Bickels J, Meller I, Buch RG, Henshaw RM, Kollender Y. Cryosurgery in the treatment of giant cell tumor. A long-term followup study. Clin Orthop Relat Res 1999;359:176-88.
  • Zhen W, Yaotian H, Songjian L, Ge L, Qingliang W. Giant-cell tumour of bone. The long-term results of treatment by curettage and bone graft. J Bone Joint Surg Br 2004;86:212-6.
  • Ghert MA, Rizzo M, Harrelson JM, Scully SP. Giant-cell tumor of the appendicular skeleton. Clin Orthop Relat Res 2002;400:201-10.
  • Ward WG Sr, Li G 3rd. Customized treatment algorithm for giant cell tumor of bone: report of a series. Clin Orthop Relat Res 2002;397:259-70.
  • Jones KB, DeYoung BR, Morcuende JA, Buckwalter JA. Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J 2006;26:69-76.
  • Masui F, Ushigome S, Fujii K. Giant cell tumor of bone: a clinicopathologic study of prognostic factors. Pathol Int 1998;48:723-9.
  • Campanacci M. Giant cell tumor. In: Campanacci M, editor. Bone and soft tissue tumors. 2nd ed. New York: Springer-Verlag; 1999. p. 99-142.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orijinal Makale
Yazarlar

Luiz Eduardo Moreira Teixeira Bu kişi benim

José Carlos Souza Vilela Bu kişi benim

Ricardo Horta Miranda Bu kişi benim

Anderson Humberto Gomes Bu kişi benim

Frederico Alves Costa Bu kişi benim

Vinicius Carvalho De Faria Bu kişi benim

Yayımlanma Tarihi 18 Nisan 2014
Yayımlandığı Sayı Yıl 2014

Kaynak Göster

APA Moreira Teixeira, L. E., Souza Vilela, J. C., Horta Miranda, R., Gomes, A. H., vd. (2014). Giant cell tumors of bone: nonsurgical factors associated with local recurrence. Acta Orthopaedica Et Traumatologica Turcica, 48(2), 136-140. https://doi.org/10.3944/AOTT.2014.2714
AMA Moreira Teixeira LE, Souza Vilela JC, Horta Miranda R, Gomes AH, Alves Costa F, De Faria VC. Giant cell tumors of bone: nonsurgical factors associated with local recurrence. Acta Orthopaedica et Traumatologica Turcica. Nisan 2014;48(2):136-140. doi:10.3944/AOTT.2014.2714
Chicago Moreira Teixeira, Luiz Eduardo, José Carlos Souza Vilela, Ricardo Horta Miranda, Anderson Humberto Gomes, Frederico Alves Costa, ve Vinicius Carvalho De Faria. “Giant Cell Tumors of Bone: Nonsurgical Factors Associated With Local Recurrence”. Acta Orthopaedica Et Traumatologica Turcica 48, sy. 2 (Nisan 2014): 136-40. https://doi.org/10.3944/AOTT.2014.2714.
EndNote Moreira Teixeira LE, Souza Vilela JC, Horta Miranda R, Gomes AH, Alves Costa F, De Faria VC (01 Nisan 2014) Giant cell tumors of bone: nonsurgical factors associated with local recurrence. Acta Orthopaedica et Traumatologica Turcica 48 2 136–140.
IEEE L. E. Moreira Teixeira, J. C. Souza Vilela, R. Horta Miranda, A. H. Gomes, F. Alves Costa, ve V. C. De Faria, “Giant cell tumors of bone: nonsurgical factors associated with local recurrence”, Acta Orthopaedica et Traumatologica Turcica, c. 48, sy. 2, ss. 136–140, 2014, doi: 10.3944/AOTT.2014.2714.
ISNAD Moreira Teixeira, Luiz Eduardo vd. “Giant Cell Tumors of Bone: Nonsurgical Factors Associated With Local Recurrence”. Acta Orthopaedica et Traumatologica Turcica 48/2 (Nisan 2014), 136-140. https://doi.org/10.3944/AOTT.2014.2714.
JAMA Moreira Teixeira LE, Souza Vilela JC, Horta Miranda R, Gomes AH, Alves Costa F, De Faria VC. Giant cell tumors of bone: nonsurgical factors associated with local recurrence. Acta Orthopaedica et Traumatologica Turcica. 2014;48:136–140.
MLA Moreira Teixeira, Luiz Eduardo vd. “Giant Cell Tumors of Bone: Nonsurgical Factors Associated With Local Recurrence”. Acta Orthopaedica Et Traumatologica Turcica, c. 48, sy. 2, 2014, ss. 136-40, doi:10.3944/AOTT.2014.2714.
Vancouver Moreira Teixeira LE, Souza Vilela JC, Horta Miranda R, Gomes AH, Alves Costa F, De Faria VC. Giant cell tumors of bone: nonsurgical factors associated with local recurrence. Acta Orthopaedica et Traumatologica Turcica. 2014;48(2):136-40.