Teikoplanin ve siprofloksasin katkılı kemik çimentosunun 1. ve 15. Günlerde mekanik dayanıklılığının karşılaştırılması

Öz

Amaç:Bu çalışmanın amacı kemik çimentolarına değişik konsantrasyonlarda teikoplanin ve siprofloksasin katılmasının mekanik etkilerinin karşılaştırılması idi.

Çalışma planı: Deneysel bir modelde, teikoplanin ve siprofloksasinin üç farklı dozu (800, 1600 ve 3200 mg) kemik çimentosuna eklendi. Kompresyon ve dört nokta eğme testinin bulunduğu mekanik testler 1. gün ve antibiyotiğin 37°C suda filtrelendiği 15. günde uygulandı. Hiç antibiyotik içermeyen örnekler kontrol grubu olarak kabul edildi. Her antibiyotik konsantrasyonunun 1. ve 15. gündeki mekanik dayanıklılıkları değerlendirildi.

Bulgular: Hem teikoplanin hem de siprofloksasinin, kompresyon ve dört nokta eğme testlerindeki ortalama dayanıklılık değerlerini 1. ve 15. günde anlamlı derecede azalttığı gözlendi (p<0.05). Teikoplanin ortalama dayanım değerleri 1. ve 15. günde yüksek dozlarda her iki testte azalırken (p<0.05), siprofloksasin dayanım değerleri bu dozlarda anlamlı olarak değişmedi. İki ilacın etkileri karşılaştırıldığında, 1. günde 3200 mg grubu ve 15. günde 1600 ve 3200 mg gruplarındaki kompresyon testi değerlerinde ve 15. günde 3200 mg grubundaki dört nokta eğme testi değerlerinde anlamlı farklılıklar vardı.

Çıkarımlar: Teikoplanin ve siprofloksasin katılan kemik çimentosunun biyomekanik özellikleri zayıflamaktadır. Sonuçlarımıza göre, teikoplanine kıyasla siprofloksasinin dayanıklılık üzerindeki negatif etkisi daha kısıtlıdır.

Anahtar Kelimeler

• Kemik çimentosu; kırılma noktası; siprofloksasin; teikoplanin

Investigation of mechanical strength of teicoplanin and ciprofloxacin impregnated bone cement on Day 1 and Day 15

Öz

Objective:The aim of this study was to compare the mechanical effects of different concentrations of teicoplanin and ciprofloxacin addition in bone cement.

Methods: In an experimental design, 3 different doses of teicoplanin and ciprofloxacin (800, 1600 and 3200 mg) were added to bone cement. Mechanical tests using compression and four-point bending tests were performed on Day 1 and after antibiotic leaching in water at 37°C on Day 15. Specimens that contained no antibiotics served as controls. Mechanical strength for each antibiotic concentration on Day 1 and Day 15 were evaluated.

Results: Both teicoplanin and ciprofloxacin significantly decreased the mean strength values in compression and four-point bending tests at Days 1 and 15 (p<0.05). While teicoplanin significantly decreased the mean strength values at high doses in both tests at Days 1 and 15 (p<0.05), ciprofloxacin did not significantly change these values. When the effects of two drugs compared, there were significant differences at the 3200 mg dose at Day 1 and at 1600 and 3200 mg doses at Day 15 in the compression testing and at 3200 mg at Day 15 in the four-point bending test.

Conclusion: Teicoplanin and ciprofloxacin addition may adversely affect the biomechanical strength of bone cement. Ciprofloxacin addition seems to have less of a negative effect on strength than teicoplanin.

Anahtar Kelimeler

• Bone cement
• ciprofloxacin
• fracture point
• teicoplanin

Kaynakça

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