INVESTIGATION OF THE ANTI-CANCER PROPERTIES OF BEE VENOM AND MELLITIN PEPTIDE

Yıl 2024, Cilt: 3 Sayı: 1, 1 - 16, 27.06.2024

Yahya Yasin Yılmaz

Öz

Mellitin (MEL) and thus bee venom (BV) are potential animal drug source candidates for cancer treatment. In various cell culture and animal model studies, MEL has anti-cancer properties such as cytotoxicity, hemolytic activity, and growth inhibition. However, this peptide is not yet suitable for human use due to its specific cytotoxic protection. However, various appropriate transportation systems are being used to resolve the problems. With this study, we present information about the anti-cancer properties of bee venom and MEL, the studies carried out and the current perspective, and their possible effect systems.

Anahtar Kelimeler

Melittin, Bee Venom, Anticancer drug, Biotechnology, Biochemistry

ARI ZEHRİ VE MELLİTİN PEPTİDİNİN ANTİKANSER ÖZELLİKLERİNİN İNCELENMESİ

Öz

Mellitin (MEL) ve dolayısıyla arı zehri (BV) kanser tedavisinde kullanılmaya aday önemli hayvansal ilaç kaynağı potansiyelidir. Çeşitli hücre kültürü ve hayvan modeli çalışmalarında anti-kanser özellikler gösteren MEL, sitotoksisite, hemolitik aktivite ve büyüme inhibisyonu gibi etkilere sahiptir. Bunun yanında bu peptid spesifik sitotoksik olmadığından dolayı insan kullanımına henüz uygun değildir. Fakat sorunları alt etmek için çeşitli uygun transport sistemler üzerinde optimizasyon çalışmaları yürütülmektedir. Bu çalışma ile arı zehri ve MEL’in anti-kanser özelliklerine dair yapılan çalışmalara ve mevcut bakış açısına işaret ederek olası etki sistemlerine dair bilgiler sunmaktayız.

Anahtar Kelimeler

Mellitin, Arı Zehri, Anti-kanser ilaç, Biyoteknoloji, Biyokimya

Kaynakça

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