SPR biosensor applications for the detection of pathogenic microorganisms in the field of food safety and health

Yıl 2021, Cilt: 4 Sayı: 2, 50 - 63, 30.12.2021

Kardelen Cemek Betül Ünal Okan Zenger Gözde Baydemir Peşint

Öz

Detection and quantification of pathogens has become a key point, especially in the food safety and health
applications. Since traditional methods such as ELISA and PCR used for the detection and analysis of these
microorganisms usually involve advanced culture techniques and various biochemical analyzes which are timeconsuming,
it is very important to produce materials that can detect pathogens quickly and sensitively as an
alternative to traditional methods. Surface Plasmon Resonance (SPR), one of the advanced sensor technologies, is
an optical method used to measure changes in the refractive index on a sensor surface to characterize
macromolecular interactions, and it is being used more and more in the label-free detection of microorganisms.
SPR technology has several advantages with its sensitive and effective results that allow the simultaneous detection
of different targets in a very short time. In this review, the use of SPR-based sensors and current studies for the
detection of pathogenic microorganisms in food safety and health applications are summarized.

Anahtar Kelimeler

Food safety, Medical diagnosis, Pathogenic microorganisms, Surface plasmon resonance sensors

Gıda güvenliği ve sağlık alanında patojen mikroorganizmaların tespitine yönelik SPR biyosensör uygulamaları

Öz

Patojenlerin tespiti ve miktar analizi, özellikle gıda güvenliği ve sağlık uygulamalarında kilit nokta haline
gelmiştir. Bu mikroorganizmaların tespiti ve analizi için kullanılan ELISA ve PCR gibi geleneksel yöntemler
genellikle ileri kültür yöntemleri ve uzun zaman alan çeşitli biyokimyasal analizleri içerdiğinden, geleneksel
yöntemlere alternatif olarak hızlı ve hassas bir şekilde patojenleri tespit edebilen malzemelerin üretilmesi oldukça
önemlidir. İleri sensör teknolojilerinden biri olan yüzey plazmon rezonans (SPR), makromoleküler etkileşimleri
karakterize etmek amacıyla bir sensör yüzeyinde meydana gelen kırılma indisi değişikliklerini ölçmek için
kullanılan optik bir yöntemdir ve mikroorganizmaların etiketsiz tespiti için bu yöntemden her geçen gün daha fazla
yararlanılmaktadır. Oldukça kısa sürede, farklı hedeflerin aynı anda algılanmasına dahi izin veren hassas ve etkili
sonuçlarıyla SPR teknolojisi çeşitli avantajlara sahiptir. Bu derlemede gıda güvenliği ve sağlık uygulamalarında
patojen mikroorganizmaların tespiti için SPR biyosensörlerin kullanımı ve mevcut çalışmalar özetlenmiştir.

Anahtar Kelimeler

Gıda güvenliği, Patojen mikroorganizmalar, Tıbbi tanı, Yüzey plazmon rezonans sensörleri

Kaynakça

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