L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri

Aslı Koç; Arzu Zeynep Karabay; Tülin Özkan; Zeliha Büyükbingöl; Asuman Sunguroğlu; Fügen Aktan

doi:10.1501/Ashd_0000000114

EN TR

Öz

It is an effective antioxidant molecule that exhibits free radical scavenging activity and it enhances antioxidant status in rats and exhibited anticancer properties. It has been shown that α-Lipoic acid is a very effective molecule against type 2 diabetes, atherosclerosis, inflammatory skin diseases, reperfusion arrhythmias and Parkinson’s disease and serves apoptotic action in different cancer cells. These molecules can display important roles in treatment of colon cancer. In this study, we examined the synergetic effects of α-lipoic acid and L-carnitine on HCT 116 +/+ and HCT 116 -/- colon cancer cell line. For this purpose, HCT 116 +/+ and -/- colon cancer cells were treated with L-carnitine and α-Lipoic acid for 24 hours and MTT assay and caspase 3 enzyme activity assay was conducted. α -Lipoic acid and L-carnitine alone or in combination decreased cell viability in HCT 116 +/+ and /- colon cancer cells and exhibited synergetic effect on the cell viability. Further studies must be conducted to find out the mechanism of their effects in cancer therapy

Anahtar Kelimeler

L-carnitine, α-lipoic acid, colon cancer

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Aslı Koç Bu kişi benim

Arzu Zeynep Karabay Bu kişi benim

Tülin Özkan Bu kişi benim

Zeliha Büyükbingöl Bu kişi benim

Asuman Sunguroğlu Bu kişi benim

Fügen Aktan Bu kişi benim

Yayımlanma Tarihi

24 Haziran 2016

Gönderilme Tarihi

1 Ekim 2016

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2016 Cilt: 15 Sayı: 2

DOI

https://doi.org/10.1501/Ashd_0000000114

IZ

https://izlik.org/JA65CE69PG

APA

Koç, A., Karabay, A. Z., Özkan, T., Büyükbingöl, Z., Sunguroğlu, A., & Aktan, F. (2016). L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri. Ankara Sağlık Hizmetleri Dergisi, 15(2), 1-8. https://doi.org/10.1501/Ashd_0000000114

AMA

1.Koç A, Karabay AZ, Özkan T, Büyükbingöl Z, Sunguroğlu A, Aktan F. L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri. ASHD. 2016;15(2):1-8. doi:10.1501/Ashd_0000000114

Chicago

Koç, Aslı, Arzu Zeynep Karabay, Tülin Özkan, Zeliha Büyükbingöl, Asuman Sunguroğlu, ve Fügen Aktan. 2016. “L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri”. Ankara Sağlık Hizmetleri Dergisi 15 (2): 1-8. https://doi.org/10.1501/Ashd_0000000114.

EndNote

Koç A, Karabay AZ, Özkan T, Büyükbingöl Z, Sunguroğlu A, Aktan F (01 Haziran 2016) L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri. Ankara Sağlık Hizmetleri Dergisi 15 2 1–8.

IEEE

[1]A. Koç, A. Z. Karabay, T. Özkan, Z. Büyükbingöl, A. Sunguroğlu, ve F. Aktan, “L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri”, ASHD, c. 15, sy 2, ss. 1–8, Haz. 2016, doi: 10.1501/Ashd_0000000114.

ISNAD

Koç, Aslı - Karabay, Arzu Zeynep - Özkan, Tülin - Büyükbingöl, Zeliha - Sunguroğlu, Asuman - Aktan, Fügen. “L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri”. Ankara Sağlık Hizmetleri Dergisi 15/2 (01 Haziran 2016): 1-8. https://doi.org/10.1501/Ashd_0000000114.

JAMA

1.Koç A, Karabay AZ, Özkan T, Büyükbingöl Z, Sunguroğlu A, Aktan F. L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri. ASHD. 2016;15:1–8.

MLA

Koç, Aslı, vd. “L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri”. Ankara Sağlık Hizmetleri Dergisi, c. 15, sy 2, Haziran 2016, ss. 1-8, doi:10.1501/Ashd_0000000114.

Vancouver

1.Aslı Koç, Arzu Zeynep Karabay, Tülin Özkan, Zeliha Büyükbingöl, Asuman Sunguroğlu, Fügen Aktan. L-Karnitin ve Alfa-Lipoik Asitin, HCT 116 +/+ ve -/- Kolon Kanser Hücre Serilerinin Proliferasyonu Üzerindeki Sinerjetik Etkileri. ASHD. 01 Haziran 2016;15(2):1-8. doi:10.1501/Ashd_0000000114

Öz

Anahtar Kelimeler