Kritik COVID-19 hastalarında kullanılan N-asetilsisteinin(NAC) klinik bulgulara, inflamatuar parametrelere böbrek fonksiyonlarına olan etkileri

Öz

Amaç: Bu çalışmada N-asetilsistein (NAC)’in COVID-19 nedeniyle üçüncü basamak yoğun bakım ihtiyacı olan kritik hastalarda; klinik bulgulara, inflamatuar parametrelere, böbrek fonksiyonlarına olan etkileri araştırıldı. Materyal ve Metod: Bu tek merkezli retrospektif çalışmaya, Nisan- Eylül 2020 tarihleri arasında COVİD-19 PCR pozitifliği doğrulanmış 190 yetişkin hasta dahil edildi. Standart tedaviye ek olarak NAC (2400mg/gün dozda intravenöz olarak günde 1 defa) alan hastalar ile tek başına standart tedavi verilen hastaların klinik ve laboratuar bulguları karşılaştırıldı. Bulgular: Gruplar arasında yaş (p=0.423), cinsiyet (p=0.086), entübasyon (p=0,196), ölüm (p=0,387), hastane yatış (p=0,085) ve yoğun bakım yatış gün sayısı (p=0.584) açısından fark saptanmadı. Birinci gün, üçüncü gün, yedinci gün, onuncu gün ve onbeşinci gün bakılan CRP (C-reactive protein), ferritin, fibrinojen, nötrofil, lenfosit sayısı, D-dimer, kreatinin değerlerinde NAC alan ve almayanlar arasında anlamlı bir fark saptanmadı (p>0.05). Sonuç: COVID-19 nedeniyle 3. Basamak yoğun bakım yatışı olan hastalarda NAC tedavisi ölümü, hastane yatış ve yoğun bakım yatış gün sayısını etkilememiştir. Aynı zamanda inflamatuar parametrelere böbrek fonksiyonlarına olumlu veya olumsuz bir etki göstermemiştir.

Anahtar Kelimeler

• COVID-19
• N-asetilsistein
• yoğun bakım

The effects of N-acetylcysteine (NAC) used in critical COVID-19 patients on clinical findings, inflammatory parameters and kidney functions

Öz

Objective: In this study, N-acetylcysteine (NAC) was used in critically ill patients who needed tertiary care due to COVID-19; The effects on clinical findings, inflammatory parameters and kidney functions were investigated. Materials and Methods: 190 adult patients with confirmed COVID-19 PCR positivity between April and September 2020 were included in this single-center retrospective study. The clinical and laboratory findings of the patients who received NAC (2400mg/day intravenously once a day) in addition to the standard treatment and the patients who were given the standard treatment alone were compared. Results: Age (p=0.423), gender (p=0.086), intubation (p=0.196), death (p=0.387), hospitalization (p=0.085), and intensive care unit stay (p=0.584) between groups There was no difference in terms of No significant difference was found between those who took NAC and those who did not, in the values of CRP (C-reactive protein), ferritin, fibrinogen, neutrophil, lymphocyte count, D-dimer, and creatinine measured on the first day, third day, seventh day, tenth day and fifteenth day (p> 0.05). Conclusion: NAC treatment did not affect the number of deaths, hospitalization and intensive care hospitalization days in patients admitted to the 3rd line intensive care unit due to COVID-19. At the same time, it did not show a positive or negative effect on inflammatory parameters and kidney functions.

Anahtar Kelimeler

• COVID-19
• N-acetylcysteine
• intensive care

Kaynakça

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