Statin kullanımına bağlı pankreatik enzim yükselmesi-vaka sunumu

Öz

Statin kullanımıyla birlikte kas ağrıları, karaciğer enzim yüksekliği ve rabdomyoliz görülebilmektedir. Pankreas hasarı ve buna bağlı lipaz yüksekliği statinin nadir görülen ciddi istenmeyen etkilerindendir. Bu vaka sunumunda, statin kullanımından sonra lipaz seviyelerinde yükselme görülen, serebrovasküler hastalık ve prostat kanseri öyküsü bulunan 61 yaşında bir erkek hastayı değerlendirdik. Bu hastada olası pankreatik hasar görülen hastada farklı statin gruplarını denedik ve statin kullanımına bağlı olası pankreas hasar mekanizmalarını ele aldık.

Anahtar Kelimeler

• pankreas
• lipaz
• statin

A case of pancreatic enzyme elevation due to use of statins

Öz

It is well known that statin usage is linked with side effects such as miyalgias, hepatic enzyme elevation and rabdomyolisis. Pancreatic injury and lipase elevation may be a rare side effect of statins. In this case report, we present a 61-year-old male with the history of cerebrovascular disease (CVD) and prostate cancer which experienced elevation of lipase levels after use of statins. We tried different types of statins for the patients condition of pancreatic injury and in this case report, the possible reasons of statin induced pancreatic injury are underlined.

Anahtar Kelimeler

• pancreas
• statin
• lipase

Kaynakça

1. 1. Jaya Krishna Chintanaboina and Deepa Gopavaram, Recurrent Acute Pancreatitis Probably Induced by Rosuvastatin Therapy: A Case Report Hindawi Publishing Corporation Case Reports in Medicine Volume 2012, Article ID 973279, 4 pages.
2. 2. G.Miltiades, A.Anthopoulos & M.Elisaf (2003), Acute pancreatitis possibly associated with combined salicylate and atorvastatin therapy: JOP. J Pancreas (Online) 4(1):20-21.
3. 3. S.Singh,A.Nautiyal,andJ.G.Dolan,Recurrentacute pancreatitis possibly induced by atorvastatin and rosuvastatin. Is statin-induced pancreatit is a class effect? JOP. J Pancreas (Online) 2004; 5(6):502-504.
4. 4. J.L.Johnson and I.B.Loomis, A case of simvastatin-associated pancreatitis and review of statin-associated pancreatitis, Pharmacotherapy 2006;26(3):414–422.
5. 5. Deshpande PR, Khera K, Thunga G, Hande M, Gouda ST, Nagappa AN. Atorvastatin-induced acute pancreatitis. J Pharmacol Pharmaco ther. 2011;2(1):40–42.
6. 6. Nison Badalov et al. Drug-Induced Acute Pancreatitis: An Evidence-Based Review: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2007;5:648–661.
7. 7. Jun Gong et al. Statins and pancreatic cancer (Review): ONCOLOGY LETTERS 13: 1035-1040, 2017.