The Importance of Autophagy Mechanism as a Novel Therapeutic Target in SARS-CoV-2

Yıl 2021, Cilt: 2 Sayı: 3, 30 - 33, 31.12.2021

Sevide Şencan

Öz

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global pandemic and major public health issue, called the disease as coronavirus disease-2019 (COVID-19). It spreads rapidly from an infected person via respiratory droplets by breathing, sneezing, coughing. The symptoms of COVID-19 are dry cough, fever, fatigue, shortness of breath, pneumonia. The epidemiological and pathological features of SARS-CoV-2 are still unclear and requires further investigation. In previous studies, coronaviruses have been shown to use the endocytic pathway and autophagy mechanism to enter and replicate into the host cells. In this mini-review, we will focus on the role of autophagy mechanism in SARS-CoV-2 infection and therapeutic potential of this pathway.

Anahtar Kelimeler

SARS-CoV-2, COVID-19, Coronavirus, Autophagy

Kaynakça

• 1. Weiss SR and Navas-Martin S (2005) Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev 69:635-64. doi: 10.1128/mmbr.69.4.635-664.2005
• 2. de Haan CA and Rottier PJ (2005) Molecular interactions in the assembly of coronaviruses. Adv Virus Res 64:165-230. doi: 10.1016/S0065-3527(05)64006-7
• 3. Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y and Zuo W (2020) Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2. Am J Respir Crit Care Med 202:756-759. doi: 10.1164/rccm.202001-0179LE
• 4. Danilczyk U and Penninger JM (2006) Angiotensin-converting enzyme II in the heart and the kidney. Circ Res 98:463-71. doi: 10.1161/01.RES.0000205761.22353.5f