Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler

Gökmen Arabacı; Sumeray Ayan; Fatma Gündüz; Yasemin İspirli Doğaç

Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler

Öz

Nanoteknoloji, tıp bilimleri dahil olmak üzere hayatın hemen her alanında önemli bir rol oynamıştır. Nanoteknolojik ürünlerin önemli bir sınıfını da nanofiberler oluşturmaktadır. Nanofiberlerle biyomedikal uygulamalarla ilgili başlıca araştırma hatları, kontrollü ilaç salım uygulamaları için antitümör ilaçların kapsüllenmesini, doku mühendisliği ve rejeneratif tıp için iskele yapılarını ve ayrıca kanser tümörlerinin azaltılmasında uygulanacak manyetik veya plazmonik hipertermiyi kapsamaktadır. Özellikle, kemoterapide kullanılan genel antikanser ilaçlarının, yüksek doz kullanımları ile ciddi yan etkilerle ilişkili olması ve normal hücrelere de zarar vermesinden dolayı, kontrollü ve sürekli bir ilaç salınımı, faydalar sağlamaktadır. Bu amaçla kullanılan antikanser ilacı yüklü nanofiberler, ilacın daha uzun süre korunmasını ve daha az ilaçla sonuca ulaşılmasını sağladığı için önemli sonuçlara ulaşılmıştır. Elektrospun nanofiberler, çok geniş yüzey alanına, kontrol edilebilir gözenek boyutuna ve ayarlanabilir ilaç salım profillerine sahip olup, gelecek vadeden adaylardır. Elektroeğirme yönteminin nanofiber yapıları üretmede sunduğu göreceli kolaylık, farklı polimer yapıların, polimer veya inorganik maddelerin kompozit olarak kullanılabilmeleri, farklı boyut, şekil, gözenek boyutlarında üretilebilmeleri, dış ve/veya iç uyaranlara (pH, sıcaklık, manyetik alan, ışık vb.) yanıt verme yeteneklerine sahip olabilmeleri, yeni stratejilerin ve yeni araştırmaların sayısını oldukça arttırmaktadır. Bunun yanında, nanofiberlerin kanser tedavisinde uygulanmasına ilişkin çok sayıda araştırma raporu bulunmaktadır. Bu derleme makale, başarılı kanser tedavisi için rapor edilmiş, bazı elektrospun nanofiberlere genel bir yaklaşımla odaklanmaktadır.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Gökmen Arabacı
0000-0002-5848-6117
Türkiye

Sumeray Ayan
Türkiye

Fatma Gündüz
0000-0002-2642-8916
Türkiye

Yasemin İspirli Doğaç ^*
0000-0001-8616-0280
Türkiye

Yayımlanma Tarihi

21 Kasım 2023

Gönderilme Tarihi

3 Mayıs 2023

Kabul Tarihi

13 Kasım 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 3 Sayı: 2

IZ

https://izlik.org/JA88ES42DS

Kaynak Göster

RIS / Bibtex

APA

Arabacı, G., Ayan, S., Gündüz, F., & İspirli Doğaç, Y. (2023). Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. Ata-Kimya Dergisi, 3(2), 39-55. https://izlik.org/JA88ES42DS

AMA

1.Arabacı G, Ayan S, Gündüz F, İspirli Doğaç Y. Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. J Ata-Chem. 2023;3(2):39-55. https://izlik.org/JA88ES42DS

Chicago

Arabacı, Gökmen, Sumeray Ayan, Fatma Gündüz, ve Yasemin İspirli Doğaç. 2023. “Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler”. Ata-Kimya Dergisi 3 (2): 39-55. https://izlik.org/JA88ES42DS.

EndNote

Arabacı G, Ayan S, Gündüz F, İspirli Doğaç Y (01 Kasım 2023) Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. Ata-Kimya Dergisi 3 2 39–55.

IEEE

[1]G. Arabacı, S. Ayan, F. Gündüz, ve Y. İspirli Doğaç, “Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler”, J Ata-Chem, c. 3, sy 2, ss. 39–55, Kas. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA88ES42DS

ISNAD

Arabacı, Gökmen - Ayan, Sumeray - Gündüz, Fatma - İspirli Doğaç, Yasemin. “Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler”. Ata-Kimya Dergisi 3/2 (01 Kasım 2023): 39-55. https://izlik.org/JA88ES42DS.

JAMA

1.Arabacı G, Ayan S, Gündüz F, İspirli Doğaç Y. Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. J Ata-Chem. 2023;3:39–55.

MLA

Arabacı, Gökmen, vd. “Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler”. Ata-Kimya Dergisi, c. 3, sy 2, Kasım 2023, ss. 39-55, https://izlik.org/JA88ES42DS.

Vancouver

1.Gökmen Arabacı, Sumeray Ayan, Fatma Gündüz, Yasemin İspirli Doğaç. Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler. J Ata-Chem [Internet]. 01 Kasım 2023;3(2):39-55. Erişim adresi: https://izlik.org/JA88ES42DS