Syntheses of Bromocyclitos via Cyclohexene and Cyclohexadienes

Abstract

Cyclitols are compounds that have been intensively researched due to their important biological activities. In this study, new bromocyclitol analogues were synthesized based on cyclohexene, 1,3-cyclohexadiene and 1,4-cyclohexadiene. Cyclitol analogues were obtained by cis-hydroxylation, acetylation and allylic bromination reactions. The structures of the obtained products were elucidated and their formation mechanisms were discussed in detail.

Keywords

• Bromocyclitol
• synthesis
• 1-3-cyclohexadiene
• 1-4-cyclohexadiene
• cis-hydroxylation

Siklohekzen ve Siklohekzadienlerden Bromosiklitollerin Sentezi

Öz

Siklitoller, önemli biyolojik aktiviteleri nedeniyle yoğun şekilde araştırılan bileşiklerdir. Bu çalışmada, siklohekzen, 1,3-siklohekzadien ve 1,4-siklohekzadien temel alınarak yeni bromosiklitol analoglarının sentezi gerçekleştirildi. cis-Hidroksilleme, asetilleme ve alilik bromlama reaksiyonları ile siklitol analoğu ürünler elde edildi. Elde edilen ürünlerin yapıları aydınlatıldı ve oluşum mekanizmaları detaylı bir şekilde tartışıldı.

Anahtar Kelimeler

• Bromosiklitol
• sentez
• 1-3-siklohekzadien
• 1-4-siklohekzadien
• cis-hidroksilleme

Kaynakça

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