Elektroeğrilmiş Nanofiber Yapıların Kanser Tedavisinde Kullanımı: Mevcut İlerlemeler ve Gelecek Persfektifler

Yıl 2023, Cilt: 3 Sayı: 2, 39 - 55, 21.11.2023

Gökmen Arabacı , Sumeray Ayan , Fatma Gündüz , Yasemin İspirli Doğaç

Öz

Nanoteknoloji, tıp bilimleri dahil olmak üzere hayatın hemen her alanında önemli bir rol oynamıştır. Nanoteknolojik ürünlerin önemli bir sınıfını da nanofiberler oluşturmaktadır. Nanofiberlerle biyomedikal uygulamalarla ilgili başlıca araştırma hatları, kontrollü ilaç salım uygulamaları için antitümör ilaçların kapsüllenmesini, doku mühendisliği ve rejeneratif tıp için iskele yapılarını ve ayrıca kanser tümörlerinin azaltılmasında uygulanacak manyetik veya plazmonik hipertermiyi kapsamaktadır. Özellikle, kemoterapide kullanılan genel antikanser ilaçlarının, yüksek doz kullanımları ile ciddi yan etkilerle ilişkili olması ve normal hücrelere de zarar vermesinden dolayı, kontrollü ve sürekli bir ilaç salınımı, faydalar sağlamaktadır. Bu amaçla kullanılan antikanser ilacı yüklü nanofiberler, ilacın daha uzun süre korunmasını ve daha az ilaçla sonuca ulaşılmasını sağladığı için önemli sonuçlara ulaşılmıştır. Elektrospun nanofiberler, çok geniş yüzey alanına, kontrol edilebilir gözenek boyutuna ve ayarlanabilir ilaç salım profillerine sahip olup, gelecek vadeden adaylardır. Elektroeğirme yönteminin nanofiber yapıları üretmede sunduğu göreceli kolaylık, farklı polimer yapıların, polimer veya inorganik maddelerin kompozit olarak kullanılabilmeleri, farklı boyut, şekil, gözenek boyutlarında üretilebilmeleri, dış ve/veya iç uyaranlara (pH, sıcaklık, manyetik alan, ışık vb.) yanıt verme yeteneklerine sahip olabilmeleri, yeni stratejilerin ve yeni araştırmaların sayısını oldukça arttırmaktadır. Bunun yanında, nanofiberlerin kanser tedavisinde uygulanmasına ilişkin çok sayıda araştırma raporu bulunmaktadır. Bu derleme makale, başarılı kanser tedavisi için rapor edilmiş, bazı elektrospun nanofiberlere genel bir yaklaşımla odaklanmaktadır.

Anahtar Kelimeler

Elektroeğirme, nanofiber, ilaç salımı, kanser tedavisi

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

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