Signalling Molecules Regulating Embryonic Development of Teeth

Öz

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Anahtar Kelimeler

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Dişin Embriyolojik Gelişimini Düzenleyen Sinyal Molekülleri

Öz

Diş gelişimi, erken embriyonik dönemde gerçekleşen önemli olaylardan biridir. Bu dönemde, embriyonik hücre göçünün zamanlamasında pek çok endojen ve eksojen faktörün iş gördüğü anlaşılmıştır. Gelişim biyolojisindeki en temel konulardan biri, doku sinyallerinin nasıl ve nereden gönderildiğidir. Biz de bu çalışmada, dişlerin embriyonik gelişimi üzerine etkisi olduğu düşünülen sinyalizasyon ağları hakkında derleme yapmayı amaçladık

Anahtar Kelimeler

• Diş, embriyoloji, histoloji, genetik, sinyal proteinleri

Kaynakça

1. Moore KL, Persaud TVN, (editors). Before We Are Born, Essentials of Embryology and Birth Defects, 4th ed. Philadelphia: W.B. Saunders Company; 1993. p. 320-322.
2. Sadler TW, (editor). Langman’s Medical Embryology, 10th ed. Lippincott Williams & Wilkins; 2006. p. 278-282.
3. Miletich I, Sharpe PT. Normal and abnormal dental development. Hum Mol Genet. 2003; (12): 69-73.
4. Tucker AS, Sharpe PT. Molecular genetics of tooth morphogenesisand patterning: the right shape in the right place. J Dent Res. 1999; (78): 826-834.
5. Mitsiadis TA, Chéraud Y, Sharpe P, Fontaine- Pérus J. Development of teeth in chick embryos after mouse neural crest transplantations. Proc Natl Acad Sci USA. 2003; (100): 6541-6545.
6. Thesleff I, Sharpe P. Signalling networks regulating dental development. Mech Dev. 1997; (67): 111-123.
7. http://patriciazuk.com/wlachstology/DH156Tooth Development.ppt
8. Thesleff I. Epithelial-mesenchymal signalling regulating tooth morphogenesis. J Cell Sci. 2003; (116): 1647-1648.

9. Jumlongras D, Bei M, Stimson JM, Wang WF, DePalma SR, Seidman CE, Felbor U, Maas R, Seidman JG, Olsen BR. A nonsense mutation in MSX1 causes Witkop syndrome. Am J Hum Genet. 2001; (69): 67-74.
10. Modesto A, Moreno LM, Krahn K, King S, Lidral AC. MSX1 and orofacial clefting with and without tooth agenesis. J Dent Res. 2006; (85): 542-546.
11. Matalova E, Fleischmannova J, Sharpe PT, Tucker AS. Tooth agenesis: from molecular genetics to molecular dentistry. J Dent Res. 2008; (87): 617-623.
12. Peters H, Neubüser A, Kratochwil K, Balling R. Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998; (12): 2735-2747.
13. Callahan N, Modesto A, Meira R, Seymen F, Patir A, Vieira AR. Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis. Arch Oral Biol. 2009; (54): 45-9.
14. Wang X, Yang J, Tao AL, Yang WL, Zhang HJ. Mutation analysis of p63 gene in the first Chinese family with ADULT syndrome. Chin Med J (Engl). 2009; (122): 1867-1871.
15. Brunner HG, Hamel BC, Van Bokhoven H. The p63 gene in EEC and other syndromes. J Med Genet. 2002; (39): 377-381.
16. Jernvall J, Kettunen P, Karavanova I, Martin LB and Thesleff I. Evidence for the role of enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells expressgrowth stimulating Fgf-4 gene. Int. J. Dev. Biol. 1994; (38): 463-469.
17. Salazar-Ciudad I, Jernvall J. A gene network model accounting for development and evolution of mammalian teeth. Proc Natl Acad Sci USA. 2002;( 9)9: 8116-8120.
18. Vaahtokari A, Aberg T, Jernvall J, Keränen S, Thesleff I. The enamel knot as a signaling center in the developing mouse tooth. Mech Dev. 1996; (54): 39-43.
19. Bei M, Stowell S, Maas R. Msx2 controls ameloblast terminal differentiation. Dev Dyn. 2004; (231): 758-765.
20. Golonzhka O, Metzger D, Bornert JM, Bay BK, Gross MK, Kioussi C, Leid M. Ctip2/Bcl11b controls ameloblast formation during mammalian odontogenesis. Proc Natl Acad Sci USA. 2009; (106): 4278-4283.
21. D'Souza RN, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I. Cbfa1 is required for epithelial-mesenchymal interactions regulating Development. 1999; (126): 2911-2920. in mice.
22. Mundlos S, Otto F, Mundlos C, Mulliken JB, Aylsworth AS, Albright S, Lindhout D, Cole WG, Henn W, Knoll JH, Owen MJ, Mertelsmann R, Zabel BU, Olsen BR. Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell. 1997; (89): 773-779.
23. Yılmaz HH, Uçok Ö, Doğan N, Özen T, Karakurumer K. Kleidokraniyal displazi (Olgu Raporu). Cumhuriyet Univ Dişhekimliği Fak Derg. 2002; (5): 33-35.
24. Bouwman P, Göllner H, Elsässer HP, Eckhoff G, Karis A, Grosveld F, Philipsen S, Suske G. Transcription factor Sp3 is essential for post- natal survival and late tooth development. EMBO J. 2000; (19): 655-661.