THE ROLE OF REACTIVE OXYGEN SPECIES IN PERIODONTAL TISSUE DESTRUCTION

Öz

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Anahtar Kelimeler

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PERİODONTAL DOKU YIKIMINDA REAKTİF OKSİJEN TÜRLERİNİN ROLÜ

Öz

Periodontal hastalıklarda doku yıkımı birkaç mekanizmanın ortak faaliyeti ile direkt ve indirekt olmak üzere iki şekilde gerçekleşir. Dişeti oluğunda ve periodontal cepte kolonize olan bakteriler ve bakterilerden kaynaklı çeşitli enzimler direkt yıkımdan sorumludur. İndirekt yıkım ise konak dokuda bakteriyel faktörlere karşı oluşan doku cevabının meydana getirdiği doku yıkımıdır. Bakteriler ve bakterilerin metabolik enzimleri, kemotaktik ajan olarak polimorfonükleer lökositlerin migrasyonuna yol açmakta, immünolojik sistem aktivasyonu ile enflamatuvar cevap oluşmaktadır. Aktive olmuş polimorfonükleer lökositler dokuyu mikroorganizmalardan korumak amacıyla çeşitli türde reaktif oksijen türlerini salarlar. Bu derlemede amacımız periodontal doku yıkım mekanizmalarına kısaca göz atmak ve reaktif oksijen türlerinin periodontal doku yıkımında oynadığı rolü sunmaktır

Anahtar Kelimeler

• Periodontal yıkım, Reaktif oksijen türleri, Oksidatif stresler

Kaynakça

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