NANOPARTİCLES IN DENTISTRY, THEIR APPLICATIONS, AND BIOCOMPATIBILITY

Öz

Nano-structured materials have been receiving considerable attention as a results of their unique physical and chemical properties, biological properties, and functionality due to their nano-scale size. Metallicbased nano-structured materials have created a new interesting field in all sciences for continuous investigations due to their unique properties. Dental materials with antimicrobial activity such as filling materials, cements, sealants, materials for temporary restorations, and adhesives have emerged. Their applications have led to development of new practical productions. They show good antimicrobial properties due to their large surface area to volume ratios. They can be used as effective growth inhibitors of various microorganisms. Furthermore, nanomaterials can be modified of achieve better efficiency and to facilitate their applications in different fields such as biomaterials and medicine. Nanoparticles have been used in dentistry as drug-delivery, caries control and remineralization, hypersensivity, oral biofilm management, periodontal management

Anahtar Kelimeler

• Nanotechnology
• dentistry
• nanoparticle
• anti-infection agent

DİŞ HEKİMLİĞİNDE KULLANILAN NANOPARTİKÜLLER, KULLANIM ALANLARI VE BİYOUYUMLULUK

Öz

Nanopartiküller nano boyutlarından dolayı fonksiyonellik, biyolojik özellikler, eşsiz fiziksel ve kimyasal özelliklerinin bir sonucu olarak büyük oranda dikkat çekmişlerdir. Metal esaslı nanomateryaller üstün özelliklerinden dolayı tüm bilim dallarında yeni bir ilgi alanı oluşturmuştur.  Bunların uygulamaları yeni pratik ürünlerin gelişmesine yol açmıştır.  Dolgu materyalleri, simanlar, fissür örtücüler, geçici restorasyonlar ve adezivler gibi antimikrobiyal etkiye sahip dental materyaller ortaya çıkmıştır. Metal nanopartiküller büyük yüzey alanı/hacim oranına sahip olduklarından dolayı iyi antimikrobiyal özellikler sergilerler. Bunlar çeşitli mikroorganizmaların büyüme inhibitörü olarak kullanılabilirler. Dahası, nanomateryallerin daha etkili olmaları biyomateryal ve tıp gibi farklı alanlarda kullanımlarını kolaylaştırmak için modifiye edilebilirler. Nanopartiküller ilaç salımı, çürük kontrolü ve remineralizasyon, biyofilm oluşumunun önlenmesi, periodontal enfeksiyon, kök kanal dezenfeksiyonu, dentin hassasiyetinin giderilmesi gibi diş hekimliğinin pek çok alanında kullanılmalarına rağmen bazı nanopartiküller oral ve diğer dokular için toksik olabilirler. İnsan hücreleri için nanoteknoloji ürünlerinin muhtemel toksisitesi ile ilgili bilgi sınırlıdır. Dental biyomateryaller üzerinde nanopartiküllerin uzun süreli antimikrobiyal, toksik, fiziksel ve klinik etkileri daha ileri çalışmalarda araştırılması gerekir.

Anahtar Kelimeler

• Nanoteknoloji
• diş hekimliği
• nanopartikül
• anti-mikrobiyal ajan

Kaynakça

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