KEMOTERAPİYE BAĞLI MUKOZİT

Öz

Kemoterapiye bağlı mukozit, sistemik kemote- rapinin kişiye sınırlı bir kopmplikasyonudur. Esas olarak hızlı bölünen epitelyal hücrelerin kemoterapi tarafından uyarılan hasarı ve reaktif oksijen radikallerinin artması ve salınması sonucu gelişir. Oral beslenmeyi bozması- nın yanı sıra mukozit aynı zamanda mikrobiyal ajanlara karşı mukozal bariyerin bozulması nedeniyle sistemik bakteriyemi, fungemi ve viremiye de yol açabilir. Her ne kadar çeşitli profilaktik ve terapötik yaklaşımlar mevcut olsa da bunlardan çoğu etkin değildir. Risk değerlendirmesi ve etkin önleyici tedavi gereklidir.   

Anahtar Kelimeler

• Kemoterapi, Mukozit

MUCOSITIS RELATED TO CHEMOTHERAPY

Öz

Chemotherapy induced mucositis is a self-limited complication of systemic chemotherapy. It is mainly due to the chemotherapy induced DNA damage of rapidly dividing epithelial cells and release and upregulation of reactive oxygene radicals. In addition to interfering oral nutrition, mucositis can also leads to systemic bacteriemia fungemia and viremia due to the destruction of mucosal barrier against microbial agents. Although, several prophylactic and therapeutic approaches are available, most of them are ineffective. Risk assesment and effective preventive treatment is mandatory

Anahtar Kelimeler

• Chemotherapy, mucositis

Kaynakça

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