GİNGİVAL METASTASİS FROM THE SQUAMOUS CELL CARCİNOMA OF THE LUNG: A CASE REPORT AND REVİEW OF THE LİTERATURE

Öz

Metastasis of a lung carcinoma to the gingiva is very uncommon, but it must be considered as a first sign of the primary tumour. Most reported cases involve the jaws rather than the soft tissues. The clinical presentation of gingival metastasis include: rapid growth, pain, swelling, chewing dysfunction, trismus, dysphagia and pathological fracture. However, the final diagnosis is based on the histopathological evaluation. In this case report, a 59 years-old male patient with a gingival metastasis from lung squamous cell carcinoma was presented. Also, the review of 23 case reports of the oral metastasis from lung carcinoma in English literature were demonstrated

Anahtar Kelimeler

• Squamous cell carcinoma, lung, metastasis, gingiva, oral cavity

SKUAMOZ HÜCRELİ AKCİĞER KARSİNOMUNUN GİNGİVA METASTAZI: VAKA RAPORU VE LİTERATÜR TARAMASI

Öz

Metastasis of a lung carcinoma to the gingiva is very uncommon, but it must be considered as a first sign of the primary tumour. Most reported cases involve the jaws rather than the soft tissues. The clinical presentation of gingival metastasis include: rapid growth, pain, swelling, chewing dysfunction, trismus, haemorrhagic tendency, paresthesia, dysphagia and pathological fracture. However, the final diagnosis is based on the histopathological evaluation. In this case report, a 59 years-old male patient with a gingival metastasis from lung squamous cell carcinoma was presented. Also, the review of 23 case reports of the oral metastasis from lung carcinoma in English literature were demonstrated.

Anahtar Kelimeler

• Skuamoz hücreli karsinom, akciğer, metastaz, gingiva, oral kavite

Kaynakça

1. You TK, Kim SR, Park HS, et al. Fine needle aspiration cytology of metastatic adenocarcinoma of the gingiva from the lung: a case report. Korean J Pathol 2012;46:101-4.
2. Hirshberg A, Leibovich P, Buchner A. Metastatic tumors to the jawbones: analysis of 390 cases. J Oral Pathol Med 1994;23:337-41. 3. Akarslan ZZ, Altundağ Osteonecrosis of the jaws related to bisphosphonate used for the treatment of bone metastatic prostate cancer: Acase report and review of the literature. J Ataturk Fac Dent 2008;18:105-10. Kahraman S.
3. Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, et al. Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol 2008;44:743-52.
4. Sauerborn D, Vidakovic B, Baranovic M, et al. Gastric adenocarcinoma metastases to the alveolar mucosa of the mandible: a case report and review of the literature. J Craniomaxillofac Surg 2011;39:645-8.
5. Alvarez-Alvarez C, Iglesias-Rodriguez B, Pazo- Irazu S, et al. Colonic adenocarcinoma with metastasis to the gingiva. Med Oral Patol Oral Cir Bucal 2006;11:85-7.
6. Curien R, Moizan H, Gerard E. Gingival metastasis of a bronchogenic adenocarcinoma: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:25-8. 8. Staalsen NH, Nielsen JS. Bronchogenic metastasis to the gingiva. Oral Surg Oral Med Oral Pathol 1992;74:561-2.
7. Vieira BJ, Aarestrup FM, da Fonseca EC, et al. Bilateral adenocarcinoma: report of a case. J Oral Maxillofac Surg 2001;59:1224-5. of lung
8. Huang CJ, Chang YL, Yang MC, et al. Lung cancer metastatic to the maxillary gingiva-a case report and literature review. Oral Oncol Ext 2005;41:118-20.

9. Pozzi EC, Altermatt HJ, Rees TD, et al. Exophytic mass of the gingiva as the first manifestation of metastatic Periodontol 2008;79:187-91. adenocarcinoma. J
10. Ravi Prakash SM, Verma S, Gill N, et al. Multiple gingival metastasis of adenocarcinoma of the lung. Indian J Dent Res 2012;23:558-9.
11. Kadokura M, Yamamoto S, Kataoka D, et al. Pulmonary adenocarcinoma metastatic to the gingiva. Int J Clin Oncol 1999;4:253-5.
12. Tanaka M, Hiraki A, Ueoka H, et al. Gingival metastasis in lung cancer. Oncol Rep 2002;9:571-4.
13. O'Neil R. Bronchial adenocarcinoma presenting as epulis. Br J Oral Surg 1964;2:148-50.
14. Ellis GL, Jensen JL, Reingold IM, et al. Malignant neoplasms metastatic to gingivae. Oral Surg Oral Med Oral Pathol 1977;44:238-45.
15. Donoff RB, Albert T, Olson DJ, et al. Metastatic bronchogenic carcinoma to the mandible. J Oral Surg 1976;34:1007-11.
16. Rajappa S, Loya AC, Rao R, et al. Metastasis to oral cavity-a report of two cases and review of the literature. Indian J Med Paed Oncol 2005;26:43-46
17. Aoe K, Hiraki A, Kohara H, et al. Gingival metastasis as initial presentation of small cell carcinoma of the lung. Anticancer Res 2003;23:4187-89.
18. Alández J, Llanes F, Herrera JI, et al. Metastatic lung carcinoma involving the periodontium. Report of a case. J Periodontol 1995;66:896-8.
19. Yoshii T, Muraoka S, Sano N, et al. Large cell carcinoma of the lung metastatic to the mandibular gingiva. J Periodontol 2002;73:571-4.
20. Adler CI, Sotereanos GC, Valdivieso JG. Metastatic bronchogenic carcinoma to the maxilla: report of case. J Oral Surg 1973;31:543- 6.
21. Peris K, Cerroni L, Paoloni M, et al. Gingival metastasis as first sign of an undifferentiated carcinoma of the lung. J Dermatol Surg Oncol 1994;20:407-9.
22. Sanner JR, Ramin JE, Yang CH. . Carcinoma of the lung metastatic to the gingiva: review of the literature and report of case. J Oral Surg 1979;37:103-6.
23. López-Jornet P, Garcia G, Camacho-Alonso F. Isolated gingival metastasis from lung carcinoma. N Y State Dent J 2011;77:27-8.
24. Jaguar GC, Prado JD, Soares F, et al. Gingival metastasis from non-small cell undifferentiated carcinoma of the lung mimicking a pyogenic granuloma. Oral Oncol Ext 2006;42:36-9.
25. Moharil RB, Khandekar S, Dive A. Metastatic lung malignancy to mandibular gingiva. Indian J Dent Res 2010;21:449-51.
26. Thomas ME, Koshi R. Electron microscopy in the diagnosis of malignant fibrous histiocytoma of the lung presenting as metastasis to the maxillary gingiva. Int J Oral Maxillofac Surg 2013;42:99-101.
27. Dhawad MS, Nimonkar PV.Metastatic carcinoma of gingiva mimicking pyogenic granuloma. J Maxillofac Oral Surg 2011;10:163-5.
28. Effiom OA, Adeyemo WL, Omitola OG, et al. Oral squamous cell carcinoma: a clinicopathologic review of 233 cases in Lagos, Nigeria. J Oral Maxillofac Surg 2008;66:1595-9.
29. Chidzonga MM, Mahomva L. Squamous cell carcinoma of the oral cavity, maxillary antrum and lip in a Zimbabwean population: a descriptive epidemiological study. Oral Oncol 2006;42:184-9.
30. Marx RE, Stern D. Oral and maxillofacial pathology: a rationale for diagnosis and treatment. Quintessence Publishing, Illinois, 2003;p:340-1.
31. Van Der Waal RIF, Buter J, Van Der Waal I. Oral metastasis: report of 24 cases. Br J Oral Maxillofac Surg 2003;41:3-6.
32. Seoane J, Van Der Waal I, Van Der Waal RIF, et al. Metastatic tumours to the oral cavity: asurvival study with a special focus on gingival metastasis. J Clin Periodontol 2009;36:488-92.