SCAFFOLDS USED IN PERIODONTAL TISSUE ENGINEERING

Öz

The main goal of periodontal treatment is to ensure complete regeneration of lost periodontal tissues. In recent years, alternative approaches to the treatment of periodontal tissues in regenerative tissue engineering applications has been seen frequently in the literature. In general, a scaffold that supports the new forming tissues, with stem cells providing tissue regeneration of lost tissues and growth factors contributing the regeneration are used in tissue engineering studies that performed utilizing the basic principles of biology and engineering. Scaffolds used in tissue engineering applications are consist of natural biomaterials such as collagen and chitosan, biodegradable synthetic polymers and inorganic materials along with composites and nanofibrous materials that product by utilizing the characteristics of these different materials. The aim of this review is to assess and analyze the scaffolds and its features which is an important part of regeneration and used in the periodontology field. applications of tissue engineering in

Anahtar Kelimeler

• periodontal regeneration, tissue engineering, scaffold

PERİODONTAL DOKU MÜHENDİSLİĞİNDE KULLANILAN İSKELE YAPILARI

Öz

Periodontal tedavinin ana hedefi kaybedilen periodontal dokuların tam rejenerasyonunun sağlanmasıdır. Son yıllarda, periodontal dokuların rejeneratif tedavilerine alternatif yaklaşımlar içerisinde doku mühendisliği uygulamalarının literaturde sıklıkla yer aldığı görülmektedir. Mühendislik ve biyolojinin temel prensiplerinden faydalanılarak gerçekleştirilen doku mühendisliği çalışmalarında genel olarak yeni oluşacak dokuları destekleyen bir iskele yapı ile kaybedilmiş dokuların rejenerasyonunu sağlayacak kök hücreler, rejenerasyona katkıda bulunacak büyüme faktörlerinden faydalanılmaktadır. Doku mühendisliği uygulamalarında kullanılan iskeleler, kollajen, kitosan gibi doğal biyomateryaller, biyobozunabilen sentetik polimerler ve inorganik materyaller ile bu farklı materyallerin özelliklerinden faydalanılarak yapılan kompozit ve nanofibröz yapılardan oluşmaktadır. Bu derlemenin amacı, doku mühendisliğinin periodontoloji alanındaki uygulamalarında kullanılan ve rejenerasyonun önemli bir unsuru olan iskele yapılarının (skafold) özelliklerinin değerlendirilmesidir.

Anahtar Kelimeler

• periodontal rejenerasyon, doku mühendisliği, iskele yapılar

Kaynakça

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