OLİGODONTİNİN GENETİK TEMELİ

Canan Bayraktar; Zuhal Kırzıoğlu

doi:10.17567/ataunidfd.718002

OLİGODONTİNİN GENETİK TEMELİ

Öz

Oligodonti, çeşitli nedenlerle altı ya da daha fazla dişin oluşmamasına bağlı izlenen bir sayı anomalisidir. Görülme sıklığı kıtalara, toplumlara ve cinsiyetlere göre farklılık göstermektedir. Diş gelişimi ağırlıklı olarak genetik kontrolü altında ilerlemektedir. Diş gelişimi sırasında 200'den fazla gen rol oynamakta ve bu genlerde meydana gelen mutasyonların, oligodontiye neden olduğu düşünülmektedir. Oligodontiye neden olan genlerde, bireyler arası önemli varyasyonlar bulunmakta ve oluşan gen mutasyonlarının oligodontiyle birlikte bazı anomalilere ve kanserlere neden olduğu ifade edilmektedir. Oligodontili bireylerde etiyolojinin belirlenmesi, bu durumu etkileyen genlerin, ileride neden olabileceği çeşitli sağlık problemlerinin de önüne geçilmesi açısından önem taşımaktadır. Derlememiz, daha önceki yayınlarda bildirilmiş olan oligodonti ile ilişkili insan genomundaki mutasyonları gözden geçirmek ve dahil olan farklı genler hakkında gene özgü detaylar sağlamak için hazırlanmıştır. Anahtar Kelimeler: Diş Eksikliği, Etiyoloji, Genetik

GENETIC BASIS OF OLIGODONTIA

Abstract

Oligodontia is a number anomaly that is observed due to the absence of six or more teeth for various reason. The prevalance of oligodontia have varies according to continents, societies and genders. Tooth development have proceed predominantly genetic control. More than 200 genes have play a role during dental development, and mutations in these genes are thought to cause oligodontia. There are important inter-individual differences in the genes that cause oligodontia, and it is stated that the gene mutations that cause oligodontia cause some anomalies and cancers. The determination of the etiology in individuals with oligodontia is important in order to prevent the various health problems that may be caused by the genes that affect this condition. Our review was prepared to review mutations in the human genome associated with oligodontia reported in previous publications and to provide gene-specific details about the different genes involved. Keywords: Tooth Agenesis, Etiology, Genetics

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Diş Hekimliği

Bölüm

Derleme

Yazarlar

Canan Bayraktar Bu kişi benim
0000-0003-1388-1778
Andorra

Zuhal Kırzıoğlu Bu kişi benim
0000-0002-3726-2392
Andorra

Yayımlanma Tarihi

15 Ocak 2021

Gönderilme Tarihi

28 Kasım 2019

Kabul Tarihi

10 Nisan 2020

Yayımlandığı Sayı

Yıl 2021 Cilt: 31 Sayı: 1

DOI

https://doi.org/10.17567/ataunidfd.718002

IZ

https://izlik.org/JA28FR59YT

Kaynak Göster

RIS / Bibtex

APA

Bayraktar, C., & Kırzıoğlu, Z. (2021). OLİGODONTİNİN GENETİK TEMELİ. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 31(1), 124-129. https://doi.org/10.17567/ataunidfd.718002

AMA

1.Bayraktar C, Kırzıoğlu Z. OLİGODONTİNİN GENETİK TEMELİ. Ata Diş Hek Fak Derg. 2021;31(1):124-129. doi:10.17567/ataunidfd.718002

Chicago

Bayraktar, Canan, ve Zuhal Kırzıoğlu. 2021. “OLİGODONTİNİN GENETİK TEMELİ”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 31 (1): 124-29. https://doi.org/10.17567/ataunidfd.718002.

EndNote

Bayraktar C, Kırzıoğlu Z (01 Ocak 2021) OLİGODONTİNİN GENETİK TEMELİ. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 31 1 124–129.

IEEE

[1]C. Bayraktar ve Z. Kırzıoğlu, “OLİGODONTİNİN GENETİK TEMELİ”, Ata Diş Hek Fak Derg, c. 31, sy 1, ss. 124–129, Oca. 2021, doi: 10.17567/ataunidfd.718002.

ISNAD

Bayraktar, Canan - Kırzıoğlu, Zuhal. “OLİGODONTİNİN GENETİK TEMELİ”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 31/1 (01 Ocak 2021): 124-129. https://doi.org/10.17567/ataunidfd.718002.

JAMA

1.Bayraktar C, Kırzıoğlu Z. OLİGODONTİNİN GENETİK TEMELİ. Ata Diş Hek Fak Derg. 2021;31:124–129.

MLA

Bayraktar, Canan, ve Zuhal Kırzıoğlu. “OLİGODONTİNİN GENETİK TEMELİ”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, c. 31, sy 1, Ocak 2021, ss. 124-9, doi:10.17567/ataunidfd.718002.

Vancouver

1.Canan Bayraktar, Zuhal Kırzıoğlu. OLİGODONTİNİN GENETİK TEMELİ. Ata Diş Hek Fak Derg. 01 Ocak 2021;31(1):124-9. doi:10.17567/ataunidfd.718002