MANDIBULANIN DEV HÜCRELI TÜMÖRÜ TEDAVISINDE FARMAKOLOJIK VE CERRAHI TEDAVI YAKLAŞIMLARI; 5 YILLIK TAKIP IÇEREN VAKA RAPORU

Yıl 2011, Cilt: 2011 Sayı: 2, 129 - 133, 01.02.2011

Yrd. Doç. Dr. Özgür Erdoğan Prof. Dr. Emin Esen Prof. Dr. Metin Yavuz

Öz

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Anahtar Kelimeler

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PHARMACOLOGICAL AND SURGICAL INTERVENTIONS FOR THE TREATMENT OF GIANT CELL TUMOR OF THE MANDIBLE; REPORT OF A CASE AFTER 5-YEAR FOLLOW-UP

Öz

Dev hücreli lezyonlar çene-yüz kemiklerinin nadir görülen tümörleridir. Tümör, agresif veya agresif olmayan klinik seyir gösterebilir. Cerrahi, temel tedavi yaklaşımıdır. Farmakolojik tedavi seçenekleri kalsitonin tedavisi, lezyon içi kortikosteroid enjeksiyonu ve interferon alfa tedavisini kapsar. Bu makalede, alt çenesinde dev hücreli tümör mevcut 30 yaşındaki bayan hastaya uygulanan lezyon içi kortikosteroid ve nasal kalsitonin inhalasyonu uygulamalarının 5 yıllık takip bulguları sunulacaktır

Anahtar Kelimeler

Anahtar Mandibula, Vaka raporu kelimeler: Dev hücreli tümör

Kaynakça

• Stewart JCB. Oral Pathology. Clinical-Pathologic Correlations. 1st Ed. Philadelphia, PA; W.B. Saunders Company; 1993. p. 411.
• Kratochvil F, Yih W, Zieper M, Meshul C, Gordon M. Comparison of giant cell lesions of cherubism, giant cell granulomas of the jaws and giant cell tumors of long bones using immunohistochemistry and electron microscopy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000; 90: 492493.
• Kaban LB, Troulis MJ, Ebb D, August M, Hornicek FJ, Dodson TB Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg 2002; 60: 1103-1111.
• Kurtz M, Mesa M, Alberto P. Treatment of a central giant cell lesion of the mandible with intralesional glucocorticosteroids. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001 ;91(6) :636-637.
• Terry BC, Jacoway JR: Management of central giant cell lesions: An alternative to surgical therapy. Oral Maxillofac Clin North Am 1994; 6: 579.
• Harris M. Central giant cell granulomas of the jaws regress with calcitonin therapy. Br J Oral Maxillofac Surg 1993; 31: 89-94.
• Pogrel MA, Regezi JA, Harris ST, Goldring SR. Calcitonin treatment for central giant cell granulomas of the mandible: Report of two cases. J Oral Maxillofac Surg 1999; 57: 848-853.
• Kaban LB, Mulliken JB, Ezekowitz RA, Ebb D, Smith PS, Folkman J. Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon alpha-2a. Pediatrics 1999; 103: 11451149.
• Eisenbud L, Stern M, Rothberg M, Sachs SA. Central giant cell granuloma of the jaws: experiences in management of thirtyseven cases. J Oral Maxillofac Surg 1988; 46: 376-384.
• Chuong R, Kaban LB, Kozakewich H, Perez-Atayde A. Central giant cell lesions of the jaws: A clinicopathologic study. J Oral Maxillofac Surg 1986; 44: 708-713.
• Carlos R, Sedano HO. Intralesional corticosteroids as an alternative treatment for central giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 93: 161-166.
• Kermer C, Millesi W, Watzke IM. Local injection of corticosteroids for central giant cell granuloma. A case report. Int J Oral Maxillofac Surg 1994; 23: 366-368.
• Adornato MC, Paticoff KA. Intralesional corticosteroid injection for treatment of central giant-cell granuloma. J Am Dent Assoc 2001; 132: 186-190.
• Robinson D, Segal M, Nevo Z. Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesis. Pathobiology 2002; 70: 333-342.
• Goldman KE, Marshall MK, Alessandrini E, Bernstein ML. Complications of alpha-interferon therapy for aggressive central giant cell lesion of the maxilla.Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 100: 285-291.
• Pogrel M.A. Calcitonin therapy for central giant cell granuloma. J Oral Maxillofac Surg 2003; 61: 649653.
• de Lange J, Rosenberg AJ, van den Akker HP, Koole R, Wirds JJ, van den Berg H. Treatment of central giant cell granuloma of the jaw with calcitonin. Int J Oral Maxillofac Surg 1999; 28: 372-376.
• O'Regan EM, Gibb DH, Odell EW. Rapid growth of giant cellgranuloma in pregnancy treated with calcitonin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 92: 532-538.
• de Lange J, van den Akker HP, van den Berg H, Richel DJ, Gortzak RA. Limited regression of central giant cell granuloma by interferon alpha after failed calcitonin therapy: a report of 2 cases. Int J Oral Maxillofac Surg 2006; 35(9): 865-869.
• de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104(5): 603-615.
• de Lange J, van Rijn RR, van den Berg H, van den Akker HP. Regression of central giant cell granuloma by a combination of imatinib and interferon: a case report. Br J Oral Maxillofac Surg 2009; 47(1): 59-61.
• Vered M, Buchner A, Dayan D. Giant cell granuloma of the jawbones--aproliferative vascular lesion? Immunohistochemical study with vascular endothelial growth factor and basic fibroblast growth factor. J Oral Pathol Med 2006; 35(10): 613-619.