IMPORTANCE OF STEM CELL IN PERIODONTAL REGENERATION

Yıl 2010, Cilt: 2010 Sayı: 2, 123 - 130, 01.02.2010

Dr. Erkan Özcan Dt. Sevil Sema Atuğ Özcan

Öz

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Anahtar Kelimeler

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PERİODONTAL REJENERASYONDA KÖK HÜCRENİN YERİ

Öz

Periodontal hastalıklar dişlerin etrafında sert ve yumuşak dokuları etkileyen iltihabi hastalıklardır. Bu hastalıklar dişetinin iltihabi hastalığı olan gingivitisle başlar. Tedavi edilmezse birtakım faktörlere bağlı olarak dişi destekleyen dokuların yıkımına, dişlerin mobilitesine ve hatta diş kayıplarına neden olabilirler. Periodontal tedaviler, genel olarak oluşan bu iltihabi durumun giderilmesi, doku yıkımının durdurulması ve hatta rejeneratif bir takım tedaviler uygulayarak kaybedilen dokuların tekrar kazanılmasını hedeflemektedir. Ancak bu rejeneratif uygulamalarda periodontal doku kazanımları sınırlı düzeyde olmaktadır. Bununla birlikte kök hücre ve doku mühendisliğindeki son gelişmeler sayesinde dental öncül hücreler, periodontitisin tedavisi, diş çürükleri ve pulpanın iyileştirilmesinde, kraniyofasial kemik ve diş dokularının rejenerasyonunda ve hatta tam olarak dişin yerine konmasında yeni yaklaşım olarak dikkati çekmektedir. Bu derlemede periodontal rejenerasyon ve dental kaynaklı kök hücre çalışmalarının önemi ve gelecekteki yerinden bahsedilecektir

Anahtar Kelimeler

Periodontitis, Rejenerasyon, Kök hücre

Kaynakça

• Pihlstrom BC, Bryan SM, Johnson NW. Periodontal Disease. Lancet 2005; 366: 1809- 1820.
• Vyas SP, Sihorcar V, Mishra V. Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases. J Clin Pharm Ther 2000; 25: 21-42.
• Nanci A, Bosshardt D. Structure of periodontal tissues in health and disease. Periodontology 2000. 2006; 40: 11-28.
• Şahin F, Saydam G, Omay SB. Kök hücre plastisitesi ve klinik pratikte kök hücre tedavsi. THOD 2005; 1(15): 48-56.
• Hayes R. Stem cells and public policy. The Basics 2006; New Yorg City: 6-7.
• Şenel F. Kök hücreler. Tübitak Bilim ve Teknik Dergisi 2002; 2-15.
• Nedel F, Almeida D, Oliveria I, Mabel M, Casagrande L, Fernando F. Therapeutic potential in dentistry. J Contemp Dent Pract 2009; 10(4):90-96.
• Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived fromhuman blastocysts. Science 1998; 282(5391): 1145- 1147.
• Trubiani O, Orsini G, Caputi S, Piatelli A. Adult mesechymal stem cells in dental research. Int. J. Immunopathol Pharmacol. 2006; 19(3): 451-460. 10. Morsczeck C, Schmalz G, Reichert TE, Völlner F, Galler K, Driemel O. Somatic stem cells for regenerative dentistry. Clin Oral Investig.2008; 12(2): 113-118.
• Lütfioğlu M. Periodontal rejenerasyon ve büyüme faktörleri. Atatürk Üniv.Diş Hek. Fak. Derg. 2007; 17(3): 35-43.
• Lin N-H, Gonthos S, Bartold PM. Stem cells and periodontal regeneration. Australian Dental Journal 2008; 53: 108-121.
• Hakkı SS, Demiralp B, Nohutçu RM. Periodontal rejenerasyon ve dentin. Hacettepe Diş Hekimliği Fakültesi Dergisi.2005; 29(4): 43-48.
• Toygar HU,Arpak N, Güzeldemir E. Farklı iki yapıda membran kullanılarak gerçekleştirilen yönlendirilmiş doku rejenerasyonu tekniğinin 5 yıllık klinik sonuçlarının değerlendirilmesi. A.Ü. Diş Hek. Fak. Derg. 2006; 33(1): 89-96.
• Nakashima M. Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic protein (BMP)-2 and -4. J Dent Res.1994; 73:1515-1522.
• Miura M, Gronthos S, Zhao M, Bai L, Fisher LW, Robey PG, Shi S. Shed: Stem cells from human exfolieted decidous teeth. Cell Biology 2003; 100(10): 5807-5812.
• Gonthos S, Brahin J, Li W, Fisher LW, Cherman N, Boyde A, Denbesten B, Robey PG, Shi S. Journal of Dental Research 2002; 81(8): 531- 535.
• Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells in vitro and in vivo. Cell Biology 2000; 97(25): 13625- 13630.
• Batouli S, Miura M, Brahi J, Tsutsui TW, Fisher LW, Gronthos S, Robey PG, Shi S. Comparison of stem-cell-mediated
• dentinogenesis. J Dent Res. 2003; 82(12): 976- 981. osteogenesis
• and 20. Abukowa H, Zhang W, Youn CS, Asrican R, Vacanti JP, Kaban LB, Trouls MJ, Yelick PC. Reconstructing mandibular defects autologous tissue-engineered tooth and bone constructs. J Oral Maxillofac Surg. 2009; 67(2): 335-47.
• Anderson H, Chen YK, Lin LM, Shieh TY, Chan A. Isolation and charecterization of dental pulp stem cells from a supernumerary tooth. J Oral Pathol Med 2008; 37: 571-574.
• Süzergöz F, Erdem AP, Sepet E, Bektaş M, Yalman N, Gürol AO. Dental pulpa kök hücrelerinin
• yeteneği ve kök hücre içeriğinin belirlenmesi üzerine bir ön çalışma. Türkiye Klinikleri J. Med. Sci. 2009; 29(1): 128-133. koloni
• oluşturma 23. Stevens A, Zuliani T, Olejnik C, Leroy H, Obriot H, Conte J, Formstecker P, Bailliez Y, Polokowsca RR. Human dental pulp stem cells differantiate into neural crest-derived melanocytes and have label retaining and sphere forming abilities. Stem Cells and Development 2008; 17: 1175-1184.
• Lang H, Schüler N, Nolden R. Attachment formation following replantation of cultured cells into periodontal defects–a study in mini pigs. J. Dent. Res. 1998; 77(2): 393-405.
• Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S. The efficacy of mesenchymal stem cells
• structures.2005; 8: 191-199.
• Seo BM, Miura M, Gronthos S, Bartold BM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004; 364: 149-155.
• Gronthos S, Mrozic K, Shi S, Bartold PM, Ovine periodontal ligament stem cells: Isolation, charecterization and differantiation potential. Calcified Tissue Int. 2006; 79: 310-317.
• dental 28. Kim SH , Kim KH, Seo BM , Koo KT, Kim T, Seol YJ, Young K, Rhyu C, Chung CP, Lee YM. Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in canine peri-implant defects model: A pilot study. J Periodontol 2009; posted online on july22.
• Liu Y, Zheng Y, Ding G, Fang D, Zhang C, Bartold PM, Gronthos S, Shi S, Wang S. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells. 2008; 26(4):1065-1073.
• Chun-jiao XU, Feng G, Qing-ping GAO, Ying-Fang WU, Xin-Chun J, Jie-Ying P. Effects of astragalus polysaccarides-chitosan /polylactic asid scaffolds and bone marrow stem cells on repairing supraalveolar periodontal defects in dogs. J. Cent South Univ (Med Sci) 2006; 31(4): 512-517.
• Tobita M, Uysal AC, Ogawa R, Hyakusoku H, Mizuno H. Periodontal Tissue Regeneration with Adipose-Derived Stem Cells. Tissue. Engine. 2007; 0(0).
• Ling W, Yao W, Yungfen L, Jing W, Nie X, Qiau J, Liu L, Tang W, Tian W. Osteogenic differantiation of adipose derived stem cells promoted by overexpression of osterix. Mol Cell Biocem 2007; 301: 83-92.
• Patricia AZ, Min Z, Ashjian P, Daniel A, Huang JI, Mizuno H, Zeni C, Fraser JK, Benhaim P, Marc H. Human adipose tissue is a source of multipotent stem cells. MBC Online 2002, 13(12): 4279-4295. 34. Strem BM, Hicok KC, Zhu M, Wulur I, Alfanso Z, Schreiber RE, Frase JK, Hedrick MH. Multipotantil differantiation of adipose tissue-derived stem cells. Keio J Med. 2005; 54(3): 132-141.
• Hassan Afizah, Zheng Yang, James H.P. Hui, Hong-Wei Ouyang, Eng-Hin Lee. A Comparison Between the Chondrogenic Potential of Human Bone Marrow Stem Cells (BMSCs) and Adipose- Derived Stem Cells (ADSCs) Taken from the Same Donors, Tissue. Engine. 2007; 13(4): 659- 666.
• Kawaguchi H, Hayashi H, Mizuno N, Fujita T, Hasegawa N, Shiba H, Nakamura S, Hino T, Yoshino H, Kurihara H, Tanaka H, Kimura A, Tsuji K, Kato Y. Cell transplantation for periodontal diseases. A novel periodontal tissue regenerative therapy using bone marrow mesenchymal 2005;15(7):99-104. cells. Clin
• Calcium. 37. Yamada Y, Ueda M, Hideharu H, Baba S. novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: A clinical case report. Int. J. Periodont. Rest. Dent. 2006; 26(4): 363-369.
• Kawaguchi H, Kurihara H. Clinical trial of periodontal tissue regeneration. Nippon Rinsho. 2008;66(5): 948-54.
• Prabhu A, Mehta DS. Periodontal regeneration-- fantasizing the future. Indian J Dent Res. 2003;14(4): 246-53.
• Morsczeck C, Schmalz G, Reichert TE, VölLner F, Galler K, Driemel O. Somatic stem cells for regenerative dentistry. Clin Oral Invest 2008; 12: 113-118.
• Ivanovski S, Gronthos S, Shi S, Bartold PM. Stem cell in the periodontal ligament. Oral Disease 2006; 12(4): 358-363.
• Sonoyoma W, Liu Y, Fang D, Yamaza T, Seo B, Zhang C, Liu H, Gronthos S, Wang C, Shi S, Wang S. Mesenchymal stem cell-mediated functional tooth regeneration in swine. Plosone 2006; 1(1): 1-8.
• Bluteau G, Luder H, Bari C, Mitsiadis TA, Stem cells for tooth engineering. Euro. Cel. and Materia 2008; 19:1-9.
• Völlner F, Driemel O, Reichert TE, Morsczeck C. Differentiation and charecterization of dental follicle precursor cells. Euro. Cel. and Materia 2007; 14(2): 111.
• Kemoun PH, Laurencin S, Rue J, Farges J, Salles JP, Brunel G. Human dental follicle cells acquire cementoblast features under BMP-2/-7 and enamel matrix derivates stimulation in vitro. Euro. Cel. and Materia 2007; 14(2): 93.
• Yokoi T, Saito M, Kiyono T, Iseki S, Kosaka K, Nishida E, Tsubakimoto T, Harada H, Noguchi T, Teranaka T. Establishment of immortalized dental follicle cells for generating periodontal ligament in vivo. Cell Tissue Res 2007; 327:301– 311.
• Taupine F, Adult periodontal–derived neural progenitor and stem cell. Expert Opinion On Therapeutic Patents. 2009; 19: 715-719.
• Krebsbach PH, Robey PG, Dental and skeletal stem cells: potential cellular therapeutics for craniofacial regeneration. J Dent Educ 2002; 66(6): 766-773.