PERİODONTAL TEDAVİDE YENİ YAKLAŞIM: İLERİ BASAMAK ÇÖZÜCÜ LİPİD MEDYATÖRLERİ

Yıl 2016, Supplement 16, 108 - 113, 24.11.2016

Burak Doğan , Esra Sinem Kemer Doğan Behiye Bolgül

https://doi.org/10.17567/ataunidfd.290590

Öz

ÖZ

Sağlığın
devam ettirilebilmesi için akut enflamatuvar yanıtın tamamen çözülmesi ve
vücudun homeostazise dönmesi gerekmektedir. Enflamatuvar yanıtta rol alan
lökositlerin, ortamda ölü hücre ve ürünlerini bırakma- yacak şekilde
kaldırılması ideal sonuç olmakla birlikte periodontal hastalıkta ve birçok
farklı sistemik hasta- lıkta, benzer şekilde kontrol altına alınamayan ve çözü-
lememiş bir enflamatuvar durumun oluştuğu görülmektedir.

Bugüne
kadar çalışılan antienflamatuvar ajanlardan steroidler, steroid olmayan
antienflamatuvar ilaçlar ve antihistaminikler, akut enflamatuvar yanıtın
başlama- sında rol alan anahtar proenflamatuvar medyatör yollarını bloke
ederler ve enflamasyonun kardinal bulgularının kontrolünde rol almaktadırlar.
Bu terapötik yaklaşım, birçok enflamatuvar hastalığın tedavisinde temel konumda
yer alsa da beraberinde oluşan yan etkilerin de göz ardı edilmemesi gerektiği
bir gerçektir.

Son
yıllarda, enflamasyonla ilişkili moleküler temellerin ortaya konulmasıyla
birlikte, enflamasyonun çözülme- sinin aktif ve agonist ilişkili
bir süreç olduğu ve doku homeostazisine dönüşün çok dikkatli bir şekilde düzen-
lendiği anlaşılmıştır. Enflamasyonun çözülmesinin yeni bir sınıf olan ileri
basamak çözücü lipid medyatörleri (İBÇLM) tarafından düzenlendiğinin
anlaşılmasıyla birlikte, periodontal patolojinin önlenmesinde ve enfla- matuvar
lökositlerin eliminasyonunda, İBÇLM molekül- lerinin potansiyel kullanımlarına
olan ilginin arttığı görülmektedir.

Bu
derlemede, İBÇLM’lerin enflamatuvar süreçte ve periodontal hastalık
patogenezindeki önemi ortaya konulmaya çalışılmıştır.

Anahtar sözcükler: Periodontal
hastalıklar, inflamasyon, yağ asidleri

 

A NEW APPROACH IN PERIODONTAL TREATMENT: PRORESOLVING LIPID MEDIATORS

ABSTRACT

 

Complete resolution of acute inflammatory response and
returning the body to homeostasis is crucial for on-going health. Although
removing of leukocytes in inflammation area without leaving any dead cells or
their products behind is an ideal result, it appears that uncontrolled and
unresolved inflammatory condition occurs in periodontal disease and various
systemic diseases similarly.

Most of the antiinflammatory agents studied up to now
such as steroids, non-steroid antiinflammatory drugs and antihistamines bloke
key proinflammatory mediator ways in the initiation of acute inflammatory
response or take part in the control of the cardinal symptoms. Despite this
therapeutic approach is a basic principle for the treatment of many inflammatory
diseases, it’s clear that adverse effects should not be ignored.  

Recently, after the determination of the inflammatory
basics, we understood that inflammatory resolution is an active and agonist
related process and returning to the tissue homeostasis is arranged very
carefully. Together with the understanding of the inflammatory resolution is
arranged by new classification of proresolving lipid mediators (PRLMs), the
interest on these molecules related to the prevention of periodontal pathology and
elimination of inflammatory leukocytes have increased.

In this review, we aimed to put forward the importance
of the PRLMs on the inflammatory process and periodontal pathogenesis.  

Keywords: Periodontal diseases, inflammation, fatty acids

Anahtar Kelimeler

Periodontal hastalıklar, inflamasyon

Kaynakça

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