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DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME)

Yıl 2019, Cilt: 29 Sayı: 4, 691 - 700, 15.10.2019
https://doi.org/10.17567/ataunidfd.443195

Öz



Biyoteknoloji
alanındaki gelişmeler, medikal araştırmalarda gen tedavisini ön plana çıkarmış
ve günümüz genetik prensiplerinin ağız diş sağlığını geliştirmek için
kullanılmasına yol açmıştır. Bu yeni teknolojilerinin diş hekimliği ile
buluşmasını; restoratif biyometaryallerin üretiminde kaydedilen bilimsel
aşamalar, doku mühendisliği, moleküler biyolojinin kullanımı ve insan genom
projesi sağlamıştır. Gen tedavisi, defektli genin özel bir yöntem kullanılarak tedavi
edici bir gen ile değiştirilmesi veya tamir edilmesidir. Birçok hastalığın
tedavisinde ve genetik bozuklukların düzeltilmesinde kullanılabilmektedir. Gen
tedavisinin diş hekimliğinde dentofasiyal uygulama alanları arasında kemik
rejenerasyonu, DNA bazlı immunizasyon (çürük ve periodontal hastalıklar), ağrı
tedavisi, otoimmun hastalıkların tedavisi ve kanser tedavisi yer almaktadır.
Genel olarak araştırmalarda yeni vektör sistemlerinin ve taşıma metotlarının
geliştirilmesi, bunların test edilmesi, vektör transdüksiyonunu içeren
mekanizmaların açıklığa kavuşturulması ve en iyi sonuç verebilecek
yaklaşımların klinik deneylerde kullanılmasına çalışılmaktadır. Geçtiğimiz 15
yılda gen ve ilaç taşıyıcı sistemler için çeşitli vektörler geliştirilmeye
çalışılmıştır. Gen tedavisi, diş hekimliği alanında bilimsel bazda önemli
etkiye sahiptir. Bu derlemede gen tedavisi metotları, ilgili vektörler, gen
tedavisinin diş hekimliğinde klinik etkisi ve konuya ilişkin bilimsel bilgilerin
güncellenmesi amaçlanmıştır.



Anahtar Kelimeler:
diş
hekimliği, genetik, gen tedavisi, genetik vektörler



 

GENE THERAPY IN DENTISTRY (REVIEW) 



ABSTRACT



Advances in
biotechnology have brought gene therapy to a
very important and
active area of 
medical research and currently genetic principles are being applied along to improve oral
health. Scientific advances in restorative biomaterials, tissue
engineering, molecular biology and the human genome project
provide the
basis for the introduction of new technologies into dentistry. Gene therapy is
a particular method by which missing or defective genes are replaced or
repaired by normal genes. It can be used to treat wide range of diseases and
correct genetics disorders. In dentistry the application of gene therapy to dentofacial
problems includes bone regeneration, DNA based immunization (for caries and
periodontal disease), pain, for treating auto immune disease and cancer. The
general approach is to develop new vector systems and delivery methods, test
them, uncover the mechanisms involved in vector transduction, and use the most
promising approaches in clinical trials. For the past 15 years various vectors
have been designed for improved gene and drug delivery. This field is having
significant impact on topics related to dental practice.
The aim of this
review is to provide an update on gene therapy methods, its clinical
implication in dentistry and scientific information associated with gene
therapy.



Key Words: dentistry; genetics;
gene therapy; genetic vectors



Kaynakça

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Toplam 59 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Diş Hekimliği
Bölüm Derleme
Yazarlar

Yelda Kasımoğlu 0000-0003-1022-2486

Mine Koruyucu Bu kişi benim 0000-0002-2077-5095

Figen Seymen Bu kişi benim 0000-0003-1713-0461

Yayımlanma Tarihi 15 Ekim 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 29 Sayı: 4

Kaynak Göster

APA Kasımoğlu, Y., Koruyucu, M., & Seymen, F. (2019). DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME). Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 29(4), 691-700. https://doi.org/10.17567/ataunidfd.443195
AMA Kasımoğlu Y, Koruyucu M, Seymen F. DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME). Ata Diş Hek Fak Derg. Ekim 2019;29(4):691-700. doi:10.17567/ataunidfd.443195
Chicago Kasımoğlu, Yelda, Mine Koruyucu, ve Figen Seymen. “DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME)”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29, sy. 4 (Ekim 2019): 691-700. https://doi.org/10.17567/ataunidfd.443195.
EndNote Kasımoğlu Y, Koruyucu M, Seymen F (01 Ekim 2019) DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME). Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29 4 691–700.
IEEE Y. Kasımoğlu, M. Koruyucu, ve F. Seymen, “DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME)”, Ata Diş Hek Fak Derg, c. 29, sy. 4, ss. 691–700, 2019, doi: 10.17567/ataunidfd.443195.
ISNAD Kasımoğlu, Yelda vd. “DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME)”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 29/4 (Ekim 2019), 691-700. https://doi.org/10.17567/ataunidfd.443195.
JAMA Kasımoğlu Y, Koruyucu M, Seymen F. DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME). Ata Diş Hek Fak Derg. 2019;29:691–700.
MLA Kasımoğlu, Yelda vd. “DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME)”. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, c. 29, sy. 4, 2019, ss. 691-00, doi:10.17567/ataunidfd.443195.
Vancouver Kasımoğlu Y, Koruyucu M, Seymen F. DİŞ HEKİMLİĞİNDE GEN TEDAVİSİ (DERLEME). Ata Diş Hek Fak Derg. 2019;29(4):691-700.

Cited By

GEN TERAPİSİNDE CRISPR-CAS9
Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi
Elif Tuğçe SAMSUNLU
https://doi.org/10.34087/cbusbed.905029

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