NAR KABUĞUNUN SAĞLIĞI GELİŞTİRİCİ VE HASTALIK ÖNLEYİCİ AKTİVİTESİ

Yıl 2024, , 101 - 108, 03.06.2024

Betül Koçak , Kardelen Yoldaş

https://doi.org/10.54270/atljm.2024.52

Öz

Nar kabuğu, potansiyel sağlık yararları ile birlikte güçlü antioksidan aktivite içerir. Nar kabuğunun, polifenol bakımından zengin olması nedeniyle antikanser potansiyelinin araştırıldığı çalışmalar mevcuttur. Nar kabuğunun, in vitro, in vivo ve klinik deneylerde farklı kanser hücre dizileri üzerinde antiproliferatif etkiler göstermiştir. Bu derlemenin amacı nar kabuğunun çeşitli kanser hastalıklarına karşı fonksiyonel özelliklerini ve tıbbi faydalarını değerlendirmektir. Ek olarak, nar kabuğunun in vitro ve in vivo insan ve hayvan klinik deneylerinde kullanımının çeşitli sağlık sorunları üzerine etkisine de yer verilmiştir. Mevcut veriler, Punica granatum (nar) kabuğunun bazı hastalık durumlarının gelişmesinde engelleyici ve potansiyel terapötik olarak kullanılabileceğini ve insan sağlığına fayda sağladığını göstermektedir. Bu derlemede nar kabuğunun potansiyel sağlık yararları, geleneksel tıbbi tedavide kullanımı ve kanser ilerlemesini engelleme mekanizması vurgulanmıştır.

Anahtar Kelimeler

Punica granatum, Punikalin, Pedunculagin

HEALTH-IMPROVING AND DISEASE PREVENTIVE ACTIVITY OF POMEGRANATE PEEL

Öz

Pomegranate peel contains powerful antioxidant activity along with potential health benefits. There are studies investigating the anticancer potential of pomegranate peel because it is rich in polyphenols. Pomegranate peel has shown antiproliferative effects on different cancer cell lines in in vitro, in vivo and clinical trials. The purpose of this review is to evaluate the functional properties and medicinal benefits of pomegranate peel against various cancer diseases. In addition, the effects of the use of pomegranate peel in in vitro and in vivo human and animal clinical trials on various health problems are also included. Available data indicate that Punica granatum (pomegranate) peel can be used as an inhibitory and potential therapeutic in the development of some disease conditions and benefits human health. This review highlights the potential health benefits of pomegranate peel, its use in traditional medical therapy, and its mechanism of inhibiting cancer progression.

Anahtar Kelimeler

Punica granatum, Punikalin, Pedunculagin

Kaynakça

• Longtin R. The pomegranate: nature's power fruit? CancerSpectrum Knowledge Environment. 2003;95(5):346-8.
• Ahangari B, Sargolzaei J. Extraction of pomegranate seed oil using subcritical propane and supercritical carbon dioxide. Theoretical Foundations of Chemical Engineering. 2012;46(3):258-65.
• Zahin M, Aqil F, Ahmad I. Broad spectrum antimutagenic activity of antioxidant active fraction of Punica granatum L. peel extracts. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2010;703(2):99-107.
• Pai V, Chanu TR, Chakraborty R, Raju B, Lobo R, Ballal M. Evaluation of the antimicrobial activity of Punica granatum peel against the enteric pathogens: an in vitro study. Asian Journal of Plant Science and Research. 2011;1(2):57-62.
• Lansky EP, Newman RA. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. Journal of ethnopharmacology. 2007;109(2):177-206.
• Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential antiinflammatory and anti-infective effects. Journal of ethnopharmacology. 2012;143(2):397-405.
• Amruthesh S. Dentistry & Ayurveda V-An evidence based approach. International Journal of Clinical Dental Science. 2011;2(1).
• Amakura Y, Okada M, Tsuji S, Tonogai Y. High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits. Journal of Chromatography A. 2000;896(1-2):87-93.
• Bassiri-Jahromi S. Punica granatum (Pomegranate) activity in health promotion and cancer prevention. Oncology reviews. 2018;12(1).
• Larrosa M, González-Sarrías A, García-Conesa MT, Tomás-Barberán FA, Espín JC. Urolithins, ellagic acid-derived metabolites produced by human colonic microflora, exhibit estrogenic and antiestrogenic activities. Journal of agricultural and food chemistry. 2006;54(5):1611-20.
• Lei F, Zhang X, Wang W, Xing D, Xie W, Su H, et al. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. International Journal of Obesity. 2007;31(6):1023-9.
• Akbarpour V, Hemmati K, Sharifani M. Physical and chemical properties of pomegranate (Punica granatum L.) fruit in maturation stage. American-Eurasian Journal of Agricultural & Environmental Sciences. 2009;6(4):411-6.
• Fischer UA, Carle R, Kammerer DR. Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD–ESI/MSn. Food chemistry. 2011;127(2):807-21.
• Qu W, Pan Z, Ma H. Extraction modeling and activities of antioxidants from pomegranate marc. Journal of food engineering. 2010;99(1):16-23.
• Lu J, Yuan Q. A new method for ellagic acid production from pomegranate husk. Journal of food process engineering. 2008;31(4):443-54.
• VIUDA‐MARTOS M, PÉREZ‐ÁLVAREZ JA, Sendra E, FERNÁNDEZ‐LÓPEZ J. In vitro antioxidant properties of pomegranate (Punica granatum) peel powder extract obtained as coproduct in the juice extraction process. Journal of Food Processing and Preservation. 2013;37(5):772-6.
• Tehranifar A, Selahvarzi Y, Kharrazi M, Bakhsh VJ. High potential of agro-industrial byproducts of pomegranate (Punica granatum L.) as the powerful antifungal and antioxidant substances. Industrial Crops and Products. 2011;34(3):1523-7.
• Chen B, Tuuli MG, Longtine MS, Shin JS, Lawrence R, Inder T, et al. Pomegranate juice and punicalagin attenuate oxidative stress and apoptosis in human placenta and in human placental trophoblasts. American Journal of Physiology-Endocrinology and Metabolism. 2012;302(9):E1142- E52.
• Khateeb J, Gantman A, Kreitenberg AJ, Aviram M, Fuhrman B. Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-γ pathway. Atherosclerosis. 2010;208(1):119-25.
• Larrosa M, García-Conesa MT, Espín JC, Tomás-Barberán FA. Ellagitannins, ellagic acid and vascular health. Molecular aspects of medicine. 2010;31(6):513-39.
• Hassanpour Fard M, Ghule AE, Bodhankar SL, Dikshit M. Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat. Pharmaceutical Biology. 2011;49(4):377-82.
• Hossin FLA. Effect of pomegranate (Punica granatum) peels and it’s extract on obese hypercholesterolemic rats. Pak J Nutr. 2009;8(8):1251-7.
• Panichayupakaranant P, Tewtrakul S, Yuenyongsawad S. Antibacterial, anti-inflammatory and anti-allergic activities of standardised pomegranate rind extract. Food Chemistry. 2010;123(2):400-3.
• Lee S-I, Kim B-S, Kim K-S, Lee S, Shin K-S, Lim J-S. Immune-suppressive activity of punicalagin via inhibition of NFAT activation. Biochemical and biophysical research communications. 2008;371(4):799-803.
• Sartippour MR, Seeram NP, Rao JY, Moro A, Harris DM, Henning SM, et al. Ellagitanninrich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. International journal of oncology. 2008;32(2):475-80.
• Yoshimura M, Watanabe Y, Kasai K, Yamakoshi J, Koga T. Inhibitory effect of an ellagic acid-rich pomegranate extract on tyrosinase activity and ultraviolet-induced pigmentation. Bioscience, biotechnology, and biochemistry. 2005;69(12):2368-73.
• Afaq F, Zaid MA, Khan N, Dreher M, Mukhtar H. Protective effect of pomegranate‐derived products on UVB‐mediated damage in human reconstituted skin. Experimental dermatology. 2009;18(6):553-61.
• Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, et al. Pomegranate fruit extract impairs invasion and motility in human breast cancer. Integrative cancer therapies. 2009;8(3):242-53.
• Aiyer HS, Bouker KB, Cook KL, Facey CO, Hu R, Schwartz JL, et al. Interaction of dietary polyphenols with molecular signaling pathways of antiestrogen resistance: possible role in breast cancer recurrence. Hormone Molecular Biology and Clinical Investigation. 2012;9(2):127-41.
• Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate ellagitannin–derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prevention Research. 2010;3(1):108-13.
• Al-Zoreky N. Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. International journal of food microbiology. 2009;134(3):244-8.
• Kotwal GJ. Genetic diversity-independent neutralization of pandemic viruses (eg HIV), potentially pandemic (eg H5N1 strain of influenza) and carcinogenic (eg HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing compounds (EVNCs). Vaccine. 2008;26(24):3055-8.
• Ajaikumar K, Asheef M, Babu B, Padikkala J. The inhibition of gastric mucosal injury by Punica granatum L.(pomegranate) methanolic extract. Journal of Ethnopharmacology. 2005;96(1- 2):171-6.
• Sánchez-Lamar A, Fonseca G, Fuentes JL, Cozzi R, Cundari E, Fiore M, et al. Assessment of the genotoxic risk of Punica granatum L.(Punicaceae) whole fruit extracts. Journal of Ethnopharmacology. 2008;115(3):416-22.
• Sen S, Chakraborty R, Sridhar C, Reddy Y, De B. Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect. International journal of pharmaceutical sciences review and research. 2010;3(1):91-100.