PREDICTING AND DETECTING POLYPHARMACY-RELATED DRUG INTERACTIONS AND FRAILTY : GERIATRICS

Öz

Background: Frailty is a situation that has become increasingly important in recent years. The study's objective was to investigate the connection between frailty and drug-drug interactions brought on by polypharmacy in older adults. Methods: 180 older adults admitted from the family practice medicine department between January 2022 to June 2022 were included. People over the age of 65 who applied to the family medicine outpatient clinic were included in the study. Results: The most prevalent comorbidities were hypertension (71.6%), diabetes (31.1%), and arthrosis (19.4%) in individuals with polypharmacy-related drug-drug interactions, antihypertensive medicines had the most interactions across all interaction classes. Polypharmacy-related drug-drug interactions were found in 130 (72.2%) of 180 patients included in the study. Conclusions: In the study, the frailty score was found to be statistically significantly worse in the 65 years and older with polypharmacy-related drug-drug interactions, according to age, comorbidities, and the number of drugs.

Anahtar Kelimeler

• Frailty
• Drug Interactions
• Polypharmacy

POLİFARMASİ İLE İLİŞKİLİ İLAÇ ETKİLEŞİMLERİNİN VE KIRILGANLIĞIN ÖNGÖRÜLMESİ VE TESPİTİ : GERİATRİ

Öz

Giriş ve Amaç: Kırılganlık son yıllarda önemi giderek artan bir durumdur. Çalışmanın amacı, yaşlı yetişkinlerde polifarmasinin neden olduğu ilaç-ilaç etkileşimleri ile kırılganlık arasındaki bağlantıyı araştırmaktır. Yöntemler: Ocak 2022 ile Haziran 2022 tarihleri arasında aile hekimliği bölümüne başvuran 180 yaşlı yetişkin çalışmaya dahil edildi. Aile hekimliği polikliniğine başvuran 65 yaş üstü kişiler çalışmaya dahil edildi. Bulgular: Polifarmasi ilişkili ilaç-ilaç etkileşimi olan bireylerde en yaygın komorbiditeler hipertansiyon (%71,6), diyabet (%31,1) ve artroz (%19,4) olup, antihipertansif ilaçlar tüm etkileşim sınıflarında en fazla etkileşime sahipti. Çalışmaya dahil edilen 180 hastanın 130'unda (%72,2) polifarmasi ilişkili ilaç-ilaç etkileşimi saptanmıştır. Sonuçlar: Çalışmada, polifarmasi ile ilişkili ilaç-ilaç etkileşimi olan 65 yaş ve üzeri hastalarda kırılganlık skoru yaş, komorbiditeler ve ilaç sayısına göre istatistiksel olarak anlamlı derecede daha kötü bulunmuştur.

Anahtar Kelimeler

• Kırılganlık
• İlaç-ilaç etkileşimi
• Polifarmasi

Etik Beyan

Declarations Ethical Approval This research complies with all relevant national regulations, institutional policies, and the principles of the Declaration of Helsinki, and Istanbul Atlas University Ethics Committee (approval number: E-22686390-050.01.04-10991) and Kocaeli Governorship, Provincial Health Directorate Scientific Research Studies Health Facility (approval number: E-65530689-799). The rights of all participants were protected and written informed consent was obtained prior to the procedures according to the Declaration of Helsinki.

Teşekkür

We thanks for Republic of Turkey Ministry of Health and Gebze Family Health Centre.

Kaynakça

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