Bio-Heat Transfer in Cancer Treatment: A Mathematical Framework for Hyperthermia-Assisted Radiotherapy Using Monte Carlo Simulation
Öz
This study explores bio-heat transfer during radiotherapy combined with hyperthermia, with the goal of improving cancer treatment by maximizing tumor destruction while minimizing harm to surrounding healthy tissue. Understanding thermal dynamics during therapy allows clinicians to enhance treatment effectiveness, anticipate biological responses based on dose parameters, and reduce side effects. In this work, we focus on the synergistic use of hyperthermia and X-ray radiotherapy. During short recovery periods between hyperthermia pulses—when tissue responds to elevated temperatures (43 °C, 45 °C, 47 °C)—radiation is delivered. The central hypothesis is that heating tumor tissue increases its radiosensitivity, potentially shortening treatment time and improving outcomes. Evidence from current literature supports this synergy, showing that higher temperatures amplify cellular damage. To quantify this effect, we applied the Arrhenius damage model, which converts temperature and exposure duration into a single thermal damage parameter (Ω) representing irreversible tissue injury. Finally, we developed a mathematical framework to simulate this process, using Monte Carlo photon transport to generate spatial heat sources and solving Pennes’ bio-heat equation to model heat transfer across layered biological tissue.
Anahtar Kelimeler
Heat transfer, Pennes’ bioheat equation, cancer treatment, radiotherapy, X-ray hyperthermia, Monti Carlo simulation.
Destekleyen Kurum
Gaziantep University
Etik Beyan
As the author of this paper, I declare that I conducted this research, and no ethical issues or review committee were required.
Teşekkür
Thanks to my supervisor, Prof. Dr. Recep YUMURTAS
Kaynakça
- Mee, T., Kirkby, N. F., Defourny, N. N., Kirkby, K. J. and Burnet, N. G., (2023). The use of radiotherapy, surgery and chemotherapy in the curative treatment of cancer: results from the FORTY (Favourable Outcomes from RadioTherapY) project, British Journal of Radiology, 96, 1152.
- Lukácsi, S., Munkácsy, G. and Győrffy, B., (2024). Harnessing Hyperthermia: Molecular, Cellular, and Immunological Insights for Enhanced Anticancer Therapies, Integrative Cancer Therapies. 15347354241242094.
- Yang, Y., Huangfu, L., Li, H., & Yang, D. (2023). Research progress of hyperthermia in tumor therapy by influencing metabolic reprogramming of tumor cells. International Journal of Hyperthermia, 40(1) 2270654.
- Kok HP, Herrera TD, Crezee J. (2024). Biological treatment evaluation in thermoradiotherapy: application in cervical cancer patients. Strahlentherapie and Onkologie. 200 (6), 512-522.
- Datta, N. R., Rogers, S., Ordóñez, S. G., Puric, E., & Bodis, S. (2016). Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis. International Journal of Hyperthermia, 32(1), 31–40.
- Datta, N.R., Puric, E., Klingbiel, D., Gomez, S., Bodis, S., (2016). Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis. International Journal of Radiation Oncology, Biology, Physics 94 (5), 1073-1087.
- Van Dieren, L., Quisenaerts, T., Licata, M., Beddok, A., Lellouch, A. G., Ysebaert, D., Saldien, V., Peeters, M., & Gorbaslieva, I. (2024). Combined Radiotherapy and Hyperthermia: A Systematic Review of Immunological Synergies for Amplifying Radiation-Induced Abscopal Effects. Cancers, 16(21), 3656.
- Issels RD, Lindner LH, Verweij J, et al. (2018). Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial. JAMA Oncol. 4(4), 483–492.
- Zachou, M.-E., Spyratou, E., Lagopati, N., Platoni, K., & Efstathopoulos, E. P. (2025). Recent Progress of Nanomedicine for the Synergetic Treatment of Radiotherapy (RT) and Photothermal Treatment (PTT). Cancers, 17 (14), 2295.
- Arslan, S. A., Ozdemir, N., Sendur, M. A., et al. (2017). Hyperthermia and Radiotherapy Combination for Locoregional Recurrences of Breast Cancer: A Review. Breast Cancer Management, 6(4), 117–126.