GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS

Dilek Burukoğlu; Emine Sunal; Fatma Kılıç; Sema Uslu; Setenay Öner; Ayla Eker Sarıboyacı; Dilek Burukoğlu; Murat Kılıçoğlu

EN TR

GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS

Öz

The present study was designed to test the hypothesis that cholesterol rich diet-induced hypercholesterolemia in rabbits can be reversed by long-term treatment of antioxidants (proanthocyanidin and silymarin) and antihyperlipidemic drug(simvastatin). In this study 35 adult New Zealand White (NZW) male rabbits were used and divided into five groups. The rabbits in Group 1(control) was fed with rabbit chow diet. Group 2 was fed with only cholesterol (2% w/w) rich diet to induce hypercholesterolemia. The other groups received GPSE 100mg/kg (Group 3), silymarin 10mg/kg (Group 4) and simvastatin10mg/kg (Group 5) with cholesterol in addition to rabbit chow diet. At the end of the experiment, the animals were sacrified and their aorta were excised for intimal lesion analysis. Vessells were dissected, trimmed, and then placed fixed in neutral formalin. All tissue sections were stained with hematoxylin and eosin(H&E). Apoptotic process was detected by using TUNEL.

Cholesterol treatment produced a sustainable state of atheromatous plaque formation In addition, only cholesterol rich diet-induced animals have shown a considerably high number apoptotic cells by using TUNEL and plasma total cholesterol (TC) and low density lipoprotein (LDL) levels were found.

Anahtar Kelimeler

Atherosclerosis; Grape Seed Extract; Proanthocyanidin; Simvastatin; Silymarin

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Dilek Burukoğlu

Emine Sunal Bu kişi benim

Fatma Kılıç

Sema Uslu

Setenay Öner

Ayla Eker Sarıboyacı Bu kişi benim

Dilek Burukoğlu

Murat Kılıçoğlu Bu kişi benim

Yayımlanma Tarihi

30 Ocak 2012

Gönderilme Tarihi

30 Ocak 2012

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2012 Cilt: 2 Sayı: 2

IZ

https://izlik.org/JA43GZ49RX

APA

Burukoğlu, D., Sunal, E., Kılıç, F., Uslu, S., Öner, S., Eker Sarıboyacı, A., Burukoğlu, D., & Kılıçoğlu, M. (2012). GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology, 2(2), 101-117. https://izlik.org/JA43GZ49RX

AMA

1.Burukoğlu D, Sunal E, Kılıç F, vd. GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology. 2012;2(2):101-117. https://izlik.org/JA43GZ49RX

Chicago

Burukoğlu, Dilek, Emine Sunal, Fatma Kılıç, vd. 2012. “GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS”. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 2 (2): 101-17. https://izlik.org/JA43GZ49RX.

EndNote

Burukoğlu D, Sunal E, Kılıç F, Uslu S, Öner S, Eker Sarıboyacı A, Burukoğlu D, Kılıçoğlu M (01 Kasım 2012) GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 2 2 101–117.

IEEE

[1]D. Burukoğlu vd., “GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS”, Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology, c. 2, sy 2, ss. 101–117, Kas. 2012, [çevrimiçi]. Erişim adresi: https://izlik.org/JA43GZ49RX

ISNAD

Burukoğlu, Dilek - Sunal, Emine - Kılıç, Fatma - Uslu, Sema - Öner, Setenay - Eker Sarıboyacı, Ayla - Burukoğlu, Dilek - Kılıçoğlu, Murat. “GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS”. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology 2/2 (01 Kasım 2012): 101-117. https://izlik.org/JA43GZ49RX.

JAMA

1.Burukoğlu D, Sunal E, Kılıç F, Uslu S, Öner S, Eker Sarıboyacı A, Burukoğlu D, Kılıçoğlu M. GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology. 2012;2:101–117.

MLA

Burukoğlu, Dilek, vd. “GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS”. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology, c. 2, sy 2, Kasım 2012, ss. 101-17, https://izlik.org/JA43GZ49RX.

Vancouver

1.Dilek Burukoğlu, Emine Sunal, Fatma Kılıç, Sema Uslu, Setenay Öner, Ayla Eker Sarıboyacı, Dilek Burukoğlu, Murat Kılıçoğlu. GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS. Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology [Internet]. 01 Kasım 2012;2(2):101-17. Erişim adresi: https://izlik.org/JA43GZ49RX

GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS

GPSE (GRAPE SEED PROANTHOCYANIDIN EXTRACT) SIMVASTATIN AND SILYMARIN EFFECT ON HIGH CHOLESTEROL-FED ANIMALS

Öz

Anahtar Kelimeler

Yaşam Bilimleri ve Biyoteknoloji

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Birincil Dil

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