AĞIZ, DİŞ VE ÇENE PATOLOJİLERİNİN KESİN TANISINDA İMMÜNOHİSTOKİMYASAL ANALİZİN GEREKLİLİĞİ

Öz

Oral kavite ve çene-yüz bölgesinde görülen patolojilerin ayırıcı tanısı prognozu belirleme, nüks etme eğilimini yorumlama ve doğru cerrahi tedavinin uygulanabilmesi açısından önemlidir. Oral patolojilerin tanısı klinik ve radyolojik özelliklerle ilişkili olsa da, kesin tanı histopatolojik incelemeye dayanmaktadır. Bu retrospektif çalışma 2011-2017 yılları arasında Başkent Üniversitesi Ağız Diş ve Çene Cerrahisi Bölümünde tedavi görmüş hasta verilerinin histopatolojik raporları üzerinden gerçekleştirildi. Çalışmaya toplamda 579 adet odontojenik ve odotojenik olmayan kist ve tumor vakası dahil edildi. Bu örnekler kist ve tümörün tipi, yaş, cinsiyet ve immünohistokimyasal boyama dağılımı açısından analiz edildi. Kesin tanı için 20 (% 3) olguda immünhistokimyasal analiz gerektiği görüldü. Sitokeratin AE1 / AE3, S100, CD68 ve Ki-67’nin oral ve maksillofasiyal bölgedeki kist ve tümörlerin kesin tanısını koymada en çok tercih edilen immünohistokimyasal antikorlar olduğu belirlendi. Odontojenik kistlerin kesin tanısı için immunohistokimyasal analize gerek duyulmadığı belirlendi.

Anahtar Kelimeler

• odontojenik kist
• odontojenik tümör
• oral patoloji
• immünohistokimyasal analiz

The Necessity of Immunohistochemical Analysis for Definitive Diagnosis of Oral and Maxillofacial Pathologies

Öz

The differential diagnosis of pathologies in the oral cavity and jmaxillofacial region is important in determining prognosis, interpreting the tendency to relapse, and the correct surgical treatment. Although the diagnosis of oral pathologies is related to clinical and radiological features, the definitive diagnosis is based on histopathological examination. This retrospective study was performed based on histopathological reports of patients treated in Başkent University Department of Oral and Maxillofacial Surgery between 2011-2017. A total of 579 cases of odontogenic and non-odotogenic cysts and tumors were included in the study. These samples were analyzed for cyst and tumor type, age, sex and distribution of immunohistochemical staining. Immunohistochemical analysis was necessary in 20 (3%) cases for definitive diagnosis. Cytokeratin AE1 / AE3, S100, CD68 and Ki-67 were found to be the most preferred immunohistochemical antibodies for the definitive diagnosis of cysts and tumors in the oral and maxillofacial regions. Immunohistochemical analysis was not necessary for the definitive diagnosis of odontogenic cysts.

Anahtar Kelimeler

• odontogenic cyst
• odontogenic tumors
• oral pathology
• immunohitochemical analysis

Kaynakça

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