Benign prostat hiperplazisi (BPH) ve apopitozis Benign prostatic hyperplasia (BPH) and apoptosis

Yıl 2006, , 132 - 136, 01.03.2006

Talat Yurdakul Selçuk Güven

https://doi.org/10.1501/Tipfak_0000000200

Öz

Anahtar Kelimeler

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Benign prostat hiperplazisi (BPH) ve apopitozis

Öz

Apopitozis programlanmış hücre ölümü olarak tanımlanır. Prostat büyümesi ve gelişmesi, hücre ölümü ve proliferasyonu arasında denge sağlayan androjenik kontrolün etkisi altındadır. BPH’daki prostat büyümesini inceleyen çalışmalar; stroma ve epitelyal komponentler arasındaki hücre proliferasyonu ve apopitozis dengesini sağlayan moleküler mekanizmalarda oluşan bozukluğun BPH ile karakterize anormal glands büyümesinin altında yatan sebep olduğunu göstermektedir. BPH’nın medikal tedavisi, α1 adrenoreseptör (AR) blokörlerinin prostatik düz kasların relaksasyonuna bağlı veya 5α redüktaz inhibitörlerinin glandı küçültmesine bağlı etkileriyle sikayetlerin giderilmesini hedefler. Birincil etki mekanizmaları dışında, α1 adrenoreseptör (AR) blokörlerinin ve 5α redüktaz inhibitörlerinin prostat hücrelerinde apopitozisi de indükledikleri gösterilmiştir. Bu makalede BPH’nın medikal tedavisinde kullanılan ilaçlar ile apopitotik etkileri gözden geçirilmiştir.

Anahtar Kelimeler

prostat, apopitozis, medikal tedavi

Kaynakça

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