BibTex RIS Kaynak Göster

The Effects Of Antiepileptic Drugs On Serum And Hair Trace Element Levels

Yıl 2008, Cilt: 61 Sayı: 2, 73 - 76, 01.02.2008

Deniz Tekin Haydar Ali Taşdemir Recep Saraymen

https://doi.org/10.1501/Tipfak_0000000655

Öz

Anahtar Kelimeler

-

Kaynakça

  • Wallwork JC. Zinc and central ner- vous system. Prog Food Nutri Sci 1987;11:203-247.
  • Ebadi M, Wilt S, Ramaley R, et al. The role of zinc and zinc-binding proteins in regulation of glutamic acid decar- boxylase in brain. In: Evangenopou- los AE, ed. Chemical and biological aspects of vitamin B6 catalysis: Part A New York: Alan R Liss, 1984: 255-75.
  • Smith WG, Bone I. Copper, zinc and magnesium plasma levels in epilepsy. J Neurol Neurosurg Psychiatry 1982; 45:1072.
  • Kandel ER. Transmitter release. In: Principles of neuronal science. Kan- del ER, Schwartz JH, Vessel TM (edi- tors) New York: Elsevier, 194-212.
  • Pippenger CE., Meng X, Van Leste F, et al. Valproate therapy depresses GSH-Px abd SOD enzyme activity. A possible mechanism for VPA induced idiosyncratic drug toxicity. Clinical Chemistry 1989; 35:1173-1177.
  • Schott GD, Delves HT. Plasma zinc le- vels with anticonvulsant therapy. Br J Clin Pharmacol 1978; 5:279-280.
  • Barbeau A, Donaldson J. Zinc, Ta- urine and epilepsy. Arch of Neurol 1974;30: 52-58.
  • Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992; 33: 555-557.
  • Lerman- Sagie T, Statter M, Szabo G, et al. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neurophar- macol 1987; 10:80-86.
  • Ghose K, Taylor A. Hypercupremia induced by antiepileptic drugs. Hum Toxicol 1983; 2:519-529.
  • Hurd RW, Van Rinsvelt HA, Wilder BJ, et al. Selenium, zinc and copper changes in valproic acid: possible correlation to drug side effects. Ne- urology 1984; 34:1393-1395.
  • Hamed SA, Abdellah MM, El-Melegy N. Blood levels of trace elements, electrolytes, and oxidative stres/anti- oxidant systems in epileptic patients. J Pharmacol Sci 2004; 96:465-473.
  • Kuzuya T, Hasegawa T, Shimizu K, et al. Effect of and antiepileptic drugs on serum zinc, copper concentrati- ons in epileptic patients. Int J Clin Pharmacol Ther Toxicol 1993; 31:61- 65.
  • Verrotti A, Basciani F, Trotta D, et al. Serum copper, zinc, selenium, glu- tathione peroxidase and superoxide dismutase levels in epileptic child- ren before and after 1 year of sodium valproate and carbamazepine the- rapy. Epilepsy Res 2002; 48: 71-75.
  • Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with so- dium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res. 2004; 102:1-10.
  • İlhan A, Uz E, Kali S, et al. Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair? Eur J Neurology 1999; 6(6): 705- 709.
  • Altunbasak S, Biatmakoui F, Baytok V, et al. Serum and hair zinc levels in epileptic children taking valpro- ic acid. Biol Trace Elem Res 1997; 58:117-125.
  • Steidl L, Tolde I, Svomova V. Metabo- lism of magnesium and zinc in pati- ents treated with antiepileptic drugs and with magnesium lactate. Magne- sium 1987; 6: 284-295.
  • Shaw JCL. Trace elements in the fetus and young infant. Am J Dis Child 1979; 133: 1260-1264.

Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri

Yıl 2008, Cilt: 61 Sayı: 2, 73 - 76, 01.02.2008

Deniz Tekin Haydar Ali Taşdemir Recep Saraymen

https://doi.org/10.1501/Tipfak_0000000655

Öz

Amaç: Antiepileptik ilaçların serum ve saç eser element düzeylerini etkileyip etkilemediğini göstermek için epilepsi tanısı alan 40 çocuğu değerlendirdik. Gereç ve Yöntem: Serum Zn, Cu, Mg ile saç Zn düzeyleri fenobarbital veya valproik asit tedavisi başlanmadan önce ve 3 ay sonra değerlendirildi. Bulgular: Her iki tedavi ile de serum Zn düzeyleri düştü. Fenobarbital veya Valproik asit tedavisi alan epileptik hastalar karşılaştırıldığında, fenobarbital tedavisi alanlarda serum Zn düzeylerindeki düşme daha belirgindi. Sonuç: Hastalarımızın hiçbirinde Zn eksikliğine bağlı bulgular görmesek de, Fenobarbital veya Valproik asit tedavisi alan çocuklarda bu açıdan dikkatli olunmalıdır.

Anahtar Kelimeler

Antiepileptik ilaçlar epilepsi eser element düzeyleri

Kaynakça

  • Wallwork JC. Zinc and central ner- vous system. Prog Food Nutri Sci 1987;11:203-247.
  • Ebadi M, Wilt S, Ramaley R, et al. The role of zinc and zinc-binding proteins in regulation of glutamic acid decar- boxylase in brain. In: Evangenopou- los AE, ed. Chemical and biological aspects of vitamin B6 catalysis: Part A New York: Alan R Liss, 1984: 255-75.
  • Smith WG, Bone I. Copper, zinc and magnesium plasma levels in epilepsy. J Neurol Neurosurg Psychiatry 1982; 45:1072.
  • Kandel ER. Transmitter release. In: Principles of neuronal science. Kan- del ER, Schwartz JH, Vessel TM (edi- tors) New York: Elsevier, 194-212.
  • Pippenger CE., Meng X, Van Leste F, et al. Valproate therapy depresses GSH-Px abd SOD enzyme activity. A possible mechanism for VPA induced idiosyncratic drug toxicity. Clinical Chemistry 1989; 35:1173-1177.
  • Schott GD, Delves HT. Plasma zinc le- vels with anticonvulsant therapy. Br J Clin Pharmacol 1978; 5:279-280.
  • Barbeau A, Donaldson J. Zinc, Ta- urine and epilepsy. Arch of Neurol 1974;30: 52-58.
  • Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992; 33: 555-557.
  • Lerman- Sagie T, Statter M, Szabo G, et al. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neurophar- macol 1987; 10:80-86.
  • Ghose K, Taylor A. Hypercupremia induced by antiepileptic drugs. Hum Toxicol 1983; 2:519-529.
  • Hurd RW, Van Rinsvelt HA, Wilder BJ, et al. Selenium, zinc and copper changes in valproic acid: possible correlation to drug side effects. Ne- urology 1984; 34:1393-1395.
  • Hamed SA, Abdellah MM, El-Melegy N. Blood levels of trace elements, electrolytes, and oxidative stres/anti- oxidant systems in epileptic patients. J Pharmacol Sci 2004; 96:465-473.
  • Kuzuya T, Hasegawa T, Shimizu K, et al. Effect of and antiepileptic drugs on serum zinc, copper concentrati- ons in epileptic patients. Int J Clin Pharmacol Ther Toxicol 1993; 31:61- 65.
  • Verrotti A, Basciani F, Trotta D, et al. Serum copper, zinc, selenium, glu- tathione peroxidase and superoxide dismutase levels in epileptic child- ren before and after 1 year of sodium valproate and carbamazepine the- rapy. Epilepsy Res 2002; 48: 71-75.
  • Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with so- dium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res. 2004; 102:1-10.
  • İlhan A, Uz E, Kali S, et al. Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair? Eur J Neurology 1999; 6(6): 705- 709.
  • Altunbasak S, Biatmakoui F, Baytok V, et al. Serum and hair zinc levels in epileptic children taking valpro- ic acid. Biol Trace Elem Res 1997; 58:117-125.
  • Steidl L, Tolde I, Svomova V. Metabo- lism of magnesium and zinc in pati- ents treated with antiepileptic drugs and with magnesium lactate. Magne- sium 1987; 6: 284-295.
  • Shaw JCL. Trace elements in the fetus and young infant. Am J Dis Child 1979; 133: 1260-1264.
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Deniz Tekin Bu kişi benim

Haydar Ali Taşdemir Bu kişi benim

Recep Saraymen Bu kişi benim

Yayımlanma Tarihi 1 Şubat 2008
Yayımlandığı Sayı Yıl 2008 Cilt: 61 Sayı: 2

Kaynak Göster

APA Tekin, D., Taşdemir, H. A., & Saraymen, R. (2008). Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 61(2), 73-76. https://doi.org/10.1501/Tipfak_0000000655
AMA Tekin D, Taşdemir HA, Saraymen R. Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Şubat 2008;61(2):73-76. doi:10.1501/Tipfak_0000000655
Chicago Tekin, Deniz, Haydar Ali Taşdemir, ve Recep Saraymen. “Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 61, sy. 2 (Şubat 2008): 73-76. https://doi.org/10.1501/Tipfak_0000000655.
EndNote Tekin D, Taşdemir HA, Saraymen R (01 Şubat 2008) Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası 61 2 73–76.
IEEE D. Tekin, H. A. Taşdemir, ve R. Saraymen, “Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 61, sy. 2, ss. 73–76, 2008, doi: 10.1501/Tipfak_0000000655.
ISNAD Tekin, Deniz vd. “Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 61/2 (Şubat 2008), 73-76. https://doi.org/10.1501/Tipfak_0000000655.
JAMA Tekin D, Taşdemir HA, Saraymen R. Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2008;61:73–76.
MLA Tekin, Deniz vd. “Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 61, sy. 2, 2008, ss. 73-76, doi:10.1501/Tipfak_0000000655.
Vancouver Tekin D, Taşdemir HA, Saraymen R. Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2008;61(2):73-6.