Araştırma Makalesi

A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications

Cilt: 11 Sayı: 4 22 Aralık 2023
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A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications

Öz

After a short historical background and mentioning common application areas and different clinical modalities of pulsed electric fields and the phenomena such as electro permeabilization and electroporation are introduced based on the concept of the basic mechanism. Subsequently, pulse generation (PG) and the adapted modular multilevel converter (MMC) topology that is to be covered are introduced including the operating principles and very basic analysis. Finally, performance of the proposed MMC with four half bridge submodules is tested on a prototype built in laboratory. A bidirectional voltage is produced with 80 V amplitude pulsating at 100 kHz operation frequency.

Anahtar Kelimeler

Destekleyen Kurum

Pamukkale Üniversitesi

Proje Numarası

2022FEBE004

Kaynakça

  1. [1] A. Rolong, R.V. Davalos, B. Rubinsky, "History of electroporation." In Irreversible Electroporation in Clinical Practice, 2018, pp. 13-37. Springer, Cham.
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  3. [3] C. D. McCaig, A.M. Rajnicek, B. Song, M. Zhao, "Controlling cell behavior electrically: current views and future potential." Physiological Reviews, 2005, pp. 943-978.
  4. [4] F. Carpi, S. Maddio, B. Pelosi, "An unexpected mossotti: His formula at the basis of dielectrophoresis in modern molecular biology." URSI Radio Science Bulletin 2020, no: 373, 2020, pp. 83-85.
  5. [5] M.L. Yarmush, A. Golberg, G. Serša, T. Kotnik, D. Miklavčič, "Electroporation-based technologies for medicine: principles, applications, and challenges." Annu Rev Biomed Eng., vol. 16, no. 1, 2014, pp.295-320.
  6. [6] A.A. Aguilar, M.C. Ho, E. Chang, K.W. Carlson, A. Natarajan, T. Marciano, Z. Bomzon, C.B. Patel, "Permeabilizing cell membranes with electric fields." Cancers, vol. 13, no. 9, 2021, 2283.
  7. [7] X. Li, F. Yang, B. Rubinsky, "A theoretical study on the biophysical mechanisms by which tumor treating fields affect tumor cells during mitosis." IEEE Transactions on Biomedical Engineering, vol. 67, no: 9, 2020, pp. 2594-2602.
  8. [8] T. Kotnik, L. Rems, M. Tarek, D. Miklavčič, "Membrane electroporation and electropermeabilization: mechanisms and models." Annual review of biophysics, vol. 48, 2019, pp. 63-91.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Elektrik Mühendisliği

Bölüm

Araştırma Makalesi

Erken Görünüm Tarihi

25 Ocak 2024

Yayımlanma Tarihi

22 Aralık 2023

Gönderilme Tarihi

24 Mayıs 2023

Kabul Tarihi

21 Ağustos 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 11 Sayı: 4

Kaynak Göster

APA
Eski, Ö., Şahin, K., & Çetin, S. (2023). A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications. Balkan Journal of Electrical and Computer Engineering, 11(4), 373-379. https://doi.org/10.17694/bajece.1301685
AMA
1.Eski Ö, Şahin K, Çetin S. A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications. Balkan Journal of Electrical and Computer Engineering. 2023;11(4):373-379. doi:10.17694/bajece.1301685
Chicago
Eski, Övül, Kemal Şahin, ve Sevilay Çetin. 2023. “A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications”. Balkan Journal of Electrical and Computer Engineering 11 (4): 373-79. https://doi.org/10.17694/bajece.1301685.
EndNote
Eski Ö, Şahin K, Çetin S (01 Aralık 2023) A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications. Balkan Journal of Electrical and Computer Engineering 11 4 373–379.
IEEE
[1]Ö. Eski, K. Şahin, ve S. Çetin, “A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications”, Balkan Journal of Electrical and Computer Engineering, c. 11, sy 4, ss. 373–379, Ara. 2023, doi: 10.17694/bajece.1301685.
ISNAD
Eski, Övül - Şahin, Kemal - Çetin, Sevilay. “A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications”. Balkan Journal of Electrical and Computer Engineering 11/4 (01 Aralık 2023): 373-379. https://doi.org/10.17694/bajece.1301685.
JAMA
1.Eski Ö, Şahin K, Çetin S. A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications. Balkan Journal of Electrical and Computer Engineering. 2023;11:373–379.
MLA
Eski, Övül, vd. “A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications”. Balkan Journal of Electrical and Computer Engineering, c. 11, sy 4, Aralık 2023, ss. 373-9, doi:10.17694/bajece.1301685.
Vancouver
1.Övül Eski, Kemal Şahin, Sevilay Çetin. A Modular Multilevel Converter-Based Pulsed Electric Field Generator Design for Electroporation Applications. Balkan Journal of Electrical and Computer Engineering. 01 Aralık 2023;11(4):373-9. doi:10.17694/bajece.1301685

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