Ovariohisterektomi Öncesinde Köpeklerde Preoperatif Meloksikam ve Firokoksibin Uygulamasının Postoperatif Analjezi ve İnflamatuvar Belirteçler Üzerine Etkisi

Abstract

Amaç: Bu çalışmanın amacı, ovariohisterektomi (OHE) uygulanan köpeklerde meloksikam ve firokoksibin postoperatif analjezik ve anti-inflamatuvar etkilerini değerlendirmektir. Materyal ve Yöntem: Otuz sağlıklı dişi köpek rastgele üç gruba ayrıldı: 0.2 mg/kg subkutan meloksikam, 5 mg/kg oral firokoksib veya preoperatif nonsteroid anti-inflamatuar ilaç uygulanmayan kontrol grubu. Glasgow Bileşik Ağrı Ölçeği – Kısa Formu (CMPS-SF), rektal sıcaklık ve kalp atım hızı operasyon öncesinde ve postoperatif 1., 2., 3., 4. ve 24. saatlerde kaydedildi. Aynı zaman dilimlerinde kan örnekleri alınarak kortizol düzeyleri ile nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR) ve sistemik immün-inflamasyon indeksi (SII) değerlendirildi. Bulgular: CMPS-SF skorları postoperatif 1. saatte tüm gruplarda anlamlı şekilde arttı (p<0.05) ve kontrol grubunda en yüksek düzeyde gözlendi. Skorlar 4. saatte de yüksek seyretti. Kortizol düzeyleri postoperatif 1. saatte yaklaşık 4 kat, 2. saatte 5 kat, 4. saatte ise tekrar 4 kat arttı ve 24. saatte bazal düzeye döndü (p<0.05). Rektal sıcaklık ve kalp atım hızı, operasyon sonrası erken dönemdeki başlangıç düşüşünü takiben preoperatif değerlere doğru kademeli bir artış gösterdi (p<0.05). Kurtarma analjezisi üç köpeğe uygulandı: iki köpek firokoksib grubunda, bir köpek ise kontrol grubundaydı. 24. saatte NLR ve SII değerleri kontrol grubunda tedavi gruplarına göre anlamlı olarak daha yüksekti (p<0.05). Ancak, postoperatif ilk 4 saat boyunca gruplar arasında CMPS-SF skoru ve kortizol düzeyleri açısından anlamlı fark gözlenmedi. Sonuç: Meloksikam ve firokoksib, OHE sonrası 24. saatte sistemik inflamatuvar yanıtı azaltmada etkili bulunmuştur. Erken postoperatif dönemde ağrı skorları ve kortizol düzeyleri bakımından gruplar arasında anlamlı fark olmamasına rağmen, meloksikam grubunda, firokoksib grubuna kıyasla daha az ek analjezi uygulamasına ihtiyaç duyulmuştur.

Keywords

• ağrı
• firokoksib
• köpek
• meloksikam
• NLR

Administration of Preoperative Meloxicam and Firocoxib on Postoperative Analgesia and Inflammatory Markers in Dogs Undergoing Ovariohysterectomy

Abstract

Objective: The objective of this study was to evaluate the postoperative analgesic and anti-inflammatory effects of meloxicam and firocoxib in dogs undergoing ovariohysterectomy (OHE). Materials and Methods: Thirty healthy female dogs were randomly assigned to three groups: 0.2 mg/kg subcutaneous meloxicam, 5 mg/kg oral firocoxib, or no preoperative non-steroidal antiinflammatory drug (control). The Glasgow Composite Measure Pain Scale – Short Form (CMPS-SF), rectal temperature, and heart rate were recorded preoperatively and at 1, 2, 3, 4, and 24 hours postoperatively. Blood samples were collected at each time point to assess cortisol levels and calculate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). Results: CMPS-SF scores significantly increased at 1 hour postoperatively in all groups (p<0.05), with the control group showing the highest pain scores. Scores remained elevated at 4 hours. Cortisol levels increased approximately 4-fold at 1 hour, 5-fold at 2 hours, and 4-fold at 4 hours postoperatively, returning to baseline by 24 hours (p<0.05). Rectal temperature and heart rate exhibited a gradual increase toward preoperative values following an initial decrease in the early postoperative period. Rescue analgesia was required in three dogs—two in the firocoxib group and one in the control group. At 24 hours, NLR and SII were significantly higher in the control group compared to the treatment groups (p<0.05). However, no significant differences were observed between groups in CMPS-SF scores or cortisol levels during the first 4 postoperative hours. Conclusion: Both meloxicam and firocoxib were effective in reducing systemic inflammatory responses at 24 hours post-OHE. Although there were no significant differences in early postoperative pain scores or cortisol levels, meloxicam group required fewer instances of rescue analgesia compared to the firocoxib group.

Keywords

• dog
• firocoxib
• meloxicam
• NLR
• pain

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