Sıçanlarda İndometazin ile İndüklenen Mide Ülseri Üzerine Badem ve Elma Yağının Koruyucu Etkileri

Abstract

Amaç: Günümüzde geleneksel ve alternatif tedavide bitkisel yağların kullanımı önem kazanmıştır. Özellikle doymamış yağ asit bileşimi fazla olan yağların tercih edilmesi birçok araştırmaya konu olmasına neden olmuştur. Materyal ve Metot: Bu araştırmada da özellikle meyve ve kuruyemiş olarak kullanılan badem ve elma yağının koruyucu etkileri bir antienflamatuvar ilaç olan indometazin indüklemeli ülser modelinde belirlenmiştir. Deney grupları 0.5 ve 1 ml/kg dozda olacak şekilde badem ve elma yağı, pozitif kontrol famotidin grubu, negatif grup olarak da İND ve en son grup sağlıklı olacak şekilde belirlenmiştir. 24 saatlik açlık sonunda deney hayvanlarının mide dokularında biyokimyasal parametreler antiülser etkiyi ifade etmiştir. Bulgular: Uygulanan İND ile artan LPO seviyeleri, KAT, GR ve MPx enzim aktiviteleri önemli oransa yağlar tarafından azaltılmıştır. Aynı zamanda uygulanan İND ile azalan GSH seviyelerini de badem ve elma yağı önemli oranda arttırmıştır.

Keywords

• elma yağı
• badem yağı
• indometazin
• ülser
• lipid peroksidasyonu
• elma yağı, badem yağı, indometazin, ülser, lipid peroksidasyonu

The protective Effects of Almond and Apple Oil on Indomethacin-Induced Stomach Ulcer in Rats

Abstract

Objective: Today, the use of vegetable oils in traditional and alternative therapy has gained importance. Especially the preference of oils with high unsaturated fatty acid composition has caused many researches. Materials and Methods: In this study, the protective effects of almond and apple oil, especially used as fruits and nuts, were determined in the model of indomethacin-induced ulcer, an anti-inflammatory drug. The experimental groups were determined as 0.5 and 1 ml / kg of almond and apple oil, the positive control famotidine group, the negative group as IND and the last group as healthy. Results: Biochemical parameters in the stomach tissues of experimental animals at the end of 24 hours of fasting expressed the antiulcer effect. Increased LPO levels, CAT, GR and MPx enzyme activities with the applied INDO were significantly reduced by the oils. At the same time, almond and apple oil significantly increased the GSH levels, which decreased with the application of IND.

Keywords

• almond oil
• apple oil
• indomethacin
• ulcer
• lipid peroxidation

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