ORTOMOLEKÜLER TIP YAKLAŞIMIYLA MAGNEZYUM TAKVİYELERİ

Öz

Magnezyum, bedendeki 300'den fazla enzimatik reaksiyonda kofaktör olarak rol oynayan çeşitli gıdalarda ve dünyanın doğal oluşumlarında bulunan bir mineraldir. Protein ve nükleik asit sentezinde, hücre yapısında ve siklusunda, mitokondri bütünlüğünde, hücre membran stabilitesinde, iyon transportunda çok önemli rol oynar. İnsan bedeninde 25 gram magnezyum vardır ve bunun %99'luk kısmı kıkırdak gibi yumuşak dokularda ve kemikte bulunur, kanda tespit edilen çok küçük bir kısmıdır. Serum magnezyum seviyesinde hafif bir düşüş bile magnezyumun rol aldığı enzimatik süreçlerde ve dolayısıyla bunlara bağlı fonksiyonlarda bozulmaya neden olur. Magnezyumun günlük alınması gereken minumum miktarı erkeklerde 400 mg, kadınlarda 310 mg'dır. Doğal magnezyum kaynakları koyu yeşil yapraklı sebzeler, tahıl ürünleri, kuruyemişler, bazı meyvelerdir. Toprağın yanlış ziraii uygulamalar sonucunda yetersiz magnezyum içermesi ve modern diyetlerde aşırı işlenmiş gıdaların çok fazla kullanılması tüketilen gıdaların yeterince magnezyum içermesine engel oluşturur. Bağırsak parazitleri, kandida ve vücuttaki microbiotayı oluşturan diğer bakteri ve mantarlar toplam alınan magnezyumun büyük bir kısmını kullanırlar, bunun için de bedenle rekabete girerler. Dolayısıyla bedenin magnezyuma bağlı hayati fonksiyonlarını yerine getirebilmesi için takviye kullanması gerekebilir. Bu takviyelerin en yaygın kullanılanları Mg Glisinat, Mg Taurate, Mg Threonat, Mg Sitrat'tır

Anahtar Kelimeler

• Magnezyum, ortomoleküler tıp, besin takviyesi, tamamlayıcı tıp

MAGNESIUM SUPPLEMENTS BY ORTHO MOLECULAR MEDICINE APPROACH

Öz

Magnesium is a mineral found in various foods and in the natural formations of the world that act as cofactors in more than 300 enzymatic reactions on the body. It plays a very important role in protein and nucleic acid synthesis, cell structure and cycle, mitochondrial integrity, cell membrane stability, ion transport. The human body has 25 grams of magnesium, 99% of which is found in soft tissues such as cartilage and bones. A small fraction of magnesium can be detected in the blood. Even a slight decrease in the magnesium level causes defects in enzymatic processes involving magnesium, The minimum amount of magnesium to be taken daily is 400 mg for males and 310 mg for females. Natural magnesium sources include dark green leafy vegetables, cereal products, nuts, some fruits, etc. As a result of inadequate agricultural practices in the soil and the excessive use of over-processed foods in modern diets is an obstacle to consuming enough magnesium from foods. The intestinal parasites, candida and the other bacteria and fungi that make up microbiota in the body use a large part of the total amount of magnesium, and for that, they enter the competition with the body. Thus necessity to use magnesium supplements to fulfill the vital functions of the body depending on magnesium may arise. The most commonly used supplements are Mg Glycinate, Mg Taurate, Mg Threonate, Mg Citrate

Anahtar Kelimeler

• Magnesium, orthomolecular medicine, food suplements, comlemantary medicine

Kaynakça

1. Bo S, Pisu E. Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes. Curr Opin Lipidol. 2008 Feb;19(1):50-6.
2. Champagne CM. Magnesium in hypertension, cardiovascular disease, metabolic syndrome, and other conditions: a review. Nutr Clin Pract. 2008 Apr-May;23(2):142-51.
3. Chiuve SE, Korngold EC, Januzzi JL, Gantzer ML, Albert CM. Plasma and dietary magnesium and risk of sudden cardiac death in women. Am J Clin Nutr. 2011;93(2):253-60.
4. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment.Med Hypotheses. 2006;67(2):362-70.
5. Johnson S. The multifaceted and widespread pathology of magnesium deficiency. Med Hypotheses. 2001;56(2):163-170.
6. Moulin DE. Systemic drug treatment for chronic musculoskeletal pain. Clin J Pain. 2001;17(4 Suppl):S86-S93.
7. Witkowski M, Hubert J, Mazur A. Methods of assessment of magnesium status in humans: a systematic review. Magnesium Res 2011;24:163-80. [PubMed abstract]
8. Lindberg JS, Zobitz MM, Poindexter JR, Pak CY. Magnesium bioavaila- bility from magnesium citrate and magnesium oxide. J Am Coll Nutr 1990;9:48-55. [PubMed abstract]

9. Walker AF, Marakis G, Christie S, Byng M. Mg citrate found more bioava- ilable than other Mg preparations in a randomized, double-blind study. Mag Res 2003;16:183-91. [PubMed abstract]
10. McKee JA, Brewer RP, Macy GE, et al. Analysis of the brain bioavailabi- lity of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnese- mia. Crit Care Med. 2005 Mar;33(3):661-6.
11. Abumaria N, Yin B, Zhang L, Zhao L, Liu G. Enhancement of cognitive control of emotions by elevated brain magnesium leads to anti-depres- sants like effect. Poster presentation #549. Society for Neuroscience 2009 Meeting. October 20, 2009. Chicago, IL
12. Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and me- mory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77. 9. Barbagallo M, Belvedere M, Dominguez LJ. Magnesium homeostasis and aging. Magnes Res. 2009 Dec;22(4):235-46.
13. Durlach, J. Importance and clinical forms of chronic primary magnesium deficiency in human beings. Magnesium Res. 2001; 14: 83–84
14. Zhao L, Lou JS, Kang Y. Taurine-magnesium coordination compound at- tenuates hypoxia/reoxygenation induced Ion channel dysfunction in rat ventricular myocytes. Drug Res (Stuttg). 2013 Mar 13.
15. Rude RK, Singer FR, Gruber HE. Skeletal and hormonal effects of magne- sium deficiency. J Am Coll Nutr. 2009 Apr;28(2):131-41.
16. Hoane MR, Gilbert DR, Barbre AB, Harrison SA. Magnesium dietary ma- nipulation and recovery of function following controlled cortical damage in the rat. Magnes Res. 2008 Mar;21(1):29-37.