Cell-free fetal DNA and RNA circulating in maternal blood: review, part I

Yıl 2010, Cilt: 1 Sayı: 3, 52 - 60, 05.04.2013

Ali Çetin

https://doi.org/10.12808/bcs.v1i3.11

Öz

Abstract

This review evaluates the scientific and clinical status of the use of circulating cell-free fetal nucleic acid technology for non-invasive prenatal diagnosis, a rapidly developing and dynamic field. After the landmark discovery of cell-free fetal DNA in maternal blood during pregnancy was made more than a decade ago, it was recognized that the cell-free fetal DNA represents only a small fraction of the total cell-free DNA in the maternal circulation during pregnancy. It is known that it can be reliably detected from 5 weeks gestation and is totally cleared within a few hours of birth. The promise of that breakthrough is now being realized as the technology is translated into clinical practice for the non-invasive prenatal diagnosis.

Keywords: Cell-free fetal nucleic acids, DNA, RNA, pregnancy, non-invasive prenatal diagnosis

Özet

Anne kanında serbest dolaşan hücre dışı fetal DNA ve RNA: derleme, bölüm 1

Bu derleme hızlı gelişen ve dinamik bir alan olan non-invaziv prenatal tanı için dolaşımda bulunan hücre dışı fetal nükleik asitlerin kullanımının bilimsel ve klinik durumunu içerir. Gebelikte anne kanında hücre dışı fetal DNA'nın bulunmasının üzerinde on yıldan fazla süre geçtikten sonra, gebelikte anne kanında bulunan serbest DNA'nın küçük bir kısmını oluşturduğu görüldü. Gebeliğin beşinci haftasından sonra ölçülebilmektedir ve doğumdan kısa süre sonra kandan kaybolmaktadır. Bu ilerlemenin sayesinde non-invaziv prenatal tanı için bu teknoloji klinik pratiğe aktarılmaya çalışılmaktadır.

Anahtar sözcükler: Hücre dışı fetal nükleik asitler, DNA, RNA, gebelik, non-invasiv prenatal tanı

Anahtar Kelimeler

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Kaynakça

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