Place of neopterin level in the differential diagnosis of tuberculosis pleurisy

Yıl 2013, Cilt: 2 Sayı: 2, 65 - 70, 08.09.2013

Faysal Duksal , İsa Döngel , Fatma Duksal Armağan Hazar

https://doi.org/10.12808/bcs.v2i2.27

Öz

Absract

Aim. Tuberculous pleurisy, a form of tuberculosis, may be confused with many other diseases.  This study was designed to assess the diagnostic value of pleural fluid neopterin levels in tuberculous pleurisy. Methods. Total 57 patients (30 patients with tuberculosis pleurisy, 17 cases with malignant pleural effusion, 10 cases of pleural effusion due to congestive heart failure) were studied. The measurement of neopterin levels was conducted by the enzymeimmunassay method and Trinity-Biotech XL fully automatic ELISA kit device and neopterin IBL kit. Results. The neopterin levels in pleural fluid due to tuberculosis were significantly higher than that of both malignancy and congestive heart failure (p<0.001). The neopterin levels of patients with congestive heart failure and malignancy were found as similar (p=0.920). There was no significant difference in the neopterin levels with regard to age and sex (p>0.05). Conclusions. Tuberculous pleurisy increases neopterin levels of pleural fluid as compared with pleural fluid related to malignancy and congestive heart failure. It is thought that neopterin level in the pleural fluid may be used in the diagnosis of  tuberculosis.

Keywords: Neopterin, pleural effusion, tuberculous pleurisy

Özet

Amaç. Tüberkülozun bir tipi olan tüberküloz plörezi birçok hastalık ile karıştırılabilir. Bu çalışma tüberküloz plörezide plevral sıvıda neopterin düzeylerini değerlendirmek amacı ile oluşturulmuştur. Yöntem. Toplam 57 hasta (30 tüberküloz plörezi, 17 malign plevral efüzyon ve 10 konjestif kalp yetmezliği olgusu) çalışmaya alındı. Neopterin düzeylerinin ölçümü enzimimmünoassay yöntemi ve Trinity-Biotech XL tam otomatik ELISA kit aleti ve neopterin IBL kiti ile gerçekleştirildi. Bulgular. Tüberküloza bağlı oluşan plevral sıvıdaki neopterin düzeyi malignite ve konjestif kalp yetmezliğine bağlı olanlarınkine göre anlamlı derecede yüksek bulundu (p<0,001). Konjestif kalp yetmezliği ve maligniteye bağlı plevral sıvıların neopterin düzeyleri benzer bulundu (p=0,920). Yaş ve cinsiyete göre neopterin düzeylerinde anlamlı değişiklik bulunmadı (p>0,05). Sonuçlar. Tüberküloz plörezi malignite ve konjestif kalp yetmezliğine bağlı plevral sıvılara göre daha fazla neopterin düzeyine sahiptir. Plevral sıvıda neopterin ölçümünün tüberküloz tanısında kullanılması olasıdır.

Anahtar sözcükler: Neopterin, plevral efüzyon, tüberküloz plörezi

Anahtar Kelimeler

Neopterin; pleural effusion; tuberculous pleurisy

Kaynakça

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