The use of growth hormone in in vitro fertilization

Yıl 2013, Cilt: 2 Sayı: 3, 123 - 127, 04.03.2014

Kübra Boynukalın Tolga Güler

https://doi.org/10.12808/bcs.v2i3.35

Öz

Abstract

Growth hormone (GH) is a 191 amino acid, single chain polypeptide hormone, produced, stored and secreted by somatotroph cells in the anterior pituitary gland. Normal fertility does not seem to require a normal GH axis. Aim of this review is to evaluate GH medication for controlled ovarian hyperstimulation (COH) protocols in IVF. All of the randomized controlled trials (RCTs) in the literature about this topic are small numbered. There is currently enough evidence to be moderately confident that adjuvant GH treatment undergoing IVF/ICSI treatment results in higher delivery rates but caution is required. Fertility specialists must design larger RCTs that may detect the effect of GH in IVF/ICSI treatment clearly.

Keywords: Growth hormone, controlled ovarian hyperstimulation

Özet

Büyüme hormonu (BH), ön hipofiz bezindeki somatotrof hücrelerce üretilen, depolanan ve salgılanan, 191 amino asitlik tek zincirli polipeptit bir hormondur. Normal fertilite için normal bir BH aksı şart değildir. Bu derlemede kontrollü ovaryan hiperstimülasyon sikluslarında BH kullanımının yeri irdelenmiştir. Literatürde bu konu işe ilgili randomize kontrollü çalışmalar küçük örneklem sayısı içerirler. Ancak, IVF sikluslarında adjuvan BH kullanımının daha yüksek doğum oranları ile ilişkili olduğunu söylemek için yeterli kanıt mevcuttur. İnfertilite uzmanları BH'nın IVF tedavisi üzerindeki etkisini daha net açıklayabilmek amacıyla daha büyük çapta randomize kontrollü çalışmalar dizayn etmelilerdir.

Anahtar sözcükler: Büyüme hormonu, kontrollü ovaryan hiperstimülasyon

Anahtar Kelimeler

Growth hormone, controlled ovarian hyperstimulation

Kaynakça

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