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Biomedical Image Super-Resolution Using SRGAN: Enhancing Diagnostic Accuracy

Year 2025, Volume: 14 Issue: 1, 198 - 212, 26.03.2025
https://doi.org/10.17798/bitlisfen.1565824

Abstract

The super-resolution method, which has gained significant popularity today, aims to obtain high-resolution images from low-resolution ones, enhancing image quality and making details clearer. This technique allows for more detailed analysis of images, providing significant advantages in medical imaging, restoration of old photographs, and the analysis of security cameras. In medical imaging, super-resolution contributes to more accurate diagnosis of diseases by clarifying low-resolution MRI, CT, and ultrasound images. Similarly, in the restoration of old photographs, improving blurred visuals allows for the preservation and renewal of historically significant images. In the field of security, enhancing images obtained from low-resolution surveillance cameras makes it easier to identify suspects and allows for a more detailed analysis of events, playing a critical role in solving crimes. In recent years, deep learning-based approaches have made significant progress in the field of super-resolution. Notably, Convolutional Neural Networks (CNN) have achieved great success in solving these problems. However, one of the most remarkable developments in super-resolution is the SRGAN model, based on Generative Adversarial Networks (GAN). SRGAN has surpassed traditional methods by more effectively improving image quality. In this study, the SRGAN model was trained on three different biomedical datasets, achieving PSNR values of 31 and SSIM values of up to 94%. These results demonstrate the potential of super-resolution in enhancing biomedical imaging, offering clearer images for more accurate disease diagnosis, thereby improving the precision of medical analyses. Moreover, given that these developments can also be applied in fields such as security and restoration, the importance of super-resolution techniques across different disciplines is increasingly recognized.

Ethical Statement

The study is complied with research and publication ethics.

References

  • P. Chopade and P. Patil, "Image super resolution scheme based on wavelet transform and its performance analysis," in International Conference on Computing, Communication & Automation, 2015, pp. 1182-1186: IEEE.
  • L. Yue, H. Shen, J. Li, Q. Yuan, H. Zhang, and L. Zhang, "Image super-resolution: The techniques, applications, and future," Signal processing, vol. 128, pp. 389-408, 2016.
  • X. Hou, T. Liu, S. Wang, and L. Zhang, "Image Quality Improve by Super Resolution Generative Adversarial Networks," in 2021 2nd International Conference on Intelligent Computing and Human-Computer Interaction (ICHCI), 2021, pp. 117-121: IEEE.
  • J. Yang and T. Huang, "Image super-resolution: Historical overview and future challenges," in Super-resolution imaging: CRC Press, 2017, pp. 1-34.
  • G. Zamzmi, S. Rajaraman, and S. Antani, "Accelerating super-resolution and visual task analysis in medical images," Applied Sciences, vol. 10, no. 12, p. 4282, 2020.
  • A. Aakerberg, K. Nasrollahi, and T. B. Moeslund, "Real‐world super‐resolution of face‐images from surveillance cameras," IET Image Processing, vol. 16, no. 2, pp. 442-452, 2022.
  • T. An, X. Zhang, C. Huo, B. Xue, L. Wang, and C. Pan, "TR-MISR: Multiimage super-resolution based on feature fusion with transformers," IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, vol. 15, pp. 1373-1388, 2022.
  • F. Salvetti, V. Mazzia, A. Khaliq, and M. Chiaberge, "Multi-image super resolution of remotely sensed images using residual attention deep neural networks," Remote Sensing, vol. 12, no. 14, p. 2207, 2020.
  • S. M. A. Bashir, Y. Wang, M. Khan, and Y. Niu, "A comprehensive review of deep learning-based single image super-resolution," PeerJ Computer Science, vol. 7, p. e621, 2021.
  • P. Wang, B. Bayram, and E. Sertel, "A comprehensive review on deep learning based remote sensing image super-resolution methods," Earth-Science Reviews, vol. 232, p. 104110, 2022.
  • C. Dong, C. C. Loy, K. He, and X. Tang, "Image super-resolution using deep convolutional networks," IEEE transactions on pattern analysis and machine intelligence, vol. 38, no. 2, pp. 295-307, 2015.
  • J. Kim, J. K. Lee, and K. M. Lee, "Accurate image super-resolution using very deep convolutional networks," in Proceedings of the IEEE conference on computer vision and pattern recognition, 2016, pp. 1646-1654.
  • B. Lim, S. Son, H. Kim, S. Nah, and K. Mu Lee, "Enhanced deep residual networks for single image super-resolution," in Proceedings of the IEEE conference on computer vision and pattern recognition workshops, 2017, pp. 136-144.
  • Y. Zhang, Y. Tian, Y. Kong, B. Zhong, and Y. Fu, "Residual dense network for image super-resolution," in Proceedings of the IEEE conference on computer vision and pattern recognition, 2018, pp. 2472-2481.
  • L. Xu, J. S. Ren, C. Liu, and J. Jia, "Deep convolutional neural network for image deconvolution," Advances in neural information processing systems, vol. 27, 2014.
  • K. Zhang, W. Zuo, Y. Chen, D. Meng, and L. Zhang, "Beyond a gaussian denoiser: Residual learning of deep cnn for image denoising," IEEE transactions on image processing, vol. 26, no. 7, pp. 3142-3155, 2017.
  • T. Y. Timothy, D. Ma, J. Cole, M. J. Ju, M. F. Beg, and M. V. Sarunic, "Spectral bandwidth recovery of optical coherence tomography images using deep learning," in 2021 12th International Symposium on Image and Signal Processing and Analysis (ISPA), 2021, pp. 67-71: IEEE.
  • (10.10.2024). The International Skin Imaging Collaboration. Available: https://www.isic-archive.com/
  • M. G. Mehrad Aria, Davood Bashash, Hassan Abolghasemi, and F. A. a. A. Hossein, "Acute Lymphoblastic Leukemia (ALL) image datase," ed, 2021.
  • C. Hernandez-Matas, X. Zabulis, A. Triantafyllou, P. Anyfanti, S. Douma, and A. A. Argyros, "FIRE: fundus image registration dataset," Modeling and Artificial Intelligence in Ophthalmology, vol. 1, no. 4, pp. 16-28, 2017.
  • R. Krithiga and P. Geetha, "Breast cancer detection, segmentation and classification on histopathology images analysis: a systematic review," Archives of Computational Methods in Engineering, vol. 28, no. 4, pp. 2607-2619, 2021.
  • C. Mondal et al., "Ensemble of convolutional neural networks to diagnose acute lymphoblastic leukemia from microscopic images," Informatics in Medicine Unlocked, vol. 27, p. 100794, 2021.
  • I. Goodfellow et al., "Generative adversarial nets," Advances in neural information processing systems, vol. 27, 2014.
  • I. Goodfellow et al., "Generative adversarial networks," Communications of the ACM, vol. 63, no. 11, pp. 139-144, 2020.
  • M. Arjovsky, S. Chintala, and L. Bottou, "Wasserstein generative adversarial networks," in International conference on machine learning, 2017, pp. 214-223: PMLR.
  • C. Ledig et al., "Photo-realistic single image super-resolution using a generative adversarial network," in Proceedings of the IEEE conference on computer vision and pattern recognition, 2017, pp. 4681-4690.
  • X. Zhu, L. Zhang, L. Zhang, X. Liu, Y. Shen, and S. Zhao, "GAN‐Based Image Super‐Resolution with a Novel Quality Loss," Mathematical Problems in Engineering, vol. 2020, no. 1, p. 5217429, 2020.
  • J. Korhonen and J. You, "Peak signal-to-noise ratio revisited: Is simple beautiful?," in 2012 Fourth international workshop on quality of multimedia experience, 2012, pp. 37-38: IEEE.
  • Y.-K. Chen, F.-C. Cheng, and P. Tsai, "A gray-level clustering reduction algorithm with the least PSNR," Expert Systems with Applications, vol. 38, no. 8, pp. 10183-10187, 2011.
  • M.-H. Horng and R.-J. Liou, "Multilevel minimum cross entropy threshold selection based on the firefly algorithm," Expert Systems with Applications, vol. 38, no. 12, pp. 14805-14811, 2011.
  • S. Arora, J. Acharya, A. Verma, and P. K. Panigrahi, "Multilevel thresholding for image segmentation through a fast statistical recursive algorithm," Pattern Recognition Letters, vol. 29, no. 2, pp. 119-125, 2008.
  • Z. Wang, A. C. Bovik, H. R. Sheikh, and E. P. Simoncelli, "Image quality assessment: from error visibility to structural similarity," IEEE transactions on image processing, vol. 13, no. 4, pp. 600-612, 2004.
  • D. R. I. M. Setiadi, "PSNR vs SSIM: imperceptibility quality assessment for image steganography," Multimedia Tools and Applications, vol. 80, no. 6, pp. 8423-8444, 2021.
  • U. Sara, M. Akter, and M. S. Uddin, "Image quality assessment through FSIM, SSIM, MSE and PSNR—a comparative study," Journal of Computer and Communications, vol. 7, no. 3, pp. 8-18, 2019.
Year 2025, Volume: 14 Issue: 1, 198 - 212, 26.03.2025
https://doi.org/10.17798/bitlisfen.1565824

Abstract

References

  • P. Chopade and P. Patil, "Image super resolution scheme based on wavelet transform and its performance analysis," in International Conference on Computing, Communication & Automation, 2015, pp. 1182-1186: IEEE.
  • L. Yue, H. Shen, J. Li, Q. Yuan, H. Zhang, and L. Zhang, "Image super-resolution: The techniques, applications, and future," Signal processing, vol. 128, pp. 389-408, 2016.
  • X. Hou, T. Liu, S. Wang, and L. Zhang, "Image Quality Improve by Super Resolution Generative Adversarial Networks," in 2021 2nd International Conference on Intelligent Computing and Human-Computer Interaction (ICHCI), 2021, pp. 117-121: IEEE.
  • J. Yang and T. Huang, "Image super-resolution: Historical overview and future challenges," in Super-resolution imaging: CRC Press, 2017, pp. 1-34.
  • G. Zamzmi, S. Rajaraman, and S. Antani, "Accelerating super-resolution and visual task analysis in medical images," Applied Sciences, vol. 10, no. 12, p. 4282, 2020.
  • A. Aakerberg, K. Nasrollahi, and T. B. Moeslund, "Real‐world super‐resolution of face‐images from surveillance cameras," IET Image Processing, vol. 16, no. 2, pp. 442-452, 2022.
  • T. An, X. Zhang, C. Huo, B. Xue, L. Wang, and C. Pan, "TR-MISR: Multiimage super-resolution based on feature fusion with transformers," IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, vol. 15, pp. 1373-1388, 2022.
  • F. Salvetti, V. Mazzia, A. Khaliq, and M. Chiaberge, "Multi-image super resolution of remotely sensed images using residual attention deep neural networks," Remote Sensing, vol. 12, no. 14, p. 2207, 2020.
  • S. M. A. Bashir, Y. Wang, M. Khan, and Y. Niu, "A comprehensive review of deep learning-based single image super-resolution," PeerJ Computer Science, vol. 7, p. e621, 2021.
  • P. Wang, B. Bayram, and E. Sertel, "A comprehensive review on deep learning based remote sensing image super-resolution methods," Earth-Science Reviews, vol. 232, p. 104110, 2022.
  • C. Dong, C. C. Loy, K. He, and X. Tang, "Image super-resolution using deep convolutional networks," IEEE transactions on pattern analysis and machine intelligence, vol. 38, no. 2, pp. 295-307, 2015.
  • J. Kim, J. K. Lee, and K. M. Lee, "Accurate image super-resolution using very deep convolutional networks," in Proceedings of the IEEE conference on computer vision and pattern recognition, 2016, pp. 1646-1654.
  • B. Lim, S. Son, H. Kim, S. Nah, and K. Mu Lee, "Enhanced deep residual networks for single image super-resolution," in Proceedings of the IEEE conference on computer vision and pattern recognition workshops, 2017, pp. 136-144.
  • Y. Zhang, Y. Tian, Y. Kong, B. Zhong, and Y. Fu, "Residual dense network for image super-resolution," in Proceedings of the IEEE conference on computer vision and pattern recognition, 2018, pp. 2472-2481.
  • L. Xu, J. S. Ren, C. Liu, and J. Jia, "Deep convolutional neural network for image deconvolution," Advances in neural information processing systems, vol. 27, 2014.
  • K. Zhang, W. Zuo, Y. Chen, D. Meng, and L. Zhang, "Beyond a gaussian denoiser: Residual learning of deep cnn for image denoising," IEEE transactions on image processing, vol. 26, no. 7, pp. 3142-3155, 2017.
  • T. Y. Timothy, D. Ma, J. Cole, M. J. Ju, M. F. Beg, and M. V. Sarunic, "Spectral bandwidth recovery of optical coherence tomography images using deep learning," in 2021 12th International Symposium on Image and Signal Processing and Analysis (ISPA), 2021, pp. 67-71: IEEE.
  • (10.10.2024). The International Skin Imaging Collaboration. Available: https://www.isic-archive.com/
  • M. G. Mehrad Aria, Davood Bashash, Hassan Abolghasemi, and F. A. a. A. Hossein, "Acute Lymphoblastic Leukemia (ALL) image datase," ed, 2021.
  • C. Hernandez-Matas, X. Zabulis, A. Triantafyllou, P. Anyfanti, S. Douma, and A. A. Argyros, "FIRE: fundus image registration dataset," Modeling and Artificial Intelligence in Ophthalmology, vol. 1, no. 4, pp. 16-28, 2017.
  • R. Krithiga and P. Geetha, "Breast cancer detection, segmentation and classification on histopathology images analysis: a systematic review," Archives of Computational Methods in Engineering, vol. 28, no. 4, pp. 2607-2619, 2021.
  • C. Mondal et al., "Ensemble of convolutional neural networks to diagnose acute lymphoblastic leukemia from microscopic images," Informatics in Medicine Unlocked, vol. 27, p. 100794, 2021.
  • I. Goodfellow et al., "Generative adversarial nets," Advances in neural information processing systems, vol. 27, 2014.
  • I. Goodfellow et al., "Generative adversarial networks," Communications of the ACM, vol. 63, no. 11, pp. 139-144, 2020.
  • M. Arjovsky, S. Chintala, and L. Bottou, "Wasserstein generative adversarial networks," in International conference on machine learning, 2017, pp. 214-223: PMLR.
  • C. Ledig et al., "Photo-realistic single image super-resolution using a generative adversarial network," in Proceedings of the IEEE conference on computer vision and pattern recognition, 2017, pp. 4681-4690.
  • X. Zhu, L. Zhang, L. Zhang, X. Liu, Y. Shen, and S. Zhao, "GAN‐Based Image Super‐Resolution with a Novel Quality Loss," Mathematical Problems in Engineering, vol. 2020, no. 1, p. 5217429, 2020.
  • J. Korhonen and J. You, "Peak signal-to-noise ratio revisited: Is simple beautiful?," in 2012 Fourth international workshop on quality of multimedia experience, 2012, pp. 37-38: IEEE.
  • Y.-K. Chen, F.-C. Cheng, and P. Tsai, "A gray-level clustering reduction algorithm with the least PSNR," Expert Systems with Applications, vol. 38, no. 8, pp. 10183-10187, 2011.
  • M.-H. Horng and R.-J. Liou, "Multilevel minimum cross entropy threshold selection based on the firefly algorithm," Expert Systems with Applications, vol. 38, no. 12, pp. 14805-14811, 2011.
  • S. Arora, J. Acharya, A. Verma, and P. K. Panigrahi, "Multilevel thresholding for image segmentation through a fast statistical recursive algorithm," Pattern Recognition Letters, vol. 29, no. 2, pp. 119-125, 2008.
  • Z. Wang, A. C. Bovik, H. R. Sheikh, and E. P. Simoncelli, "Image quality assessment: from error visibility to structural similarity," IEEE transactions on image processing, vol. 13, no. 4, pp. 600-612, 2004.
  • D. R. I. M. Setiadi, "PSNR vs SSIM: imperceptibility quality assessment for image steganography," Multimedia Tools and Applications, vol. 80, no. 6, pp. 8423-8444, 2021.
  • U. Sara, M. Akter, and M. S. Uddin, "Image quality assessment through FSIM, SSIM, MSE and PSNR—a comparative study," Journal of Computer and Communications, vol. 7, no. 3, pp. 8-18, 2019.
There are 34 citations in total.

Details

Primary Language English
Subjects Artificial Intelligence (Other)
Journal Section Research Article
Authors

Zübeyr Güngür 0009-0000-0843-6333

İbrahim Ayaz 0000-0003-3519-1882

Vedat Tümen 0000-0003-0271-216X

Publication Date March 26, 2025
Submission Date October 12, 2024
Acceptance Date November 19, 2024
Published in Issue Year 2025 Volume: 14 Issue: 1

Cite

IEEE Z. Güngür, İ. Ayaz, and V. Tümen, “Biomedical Image Super-Resolution Using SRGAN: Enhancing Diagnostic Accuracy”, Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, vol. 14, no. 1, pp. 198–212, 2025, doi: 10.17798/bitlisfen.1565824.

Bitlis Eren University
Journal of Science Editor
Bitlis Eren University Graduate Institute
Bes Minare Mah. Ahmet Eren Bulvari, Merkez Kampus, 13000 BITLIS