Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method

Murat Çavuş

EN

Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method

Öz

Membrane proteins such as ion channels, transporters and receptors are among the biologically important proteins. Because membrane proteins allow cells to communicate with their environment. Therefore, membrane proteins are targets for almost all drugs. It is also of scientific interest that membrane proteins play an important role in the control of the life process. Recent developments in experimental and computational sciences have further increased the interest in membrane proteins. The milestone development in this area is the obtaining of the crystal structure of membrane proteins. The crystal structure of the voltage-gated bacterial Nav channel was obtained in 2011 by Payandeh et al. Voltage-gated sodium channels are very important as they initiate the action potential. In this study, the Crooks fluctuation method, which was developed for the calculation of free energy in unbalanced systems, was applied for voltage-gated sodium channels, which is a complex biological system. The results were compared with other calculation methods in the literature.

Anahtar Kelimeler

Crooks fluctuation method, Ion channels, Sodium channel, Molecular modelling

Destekleyen Kurum

Management Unit of Scientific Research Project of Yozgat Bozok University

Proje Numarası

2014EF/A104

Teşekkür

This work has supported the Management Unit of Scientific Research Project of Yozgat Bozok University under Project Nos. 2014EF/A104.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Atomik, Moleküler ve Optik Fizik

Bölüm

Araştırma Makalesi

Yazarlar

Murat Çavuş ^*
0000-0002-2341-6485
Türkiye

Yayımlanma Tarihi

30 Mayıs 2023

Gönderilme Tarihi

26 Nisan 2023

Kabul Tarihi

2 Mayıs 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 1 Sayı: 1

IZ

https://izlik.org/JA47LN29HE

APA

Çavuş, M. (2023). Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method. Bozok Journal of Science, 1(1), 23-33. https://izlik.org/JA47LN29HE

AMA

1.Çavuş M. Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method. BJS. 2023;1(1):23-33. https://izlik.org/JA47LN29HE

Chicago

Çavuş, Murat. 2023. “Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method”. Bozok Journal of Science 1 (1): 23-33. https://izlik.org/JA47LN29HE.

EndNote

Çavuş M (01 Mayıs 2023) Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method. Bozok Journal of Science 1 1 23–33.

IEEE

[1]M. Çavuş, “Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method”, BJS, c. 1, sy 1, ss. 23–33, May. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA47LN29HE

ISNAD

Çavuş, Murat. “Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method”. Bozok Journal of Science 1/1 (01 Mayıs 2023): 23-33. https://izlik.org/JA47LN29HE.

JAMA

1.Çavuş M. Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method. BJS. 2023;1:23–33.

MLA

Çavuş, Murat. “Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method”. Bozok Journal of Science, c. 1, sy 1, Mayıs 2023, ss. 23-33, https://izlik.org/JA47LN29HE.

Vancouver

1.Murat Çavuş. Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method. BJS [Internet]. 01 Mayıs 2023;1(1):23-3. Erişim adresi: https://izlik.org/JA47LN29HE

Öz

Free Energy Calculation for NavAb Channel Using the Crooks Fluctuation Method

Öz

Anahtar Kelimeler

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

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