Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol

Mohammed Adnan Jado; Yusuf Kalender

doi:10.70500/bjs.1498720

EN

Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol

Öz

Imidacloprid is one of the insecticides in the neonicotinoid group. Resveratrol and berberine are powerful antioxidants known to alleviate the adverse effects of toxicity caused by oxidative stress. The aim of this study was to investigate the potential toxic effects of imidacloprid in the small intestinal tissues of rats and the protective effects of berberine and resveratrol against these effects. In the study, rats were divided into 7 groups. The groups were as follows: control group, resveratrol (20 mg/kg), berberine (100 mg/kg), imidacloprid (9 mg/kg.), imidacloprid plus resveratrol, imidacloprid plus berberine, imidacloprid plus resveratrol plus berberine. Test compounds were administered to rats by gavage for 28 days. At the end of the experimental period, antioxidant enzyme activities (SOD, CAT, GST, and GPx) and MDA levels were evaluated in small intestinal tissues obtained from rats. At the end of the 28-day treatment period, it was determined that MDA level increased and antioxidant enzyme activities decreased in the intestinal tissue of rats treated with imidacloprid. However, when imidacloprid plus resveratrol plus berberberine treated group, imidacloprid plus resveratrol treated group and imidacloprid plus berberine treated group were compared with imidocloprid group, a significant decrease in MDA level and a significant increase in antioxidant enzyme activities were observed. Histological findings support the protective properties of resveratrol and berberine. The results of this study showed that berberine and resveratrol, which were administered to prevent damage caused by imidacloprid in the small intestine tissue of rats, showed a positive effect and improved the studied parameters.

Anahtar Kelimeler

Imidacloprid, Berberine, Resveratrol, Small Intestine, Oxidative Stress

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Hayvan Fizyolojisi - Hücre

Bölüm

Araştırma Makalesi

Yazarlar

Mohammed Adnan Jado
0000-0003-4155-8345
Türkiye

Yusuf Kalender ^*
0000-0001-5457-0517
Türkiye

Yayımlanma Tarihi

29 Kasım 2024

Gönderilme Tarihi

10 Haziran 2024

Kabul Tarihi

25 Temmuz 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 2 Sayı: 2

DOI

https://doi.org/10.70500/bjs.1498720

IZ

https://izlik.org/JA59ZE97AD

APA

Jado, M. A., & Kalender, Y. (2024). Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol. Bozok Journal of Science, 2(2), 38-46. https://doi.org/10.70500/bjs.1498720

AMA

1.Jado MA, Kalender Y. Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol. BJS. 2024;2(2):38-46. doi:10.70500/bjs.1498720

Chicago

Jado, Mohammed Adnan, ve Yusuf Kalender. 2024. “Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol”. Bozok Journal of Science 2 (2): 38-46. https://doi.org/10.70500/bjs.1498720.

EndNote

Jado MA, Kalender Y (01 Kasım 2024) Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol. Bozok Journal of Science 2 2 38–46.

IEEE

[1]M. A. Jado ve Y. Kalender, “Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol”, BJS, c. 2, sy 2, ss. 38–46, Kas. 2024, doi: 10.70500/bjs.1498720.

ISNAD

Jado, Mohammed Adnan - Kalender, Yusuf. “Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol”. Bozok Journal of Science 2/2 (01 Kasım 2024): 38-46. https://doi.org/10.70500/bjs.1498720.

JAMA

1.Jado MA, Kalender Y. Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol. BJS. 2024;2:38–46.

MLA

Jado, Mohammed Adnan, ve Yusuf Kalender. “Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol”. Bozok Journal of Science, c. 2, sy 2, Kasım 2024, ss. 38-46, doi:10.70500/bjs.1498720.

Vancouver

1.Mohammed Adnan Jado, Yusuf Kalender. Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol. BJS. 01 Kasım 2024;2(2):38-46. doi:10.70500/bjs.1498720

Cited By

Recovery Effects of Resveratrol and Berberine Against Inflammation, Oxidative Stress, Biochemical, and Pathological Damage in Rats with Imidacloprid-Induced Hepatorenal Toxicity

Bratislava Medical Journal

https://doi.org/10.1007/s44411-026-00581-7

İmidakloprid’in Sıçan Kan ve Dalak Dokularında Neden Olduğu Oksidatif Strese Karşı Resveratrol ve Berberin’in Koruyucu Etkileri

Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi

https://doi.org/10.47495/okufbed.1738508

Öz

Small Intestinal Toxicity Induced by Imidacloprid in Rats and The Protective Role of Berberine and Resveratrol

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Recovery Effects of Resveratrol and Berberine Against Inflammation, Oxidative Stress, Biochemical, and Pathological Damage in Rats with Imidacloprid-Induced Hepatorenal Toxicity

İmidakloprid’in Sıçan Kan ve Dalak Dokularında Neden Olduğu Oksidatif Strese Karşı Resveratrol ve Berberin’in Koruyucu Etkileri