Preparation of Hydrogels of Methacrylamide with Mono and Dicarboxylic Acids: Investigation of Their Swelling Behavior
Öz
Methacrylamide (MAAm) hydrogels were synthesized with mono- (crotonic acid, CrA) and dicarboxylic (maleic acid, MAA) acids via radical copolymerization, utilizing potassium persulfate (KPS) as the initiator and methylenebisacrylamide (MBAAm) as the crosslinker. The swelling behavior of the resulting hydrogels was systematically investigated, with particular focus on the effects of monomer ratio, initiator and crosslinker concentrations, as well as polymerization temperature. These parameters were optimized to maximize the swelling ratio. For poly(MAAm/CrA) hydrogels, the formulation containing 85/15 MAAm/CrA (mol/mol), 2 mol% KPS, 1 mol% MBAAm, and synthesized at 55 °C exhibited the highest swelling capacity (480%) in distilled water. In contrast, for poly(MAAm/MAA) hydrogels, the composition of 75/25 MAAm/MAA (mol/mol) with 1 mol% KPS, 1 mol% MBAAm, and polymerized at 55 °C showed a maximum swelling of 1100%. Further investigations explored the influence of pH, temperature, and electrolyte concentration and type on the swelling properties of the hydrogels prepared under optimized conditions. Both hydrogels demonstrated peak swelling behavior at pH 7, with their swelling profiles varying in response to changes in temperature, electrolyte concentration, and electrolyte type. Swelling kinetics studies revealed that the MAAm/CrA hydrogel exhibited Fickian diffusion in distilled water at room temperature, while the MAAm/MAA hydrogel followed a non-Fickian diffusion mechanism. Scanning electron microscopy (SEM) analysis indicated that the hydrogels synthesized under optimal conditions possessed a porous and well-organized network structure.
Anahtar Kelimeler
poly(methacrylamide-co-crotonic acid), poly(methacrylamide-co-maleic acid), hydrogels, swelling
Etik Beyan
The authors declare no competing interests.
Teşekkür
The authors gratefully thank the infrastructure provided by Yozgat Bozok University.
Kaynakça
- M. Flemming, N.A. Peppas, “Complexation graft copolymer networks: Swelling properties, calcium binding and proteolytic enzyme inhibition,” Biomaterials, vol. 20, 1701–1708, 1999.
- F. Ganji, S. Vasheghani-Farahani, E. Vasheghani-Farahani, “Theoretical Description of Hydrogel Swelling: A Review” Iranian Pol. J., vol. 19, 375–398, 2010.
- X. Li, M. Li, L. Tang, D. Shi, E. Lam, J. Bae, “3D shape morphing of stimuli-responsive composite hydrogels” Mater. Chem. Fron.,vol. 7, 5989–6034, 2023.
- R. Coşkun, A. Delibaş, “Removal of methylene blue from aqueous solutions by poly (2-acrylamido-2- methylpropane sulfonic acid-co-itaconic acid) hydrogels” Polymer Bulletin, 68(7),1889-1903, 2012.
- N. A. Peppas, A. G. Mikos, “Hydrogels in medicine and pharmacy; Peppas N. A.,ed., Preparation methods and structure of hydrogels,” vol. 1, 1-25, 1986.
- N. H. Thang, T. B. Chien, D. X. Cuong, “Polymer-Based Hydrogels Applied in Drug Delivery: An Overview” Gels, vol. 9, 523-560, 2023.
- P. Yadav, S. Singh, S. Jaiswal, R. Kumar ‘Synthetic and natural polymer hydrogels: A review of 3D spheroids and drug delivery’’., International Journal of Biological Macromolecules, Vol 280(4), 136126, 2024.
- N.A. Peppas, G.A. Mikos, "Preparation methods and structure of hydrogels", Hydrogels Med. and Pharm., vol. 1,1 -25, 1986.
- D. Saraydın, ‘’Akrilamid-Maleik Asit Hidrojellerinin Hazırlanmasi, Karakterizasyonu ve Bazı Su Kirleticilerinin Tutulmasında Kullanımı’’, Doktora Tezi., Cumhuriyet Üniversitesi., 1992.
- Y. Yu, R. Feng, S. Yu, J. Li, Y. Wang, Y. Song, X. Yang, W. Pan, S. Li, ‘Nanostructured lipid carrier-based pH and temperature dual-responsive hydrogel composed of carboxymethyl chitosan and poloxamer for drug delivery’’, Int. J. Biol. Macromol., 114, pp. 462-469, 2018.