Cardiotoxic Effect of Fenamiphos and Protective Role of Naringenin in Rats

Yıl 2023, Cilt: 1 Sayı: 2, 73 - 80, 30.11.2023

Gökçe Ceren Boya Fatma Gökçe Apaydın

Öz

Fenamiphos is a broad-spectrum organophosphate insecticide. It is used in agriculture to control soil nematodes in several cops like peanuts, tomatoes, ginger, as well as in pineapples, cotton in worldwide. Naringenin is one of the flavonoids and was found to display strong anti-inflammatory and antioxidant effect. In this study, we investigated how naringenin had protective effects on the damaged rat heart tissue caused by fenamiphos. In the study, experimental rats were organized into four equal groups. These; control, naringenin, fenamiphos and fenamiphos plus naringenin. The chemicals were given to the rats by orally during for 28 days. After 4th week, malondialdehyde (MDA) levels and antioxidant enzyme activities (SOD, CAT, GPx and GST) in rat heart tissues were investigated spectrophotometrically by various methods. Also, histopathological changes were analysed by light microscope. Any important changes were observed between control and naringenin treated groups. End of the experimental timeline, fenamiphos caused increasing the levels of MDA while a decrease in antioxidant enzyme activities were detected in comparison with the control animals. In addition, many pathological changes were observed in fenamiphos treated group. Fewer pathological changes and less oxidative damage were detected in the group in which fenamiphos and naringenin were administered together. In the study it is observed that fenamiphos caused oxidative stress and histopathological changes in rat heart tissue, naringenin treatment reduced this toxicity.

Anahtar Kelimeler

Fenamiphos, Naringenin, Heart, Oxidative stress, Histopathology

Kaynakça

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